The effect of triclosan coated sutures on rate of surgical site infection after hip and knee replacement: a protocol for a double-blind randomised controlled trial.

BACKGROUND: 187,000 hip and knee joint replacements are performed every year in the National Health Service (NHS). One of the commonest complications is surgical site infection (SSI), and this represents a significant burden in terms of patient morbidity, mortality and cost to health services around the world. The aim of this randomised controlled trial (RCT) is to determine if the addition of triclosan coated sutures to a standard regimen can reduce the rate of SSI after total knee replacement (TKR) and total hip replacement (THR). METHODS: 2400 patients due to undergo a total hip or knee replacement are being recruited into this two-centre RCT. Participants are recruited before surgery and randomised to either standard care or intervention group. Participants, outcome assessors and statistician are blind to treatment allocation throughout the study. The intervention consists of triclosan coated sutures vs. standard non-coated sutures. The primary outcome is the Health protection Agency (HPA) defined superficial surgical site infection at 30 days. Secondary outcomes include HPA defined deep surgical site infection at 12 months, length of hospital stay, critical care stay, and payer costs. DISCUSSION: To date there are no orthopaedic randomised controlled trials on this scale assessing the effectiveness of a surgical intervention, particularly those that can be translated across the surgical specialities. The results from this trial will inform evidence-based recommendations for suture selection in the management of patients undergoing total hip or knee replacement. If triclosan coated sutures are found to be an effective intervention, implementation into clinical practice could improve long-term outcomes for patients undergoing hip and knee replacement. TRIAL REGISTRATION: Current Controlled Trials ISRCTN 17807356.

Upper arm length model suggests transient bilateral asymmetry is associated with right thoracic adolescent idiopathic scoliosis (RT-AIS) with implications for pathogenesis and estimation of linear skeletal overgrowth.

INTRODUCTION: In girls with adolescent idiopathic scoliosis (AIS) the finding of abnormal extra-spinal bilateral skeletal length asymmetries in upper limbs, periapical ribs, and ilia begs the question whether these bilateral asymmetries are connected in some way with pathogenesis. MATERIAL AND METHODS: We investigated upper arm length (UAL) asymmetries in two groups of right-handed girls aged 11-18 years with right thoracic adolescent idiopathic scoliosis (RT-AIS, n=95) from preoperative and screening referrals (mean Cobb angle 46°) and healthy controls (n=240). Right and left UAL were measured with a Harpenden anthropometer of the Holtain equipment, Asymmetry was calculated as UAL difference, right minus left, in mm. Repeatability of the measurements was assessed as technical error of the measurement and coefficient of reliability. RESULTS: In girls with RT-AIS, UAL asymmetry was greater than in healthy girls, regressed negatively with age and correlated significantly with Cobb angle and apical vertebral rotation. In healthy girls, UAL asymmetry was unrelated to age. Plotted against years after estimated menarcheal age, UAL asymmetry decreased significantly for girls with RT-AIS but not for healthy girls. DISCUSSION AND CONCLUSIONS: The apparent transience of the abnormal UAL asymmetry suggests it is not secondary to spinal deformity but pathogenetically associated with it. We suggest two hypotheses to account for these changes: (1) a transient asymmetry process with growth velocity; and (2) in the light of subsequent research, early skeletal overgrowth with catch-down growth affecting right but not left upper arm. The relation of the upper arm length asymmetry to the increased length of periapical left ribs reported for RT-AIS is unknown. Right upper arm length may provide a more simple model than arm span, for estimating linear skeletal overgrowth of girls with RT-AIS.

The reliability of the Shuttle Walking Test, the Swiss Spinal Stenosis Questionnaire, the Oxford Spinal Stenosis Score, and the Oswestry Disability Index in the assessment of patients with lumbar spinal stenosis.

