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1.

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

Yankova, Eliza; Blackaby, Wesley; Albertella, Mark; Rak, Justyna; De Braekeleer, Etienne; Tsagkogeorga, Georgia; Pilka, Ewa S; Aspris, Demetrios; Leggate, Dan; Hendrick, Alan G; Webster, Natalie A; Andrews, Byron; Fosbeary, Richard; Guest, Patrick; Irigoyen, Nerea; Eleftheriou, Maria; Gozdecka, Malgorzata; Dias, Joao M L; Bannister, Andrew J; Vick, Binje; Jeremias, Irmela; Vassiliou, George S; Rausch, Oliver; Tzelepis, Konstantinos; Kouzarides, Tony.

Nature ; 593(7860): 597-601, 2021 05.

Artículo en Inglés | MEDLINE | ID: mdl-33902106

2.

Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning.

Körtel, Nadine; Rücklé, Cornelia; Zhou, You; Busch, Anke; Hoch-Kraft, Peter; Sutandy, F X Reymond; Haase, Jacob; Pradhan, Mihika; Musheev, Michael; Ostareck, Dirk; Ostareck-Lederer, Antje; Dieterich, Christoph; Hüttelmaier, Stefan; Niehrs, Christof; Rausch, Oliver; Dominissini, Dan; König, Julian; Zarnack, Kathi.

Nucleic Acids Res ; 49(16): e92, 2021 09 20.

Artículo en Inglés | MEDLINE | ID: mdl-34157120

3.

A selective inhibitor reveals PI3KÎ³ dependence of T(H)17 cell differentiation.

Bergamini, Giovanna; Bell, Kathryn; Shimamura, Satoko; Werner, Thilo; Cansfield, Andrew; Müller, Katrin; Perrin, Jessica; Rau, Christina; Ellard, Katie; Hopf, Carsten; Doce, Carola; Leggate, Daniel; Mangano, Raffaella; Mathieson, Toby; O'Mahony, Alison; Plavec, Ivan; Rharbaoui, Faiza; Reinhard, Friedrich; Savitski, Mikhail M; Ramsden, Nigel; Hirsch, Emilio; Drewes, Gerard; Rausch, Oliver; Bantscheff, Marcus; Neubauer, Gitte.

Nat Chem Biol ; 8(6): 576-82, 2012 Apr 29.

Artículo en Inglés | MEDLINE | ID: mdl-22544264

4.

RNA stability controlled by m⁶A methylation contributes to X-to-autosome dosage compensation in mammals.

Rücklé, Cornelia; Körtel, Nadine; Basilicata, M Felicia; Busch, Anke; Zhou, You; Hoch-Kraft, Peter; Tretow, Kerstin; Kielisch, Fridolin; Bertin, Marco; Pradhan, Mihika; Musheev, Michael; Schweiger, Susann; Niehrs, Christof; Rausch, Oliver; Zarnack, Kathi; Keller Valsecchi, Claudia Isabelle; König, Julian.

Nat Struct Mol Biol ; 30(8): 1207-1215, 2023 08.

Artículo en Inglés | MEDLINE | ID: mdl-37202476

5.

Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.

Guirguis, Andrew A; Ofir-Rosenfeld, Yaara; Knezevic, Kathy; Blackaby, Wesley; Hardick, David; Chan, Yih-Chih; Motazedian, Ali; Gillespie, Andrea; Vassiliadis, Dane; Lam, Enid Y N; Tran, Kevin; Andrews, Byron; Harbour, Michael E; Vasiliauskaite, Lina; Saunders, Claire J; Tsagkogeorga, Georgia; Azevedo, Aleksandra; Obacz, Joanna; Pilka, Ewa S; Carkill, Marie; MacPherson, Laura; Wainwright, Elanor N; Liddicoat, Brian; Blyth, Benjamin J; Albertella, Mark R; Rausch, Oliver; Dawson, Mark A.

