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1.

APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.

Haney, Michael S; Pálovics, Róbert; Munson, Christy Nicole; Long, Chris; Johansson, Patrik K; Yip, Oscar; Dong, Wentao; Rawat, Eshaan; West, Elizabeth; Schlachetzki, Johannes C M; Tsai, Andy; Guldner, Ian Hunter; Lamichhane, Bhawika S; Smith, Amanda; Schaum, Nicholas; Calcuttawala, Kruti; Shin, Andrew; Wang, Yung-Hua; Wang, Chengzhong; Koutsodendris, Nicole; Serrano, Geidy E; Beach, Thomas G; Reiman, Eric M; Glass, Christopher K; Abu-Remaileh, Monther; Enejder, Annika; Huang, Yadong; Wyss-Coray, Tony.

Nature ; 628(8006): 154-161, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38480892

2.

APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.

Montagne, Axel; Nation, Daniel A; Sagare, Abhay P; Barisano, Giuseppe; Sweeney, Melanie D; Chakhoyan, Ararat; Pachicano, Maricarmen; Joe, Elizabeth; Nelson, Amy R; D'Orazio, Lina M; Buennagel, David P; Harrington, Michael G; Benzinger, Tammie L S; Fagan, Anne M; Ringman, John M; Schneider, Lon S; Morris, John C; Reiman, Eric M; Caselli, Richard J; Chui, Helena C; Tcw, Julia; Chen, Yining; Pa, Judy; Conti, Peter S; Law, Meng; Toga, Arthur W; Zlokovic, Berislav V.

Nature ; 581(7806): 71-76, 2020 05.

Artículo en Inglés | MEDLINE | ID: mdl-32376954

3.

Brain morphometry in former American football players: Findings from the DIAGNOSE CTE research project.

Arciniega, Hector; Baucom, Zachary H; Tuz-Zahra, Fatima; Tripodis, Yorghos; John, Omar; Carrington, Holly; Kim, Nicholas; Knyazhanskaya, Evdokiya E; Jung, Leonard B; Breedlove, Katherine; Wiegand, Tim L T; Daneshvar, Daniel H; Rushmore, R Jarrett; Billah, Tashrif; Pasternak, Ofer; Coleman, Michael J; Adler, Charles H; Bernick, Charles; Balcer, Laura J; Alosco, Michael L; Koerte, Inga K; Lin, Alexander P; Cummings, Jeffrey L; Reiman, Eric M; Stern, Robert A; Shenton, Martha E; Bouix, Sylvain.

Brain ; 2024 Mar 27.

Artículo en Inglés | MEDLINE | ID: mdl-38533783

4.

Genetic control of the human brain proteome.

Robins, Chloe; Liu, Yue; Fan, Wen; Duong, Duc M; Meigs, Jacob; Harerimana, Nadia V; Gerasimov, Ekaterina S; Dammer, Eric B; Cutler, David J; Beach, Thomas G; Reiman, Eric M; De Jager, Philip L; Bennett, David A; Lah, James J; Wingo, Aliza P; Levey, Allan I; Seyfried, Nicholas T; Wingo, Thomas S.

Am J Hum Genet ; 108(3): 400-410, 2021 03 04.

Artículo en Inglés | MEDLINE | ID: mdl-33571421

5.

Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project.

van Amerongen, Suzan; Pulukuri, Surya V; Tuz-Zahra, Fatima; Tripodis, Yorghos; Cherry, Jonathan D; Bernick, Charles; Geda, Yonas E; Wethe, Jennifer V; Katz, Douglas I; Alosco, Michael L; Adler, Charles H; Balcer, Laura J; Ashton, Nicholas J; Blennow, Kaj; Zetterberg, Henrik; Daneshvar, Daniel H; Colasurdo, Elizabeth A; Iliff, Jeffrey J; Li, Gail; Peskind, Elaine R; Shenton, Martha E; Reiman, Eric M; Cummings, Jeffrey L; Stern, Robert A.

J Neuroinflammation ; 21(1): 46, 2024 Feb 09.

Artículo en Inglés | MEDLINE | ID: mdl-38336728

6.

Drug trial for Alzheimer's disease is a game changer.

Reiman, Eric M.

Nature ; 615(7950): 42-43, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36781970

7.

Harmonizing florbetapir and PiB PET measurements of cortical Aß plaque burden using multiple regions-of-interest and machine learning techniques: An alternative to the Centiloid approach.

Chen, Kewei; Ghisays, Valentina; Luo, Ji; Chen, Yinghua; Lee, Wendy; Wu, Teresa; Reiman, Eric M; Su, Yi.

Alzheimers Dement ; 20(3): 2165-2172, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38276892

8.

