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1.
Pacing Clin Electrophysiol ; 41(5): 511-516, 2018 05.
Artículo en Inglés | MEDLINE | ID: mdl-29476654

RESUMEN

BACKGROUND: The subcutaneous implantable cardioverter-defibrillator (S-ICD) requires preimplant screening to ensure appropriate sensing and reduce risk of inappropriate shocks. Screening can be performed using either an ICD programmer or a 12-lead electrocardiogram (ECG) machine. It is unclear whether differences in signal filtering and digital sampling change the screening success rate. METHODS: Subjects were recruited if they had a transvenous single-lead ICD without pacing requirements or were candidates for a new ICD. Screening was performed using both a Boston Scientific ZOOM programmer (Marlborough, MA, USA) and General Electric MAC 5000 ECG machine (Fairfield, CT, USA). A pass was defined as having at least one lead that fit within the screening template in both supine and sitting positions. RESULTS: A total of 69 subjects were included and 27 sets of ECG leads had differing screening results between the two machines (7%). Of these sets, 22 (81%) passed using the ECG machine but failed using the programmer and five (19%) passed using the ECG machine but failed using the programmer (P < 0.001). Four subjects (6%) passed screening using the ECG machine but failed using the programmer. No subject passed screening with the programmer but failed with the ECG machine. CONCLUSION: There can be occasional disagreement in S-ICD patient screening between an ICD programmer and ECG machine, all of whom passed with the ECG machine but failed using the programmer. On a per lead basis, the ECG machine passes more subjects. It is unknown what the inappropriate shock rate would be if an S-ICD was implanted. Clinical judgment should be used in borderline cases.


Asunto(s)
Desfibriladores Implantables , Electrocardiografía/instrumentación , Análisis de Falla de Equipo , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo
2.
J Interv Card Electrophysiol ; 67(2): 293-301, 2024 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-37344624

RESUMEN

BACKGROUND: The DiamondTemp ablation (DTA) system is a novel temperature-controlled irrigated radiofrequency (RF) ablation system that accurately measures tip-tissue temperatures for real-time power modulation. Lesion morphologies from longer RF durations with the DTA system have not been previously described. We sought to evaluate lesion characteristics of the DTA system when varying the application durations. METHODS: A bench model using porcine myocardium was used to deliver discrete lesions in a simulated clinical environment. The DTA system was power-limited at 50 W with temperature set-points of 50 °C and 60 °C (denoted Group_50 and Group_60). Application durations were randomized with a range of 5-120 s. RESULTS: In total, 280 applications were performed. Steam pops were observed in five applications: two applications at 90 s and three applications at 120 s. Lesion size (depth and maximum width) increased significantly with longer applications, until 60 s for both Group_50 and Group_60 (depth: 4.5 ± 1.2 mm and 5.6 ± 1.3 mm; maximum width: 9.3 ± 2.7mm and 11.2 ± 1.7mm, respectively). As lesions transition from resistive to conductive heating (longer than 10 s), the maximum width progressed in a sub-surface propagation. Using a "Time after Temperature 60 °C" (TaT60) analysis, depths of 2-3 mm occur in 0-5 s and depths plateau at 4.6 ± 0.8 mm between 20 and 30 s. CONCLUSIONS: The DTA system rapidly creates wide lesions with lesion depth increasing over time with application durations up to 60 s. Using a TaT60 approach is a promising ablation guidance that would benefit from further investigation.


Asunto(s)
Ablación por Catéter , Ablación por Radiofrecuencia , Animales , Porcinos , Temperatura , Irrigación Terapéutica , Catéteres , Diseño de Equipo
3.
Heart Rhythm ; 20(10): e175-e264, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37211147

RESUMEN

This international multidisciplinary expert consensus statement is intended to provide comprehensive guidance that can be referenced at the point of care to cardiac electrophysiologists, cardiologists, and other health care professionals, on the management of cardiac arrhythmias in pregnant patients and in fetuses. This document covers general concepts related to arrhythmias, including both brady- and tachyarrhythmias, in both the patient and the fetus during pregnancy. Recommendations are provided for optimal approaches to diagnosis and evaluation of arrhythmias; selection of invasive and noninvasive options for treatment of arrhythmias; and disease- and patient-specific considerations when risk stratifying, diagnosing, and treating arrhythmias in pregnant patients and fetuses. Gaps in knowledge and new directions for future research are also identified.


Asunto(s)
Antiarrítmicos , Arritmias Cardíacas , Embarazo , Femenino , Humanos , Antiarrítmicos/uso terapéutico , Arritmias Cardíacas/terapia , Arritmias Cardíacas/tratamiento farmacológico , Taquicardia/diagnóstico
4.
Circ Arrhythm Electrophysiol ; 15(11): e000084, 2022 11.
Artículo en Inglés | MEDLINE | ID: mdl-36263773

RESUMEN

Arrhythmia and sudden cardiac death remain common in repaired tetralogy of Fallot and affect even those with excellent anatomic repairs. Atrial arrhythmia often has mechanisms different from those in acquired heart disease. Ventricular arrhythmia remains a major source of mortality in repaired tetralogy of Fallot. Noninvasive risk stratification is important to identify patients who may benefit from ablation or primary prevention implantable cardioverter defibrillators. Multiple noninvasive risk factors are associated with ventricular arrhythmia, but no universally accepted risk stratification algorithm exists. The mechanism of ventricular arrhythmia is usually attributable to a consistent and discrete set of slowly conducting anatomic isthmuses related to both the native anatomy and the consequences of the surgical repair, which interact with ventricular remodeling to provide arrhythmic substrate. This substrate can be identified during electroanatomic mapping and prophylactically ablated in appropriate patients. This scientific statement discusses the mechanisms and treatment of arrhythmia in repaired tetralogy of Fallot.