Cancer Discov ; 13(10): 2228-2247, 2023 10 05.

Artículo en Inglés | MEDLINE | ID: mdl-37548590

6.

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.

Chessa, Tamara A M; Anderson, Karen E; Hu, Yanhua; Xu, Qingbo; Rausch, Oliver; Stephens, Len R; Hawkins, Phillip T.

Blood ; 116(26): 6027-36, 2010 Dec 23.

Artículo en Inglés | MEDLINE | ID: mdl-20861461

7.

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.

Anderson, Karen E; Chessa, Tamara A M; Davidson, Keith; Henderson, Robert B; Walker, Simon; Tolmachova, Tanya; Grys, Katarzyna; Rausch, Oliver; Seabra, Miguel C; Tybulewicz, Victor L J; Stephens, Len R; Hawkins, Phillip T.

Blood ; 116(23): 4978-89, 2010 Dec 02.

Artículo en Inglés | MEDLINE | ID: mdl-20813901

8.

Predicting genes associated with RNA methylation pathways using machine learning.

Tsagkogeorga, Georgia; Santos-Rosa, Helena; Alendar, Andrej; Leggate, Dan; Rausch, Oliver; Kouzarides, Tony; Weisser, Hendrik; Han, Namshik.

Commun Biol ; 5(1): 868, 2022 08 25.

Artículo en Inglés | MEDLINE | ID: mdl-36008532

9.

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.

Anderson, Karen E; Boyle, Keith B; Davidson, Keith; Chessa, Tamara A M; Kulkarni, Suhasini; Jarvis, Gavin E; Sindrilaru, Anca; Scharffetter-Kochanek, Karin; Rausch, Oliver; Stephens, Len R; Hawkins, Phillip T.

Blood ; 112(13): 5202-11, 2008 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-18755982

10.

RNA-modifying enzymes and their function in a chromatin context.

Tzelepis, Konstantinos; Rausch, Oliver; Kouzarides, Tony.

Nat Struct Mol Biol ; 26(10): 858-862, 2019 10.

Artículo en Inglés | MEDLINE | ID: mdl-31582848

11.

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

Buckley, George M; Ceska, Thomas A; Fraser, Joanne L; Gowers, Lewis; Groom, Colin R; Higueruelo, Alicia Perez; Jenkins, Kerry; Mack, Stephen R; Morgan, Trevor; Parry, David M; Pitt, William R; Rausch, Oliver; Richard, Marianna D; Sabin, Verity.

Bioorg Med Chem Lett ; 18(11): 3291-5, 2008 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-18482836

12.

IRAK-4 inhibitors. Part 1: a series of amides.

Buckley, George M; Gowers, Lewis; Higueruelo, Alicia Perez; Jenkins, Kerry; Mack, Stephen R; Morgan, Trevor; Parry, David M; Pitt, William R; Rausch, Oliver; Richard, Marianna D; Sabin, Verity; Fraser, Joanne L.

Bioorg Med Chem Lett ; 18(11): 3211-4, 2008 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-18474425

13.

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

Buckley, George M; Fosbeary, Richard; Fraser, Joanne L; Gowers, Lewis; Higueruelo, Alicia P; James, Lynwen A; Jenkins, Kerry; Mack, Stephen R; Morgan, Trevor; Parry, David M; Pitt, William R; Rausch, Oliver; Richard, Marianna D; Sabin, Verity.

Bioorg Med Chem Lett ; 18(12): 3656-60, 2008 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-18501603

14.

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages.

Sturgess, Katherine; Yankova, Eliza; Vijayabaskar, M S; Isobe, Tomoya; Rak, Justyna; Kucinski, Iwo; Barile, Melania; Webster, Natalie A; Eleftheriou, Maria; Hannah, Rebecca; Gozdecka, Malgorzata; Vassiliou, George; Rausch, Oliver; Wilson, Nicola K; Göttgens, Berthold; Tzelepis, Konstantinos.