Effects of the active amyloid beta immunotherapy CAD106 on PET measurements of amyloid plaque deposition in cognitively unimpaired APOE Îµ4 homozygotes.

Riviere, Marie-Emmanuelle; Langbaum, Jessica B; Turner, R Scott; Rinne, Juha O; Sui, Yihan; Cazorla, Pilar; Ricart, Javier; Meneses, Kathleen; Caputo, Angelika; Tariot, Pierre N; Reiman, Eric M; Graf, Ana.

Alzheimers Dement ; 20(3): 1839-1850, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38145469

9.

Flortaucipir tau PET findings from former professional and college American football players in the DIAGNOSE CTE research project.

Su, Yi; Protas, Hillary; Luo, Ji; Chen, Kewei; Alosco, Michael L; Adler, Charles H; Balcer, Laura J; Bernick, Charles; Au, Rhoda; Banks, Sarah J; Barr, William B; Coleman, Michael J; Dodick, David W; Katz, Douglas I; Marek, Kenneth L; McClean, Michael D; McKee, Ann C; Mez, Jesse; Daneshvar, Daniel H; Palmisano, Joseph N; Peskind, Elaine R; Turner, Robert W; Wethe, Jennifer V; Rabinovici, Gil; Johnson, Keith; Tripodis, Yorghos; Cummings, Jeffrey L; Shenton, Martha E; Stern, Robert A; Reiman, Eric M.

Alzheimers Dement ; 20(3): 1827-1838, 2024 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-38134231

10.

Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players.

Alosco, Michael L; Su, Yi; Stein, Thor D; Protas, Hillary; Cherry, Jonathan D; Adler, Charles H; Balcer, Laura J; Bernick, Charles; Pulukuri, Surya Vamsi; Abdolmohammadi, Bobak; Coleman, Michael J; Palmisano, Joseph N; Tripodis, Yorghos; Mez, Jesse; Rabinovici, Gil D; Marek, Kenneth L; Beach, Thomas G; Johnson, Keith A; Huber, Bertrand Russell; Koerte, Inga; Lin, Alexander P; Bouix, Sylvain; Cummings, Jeffrey L; Shenton, Martha E; Reiman, Eric M; McKee, Ann C; Stern, Robert A.

Eur J Nucl Med Mol Imaging ; 50(2): 435-452, 2023 01.

Artículo en Inglés | MEDLINE | ID: mdl-36152064

11.

Volume atrophy in medial temporal cortex and verbal memory scores in American Indians: Data from the Strong Heart Study.

Suchy-Dicey, Astrid; Su, Yi; Buchwald, Dedra S; Manson, Spero M; Reiman, Eric M.

Alzheimers Dement ; 19(6): 2298-2306, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-36453775

12.

Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease.

Aguillon, David; Langella, Stephanie; Chen, Yinghua; Sanchez, Justin S; Su, Yi; Vila-Castelar, Clara; Vasquez, Daniel; Zetterberg, Henrik; Hansson, Oskar; Dage, Jeffrey L; Janelidze, Shorena; Chen, Kewei; Fox-Fuller, Joshua T; Aduen, Paula; Martinez, Jairo E; Garcia, Gloria; Baena, Ana; Guzman, Claudia; Johnson, Keith A; Sperling, Reisa A; Blennow, Kaj; Reiman, Eric M; Lopera, Francisco; Quiroz, Yakeel T.

Alzheimers Dement ; 19(6): 2585-2594, 2023 06.

Artículo en Inglés | MEDLINE | ID: mdl-36571821

13.

A public resource of baseline data from the Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial.

Reiman, Eric M; Pruzin, Jeremy J; Rios-Romenets, Silvia; Brown, Chris; Giraldo, Margarita; Acosta-Baena, Natalia; Tobon, Carlos; Hu, Nan; Chen, Yinghua; Ghisays, Valentina; Enos, Jessica; Goradia, Dhruman D; Lee, Wendy; Luo, Ji; Malek-Ahmadi, Michael; Protas, Hillary; Thomas, Ronald G; Chen, Kewei; Su, Yi; Boker, Connie; Mastroeni, Diego; Alvarez, Sergio; Quiroz, Yakeel T; Langbaum, Jessica B; Sink, Kaycee M; Lopera, Francisco; Tariot, Pierre N.

Alzheimers Dement ; 19(5): 1938-1946, 2023 05.

Artículo en Inglés | MEDLINE | ID: mdl-36373344

14.

Recommendations to address key recruitment challenges of Alzheimer's disease clinical trials.