STUDY DESIGN: The Shuttle Walking Test (SWT), the Swiss Spinal Stenosis (SSS) Questionnaire, the Oxford Claudication Score (OCS), and the Oswestry Disability Index (ODI) were administered to patients with lumbar spinal stenosis and neurogenic claudication. OBJECTIVE: To determine reliability of the SWT, the SSS (Q1-12), the OCS, and the ODI in lumbar spinal stenosis assessment. SUMMARY OF BACKGROUND DATA: Reliability data for exercise tests in lumbar spinal stenosis are lacking. METHODS: To determine reliability, 32 clinic patients with lumbar spinal stenosis were assessed twice, with 1 week between assessments. Retrospective data from 17 patients assessed before surgery and 18 months after surgery for lumbar spinal stenosis were used to investigate the use of reliability in a clinical setting. RESULTS: Test-retest reliability in terms of the intraclass correlation coefficient (ICC) was 0.92 for the SWT, 0.92 for the SSS, 0.83 for the OCS and 0.89 for the ODI. The mean percentage scores were 51 for the SSS, 45 for the OCS, and 40 for the ODI. To achieve 95% certainty of change between assessments for a single patient, the SSS would need to change by 15, the OCS by 20, and the ODI by 16. The mean SWT was 150 m, with a change of 76 m required for 95% confidence. Cronbach's alpha was 0.91 for the SSS, 0.90 for the OCS, and 0.89 for the ODI. The change in ODI correlated most strongly with patient satisfaction after surgery (rho = 0.80; P < 0.001). CONCLUSIONS: Fluctuations in a patient's symptoms result in wide individual confidence intervals. Performance on the SSS, OCS, and ODI questionnaires are broadly similar, the most precise being the condition-specific SSS. The SWT gives a snapshot of physical function, which is acceptable for group analysis. Use of the SWT for individual assessment after surgery is feasible.

Patient and parental perception of adolescent idiopathic scoliosis before and after surgery in comparison with surface and radiographic measurements.

STUDY DESIGN: This prospective 2-year follow-up study evaluated patients treated surgically for adolescent idiopathic scoliosis (AIS). OBJECTIVE: To report parents' perception, patients' perception, and pain and disability before and after surgery and to examine their relationship to anthropometric, back surface, and radiographic measurements. SUMMARY OF BACKGROUND DATA: No longitudinal studies have examined these factors and their interrelationships. METHODS: Between 1995 and 1999, 39 AIS patients treated by anterior or posterior USS (Universal Spine System, Stratec, Oberdorf, Switzerland) instrumentation had complete prospective questionnaire, back surface, and radiographic appraisal. RESULTS: The preoperative Visual Analogue Score (VAS) for pain-predominantly mild backache-was 24 mm (range, 0-78 mm), and the Oswestry Disability Index (ODI) score was 9.2% (0-44.4%). Patients and parents wanted surgery to correct spinal curvature, stop curve progression, and correct the rib-hump (thoracic) and hip and waist asymmetry (thoracolumbar curves). The maximum angle of trunk inclination correlated with VAS and with short-form McGill Pain Questionnaire scores for thoracic curves (P = 0.005, Spearman rank correlation coefficient). Apical vertebral translation correlated with short-form McGill scores and ODI for thoracolumbar curves (P < 0.006, Spearman rank correlation coefficient). Parents rated scoliosis problems more severely than did their children (P < 0.0001, repeated measures of multivariate analysis of variants). There was no change in body image, VAS, ODI, or short-form McGill scores by 2 years' follow-up. Parents and patients perceived scoliosis problems to be less by 2 years' follow-up (P < 0.0005, Wilcoxon matched-pairs signed ranks test). The preoperative surface asymmetry score correlated with the patients' grading of their rib-hump (P = 0.007). CONCLUSIONS: Back pain incidence was higher than reported for healthy adolescents. Oswestry Disability Index was within normal adult limits. Pain varied by curve type, related to the maximum angle of trunk inclination and the maximum apical vertebral translation. After surgery, back pain and ODI were unchanged, but concerns regarding scoliosis were reduced.