Leukemia ; 37(10): 2133-2137, 2023 10.

Artículo en Inglés | MEDLINE | ID: mdl-37464070

15.

Author Correction: RNA stability controlled by m⁶A methylation contributes to X-to-autosome dosage compensation in mammals.

Rücklé, Cornelia; Körtel, Nadine; Basilicata, M Felicia; Busch, Anke; Zhou, You; Hoch-Kraft, Peter; Tretow, Kerstin; Kielisch, Fridolin; Bertin, Marco; Pradhan, Mihika; Musheev, Michael; Schweiger, Susann; Niehrs, Christof; Rausch, Oliver; Zarnack, Kathi; Keller Valsecchi, Claudia Isabelle; König, Julian.

Nat Struct Mol Biol ; 30(10): 1607, 2023 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-37415011

16.

High content cellular screening.

Rausch, Oliver.

Curr Opin Chem Biol ; 10(4): 316-20, 2006 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-16793326

17.

CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.

Cansfield, Andrew D; Ladduwahetty, Tammy; Sunose, Mihiro; Ellard, Katie; Lynch, Rosemary; Newton, Anthea L; Lewis, Ann; Bennett, Gavin; Zinn, Nico; Thomson, Douglas W; Rüger, Anne J; Feutrill, John T; Rausch, Oliver; Watt, Alan P; Bergamini, Giovanna.

ACS Med Chem Lett ; 7(8): 768-73, 2016 Aug 11.

Artículo en Inglés | MEDLINE | ID: mdl-27563401

18.

Localizing the lipid products of PI3KÎ³ in neutrophils.

Norton, Laura; Lindsay, Yvonne; Deladeriere, Arnaud; Chessa, Tamara; Guillou, Hervé; Suire, Sabine; Lucocq, John; Walker, Simon; Andrews, Simon; Segonds-Pichon, Anne; Rausch, Oliver; Finan, Peter; Sasaki, Takehiko; Du, Cheng-Jin; Bretschneider, Till; Ferguson, G John; Hawkins, Phillip T; Stephens, Len.

Adv Biol Regul ; 60: 36-45, 2016 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-26596865

19.

Use of high-content analysis for compound screening and target selection.

Rausch, Oliver.

IDrugs ; 8(7): 573-7, 2005 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-15973566

20.

High-Content Analysis 2005--CHI's Second Annual Conference. 25-28 January 2005, San Francisco, CA, USA.

Rausch, Oliver.

IDrugs ; 8(3): 197-9, 2005 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-15772886

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Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia.

Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning.

A selective inhibitor reveals PI3KÎ³ dependence of T(H)17 cell differentiation.

RNA stability controlled by m⁶A methylation contributes to X-to-autosome dosage compensation in mammals.

Inhibition of METTL3 Results in a Cell-Intrinsic Interferon Response That Enhances Antitumor Immunity.

Phosphorylation of threonine 154 in p40phox is an important physiological signal for activation of the neutrophil NADPH oxidase.

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils.

Predicting genes associated with RNA methylation pathways using machine learning.

CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks.

RNA-modifying enzymes and their function in a chromatin context.

IRAK-4 inhibitors. Part II: a structure-based assessment of imidazo[1,2-a]pyridine binding.

IRAK-4 inhibitors. Part 1: a series of amides.

IRAK-4 inhibitors. Part III: a series of imidazo[1,2-a]pyridines.

Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages.

Author Correction: RNA stability controlled by m⁶A methylation contributes to X-to-autosome dosage compensation in mammals.

High content cellular screening.

CZ415, a Highly Selective mTOR Inhibitor Showing in Vivo Efficacy in a Collagen Induced Arthritis Model.

Localizing the lipid products of PI3KÎ³ in neutrophils.

Use of high-content analysis for compound screening and target selection.

High-Content Analysis 2005--CHI's Second Annual Conference. 25-28 January 2005, San Francisco, CA, USA.