Langbaum, Jessica B; Zissimopoulos, Julie; Au, Rhoda; Bose, Niranjan; Edgar, Chris J; Ehrenberg, Evan; Fillit, Howard; Hill, Carl V; Hughes, Lynne; Irizarry, Michael; Kremen, Sarah; Lakdawalla, Darius; Lynn, Nancy; Malzbender, Kristina; Maruyama, Tetsuyuki; Massett, Holly A; Patel, Deep; Peneva, Desi; Reiman, Eric M; Romero, Klaus; Routledge, Carol; Weiner, Michael W; Weninger, Stacie; Aisen, Paul S.

Alzheimers Dement ; 19(2): 696-707, 2023 02.

Artículo en Inglés | MEDLINE | ID: mdl-35946590

15.

Sex differences in blood biomarkers and cognitive performance in individuals with autosomal dominant Alzheimer's disease.

Vila-Castelar, Clara; Chen, Yinghua; Langella, Stephanie; Lopera, Francisco; Zetterberg, Henrik; Hansson, Oskar; Dage, Jeffrey L; Janelidzde, Shorena; Su, Yi; Chen, Kewei; Pluim McDowell, Celina; Martinez, Jairo E; Ramirez-Gomez, Liliana; Garcia, Gloria; Aguillon, David; Baena, Ana; Giraldo-Chica, Margarita; Protas, Hillary D; Ghisays, Valentina; Rios-Romenets, Silvia; Tariot, Pierre N; Blennow, Kaj; Reiman, Eric M; Quiroz, Yakeel T.

Alzheimers Dement ; 19(9): 4127-4138, 2023 09.

Artículo en Inglés | MEDLINE | ID: mdl-37279390

16.

White matter hyperintensities in former American football players.

Alosco, Michael L; Tripodis, Yorghos; Baucom, Zachary H; Adler, Charles H; Balcer, Laura J; Bernick, Charles; Mariani, Megan L; Au, Rhoda; Banks, Sarah J; Barr, William B; Wethe, Jennifer V; Cantu, Robert C; Coleman, Michael J; Dodick, David W; McClean, Michael D; McKee, Ann C; Mez, Jesse; Palmisano, Joseph N; Martin, Brett; Hartlage, Kaitlin; Lin, Alexander P; Koerte, Inga K; Cummings, Jeffrey L; Reiman, Eric M; Stern, Robert A; Shenton, Martha E; Bouix, Sylvain.

Alzheimers Dement ; 19(4): 1260-1273, 2023 04.

Artículo en Inglés | MEDLINE | ID: mdl-35996231

17.

Tau Positron-Emission Tomography in Former National Football League Players.

Stern, Robert A; Adler, Charles H; Chen, Kewei; Navitsky, Michael; Luo, Ji; Dodick, David W; Alosco, Michael L; Tripodis, Yorghos; Goradia, Dhruman D; Martin, Brett; Mastroeni, Diego; Fritts, Nathan G; Jarnagin, Johnny; Devous, Michael D; Mintun, Mark A; Pontecorvo, Michael J; Shenton, Martha E; Reiman, Eric M.

N Engl J Med ; 380(18): 1716-1725, 2019 05 02.

Artículo en Inglés | MEDLINE | ID: mdl-30969506

18.

Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia.

Sepulveda-Falla, Diego; Sanchez, Justin S; Almeida, Maria Camila; Boassa, Daniela; Acosta-Uribe, Juliana; Vila-Castelar, Clara; Ramirez-Gomez, Liliana; Baena, Ana; Aguillon, David; Villalba-Moreno, Nelson David; Littau, Jessica Lisa; Villegas, Andres; Beach, Thomas G; White, Charles L; Ellisman, Mark; Krasemann, Susanne; Glatzel, Markus; Johnson, Keith A; Sperling, Reisa A; Reiman, Eric M; Arboleda-Velasquez, Joseph F; Kosik, Kenneth S; Lopera, Francisco; Quiroz, Yakeel T.

Acta Neuropathol ; 144(3): 589-601, 2022 09.

Artículo en Inglés | MEDLINE | ID: mdl-35838824

19.

Design and Development of a Community-Based, Interdisciplinary, Collaborative Dementia Care Program.

Goldfarb, Danielle; Allen, Angela M; Nisson, Lori E; Petitti, Diana B; Saner, Donald; Langford, Carrie; Burke, William J; Reiman, Eric M; Atri, Alireza; Tariot, Pierre N.

Am J Geriatr Psychiatry ; 30(6): 651-660, 2022 06.

Artículo en Inglés | MEDLINE | ID: mdl-34893448

20.

Limitations of clinical trial sample size estimate by subtraction of two measurements.

Chen, Kewei; Guo, Xiaojuan; Pan, Rong; Xiong, Chengjie; Harvey, Danielle J; Chen, Yinghua; Yao, Li; Su, Yi; Reiman, Eric M.

Stat Med ; 41(7): 1137-1147, 2022 03 30.

Artículo en Inglés | MEDLINE | ID: mdl-34725853

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