Asunto(s)
Taquicardia Ventricular , Tetralogía de Fallot , Humanos , Tetralogía de Fallot/cirugía , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/etiología , Taquicardia Ventricular/cirugía , American Heart Association , Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/etiología , Arritmias Cardíacas/terapia , Muerte Súbita Cardíaca/etiología , Muerte Súbita Cardíaca/prevención & control
5.
JAMA Cardiol ; 7(2): 175-183, 2022 02 01.
Artículo en Inglés | MEDLINE | ID: mdl-34787643

RESUMEN

Importance: Ventricular tachycardia (VT) is associated with high mortality in patients with cardiac sarcoidosis (CS), and medical management of CS-associated VT is limited by high failure rates. The role of catheter ablation has been investigated in small, single-center studies. Objective: To investigate outcomes associated with VT ablation in patients with CS. Design, Setting, and Participants: This cohort study from the Cardiac Sarcoidosis Consortium registry (2003-2019) included 16 tertiary referral centers in the US, Europe, and Asia. A total of 158 consecutive patients with CS and VT were included (33% female; mean [SD] age, 52 [11] years; 53% with ejection fraction [EF] <50%). Exposures: Catheter ablation of CS-associated VT and, as appropriate, medical treatment. Main Outcomes and Measures: Immediate and short-term outcomes included procedural success, elimination of VT storm, and reduction in defibrillator shocks. The primary long-term outcome was the composite of VT recurrence, heart transplant (HT), or death. Results: Complete procedural success (no inducible VT postablation) was achieved in 85 patients (54%). Sixty-five patients (41%) had preablation VT storm that did not recur postablation in 53 (82%). Defibrillator shocks were significantly reduced from a median (IQR) of 2 (1-5) to 0 (0-0) in the 30 days before and after ablation (P < .001). During median (IQR) follow-up of 2.5 (1.1-4.9) years, 73 patients (46%) experienced VT recurrence and 81 (51%) experienced the composite primary outcome. One- and 2-year rates of survival free of VT recurrence, HT, or death were 60% and 52%, respectively. EF less than 50% and myocardial inflammation on preprocedural 18F-fluorodeoxyglucose positron emission tomography were significantly associated with adverse prognosis in multivariable analysis for the primary outcome (HR, 2.24; 95% CI, 1.37-3.64; P = .001 and HR, 2.93; 95% CI, 1.31-6.55; P = .009, respectively). History of hypertension was associated with a favorable long-term outcome (adjusted HR, 0.51; 95% CI, 0.28-0.92; P = .02). Conclusions and Relevance: In this observational study of selected patients with CS and VT, catheter ablation was associated with reductions in defibrillator shocks and recurrent VT storm. Preablation LV dysfunction and myocardial inflammation were associated with adverse long-term prognosis. These data support the role of catheter ablation in conjunction with medical therapy in the management of CS-associated VT.


Asunto(s)
Antiarrítmicos/uso terapéutico , Cardiomiopatías/terapia , Ablación por Catéter , Muerte Súbita Cardíaca/prevención & control , Sarcoidosis/terapia , Taquicardia Ventricular/cirugía , Adulto , Cardiomiopatías/complicaciones , Cardiomiopatías/diagnóstico por imagen , Cardiomiopatías/fisiopatología , Desfibriladores Implantables , Cardioversión Eléctrica/estadística & datos numéricos , Femenino , Fluorodesoxiglucosa F18 , Corazón/diagnóstico por imagen , Trasplante de Corazón/estadística & datos numéricos , Humanos , Inflamación/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Mortalidad , Análisis Multivariante , Miocardio , Tomografía de Emisión de Positrones , Radiofármacos , Recurrencia , Sarcoidosis/complicaciones , Sarcoidosis/diagnóstico por imagen , Sarcoidosis/fisiopatología , Volumen Sistólico , Taquicardia Ventricular/etiología , Taquicardia Ventricular/fisiopatología , Resultado del Tratamiento
6.
J Cardiovasc Electrophysiol ; 22(10): 1123-8, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-21539642

RESUMEN

INTRODUCTION: Despite advances in ablation of ventricular tachycardia (VT), recognized toxicity of amiodarone, and potential harm of implantable cardioverter defibrillator (ICD) shocks, there appears to be reluctance to pursue catheter ablation. METHODS AND RESULTS: We tested the hypothesis that patients with structural heart disease and VT are referred late for ablation and may have worse outcomes as a result. Consecutive patients with VT and structural heart disease referred to a single center, between January 2008 and April 2009 were studied. Patients with prior VT ablations were excluded. Late referrals were defined as those with 2 or more episodes of VT, separated by at least 1 month. Ninety-eight consecutive patients were analyzed. Ninety-six percent of patients had an ICD implanted prior to ablation, 58% were in VT storm and 67% taking ≥400 mg daily of amiodarone or amiodarone intolerant (10%). Thirty-six patients fit the definition of early referral and 62 late. Overall acute procedural success was achieved in 89%. Amiodarone dose decreased from a mean and median of 559 and 400 mg daily preablation to 98 and 0 postablation (P < 0.01). Mean and median VT episodes decreased from 17 and 6 in the month preceding ablation to 1 and 0 in the 6 months following ablation (P < 0.01). In Kaplan-Meier analysis, the early referral group had superior 1-year VT free survival (P = 0.01). CONCLUSIONS: VT ablation is frequently reserved for patients receiving recurrent ICD shocks despite high dose amiodarone. Stronger consideration should be given to earlier referral for VT ablation in patients with structural heart disease.


Asunto(s)
Ablación por Catéter , Cardiopatías/complicaciones , Taquicardia Ventricular/cirugía , Anciano , Amiodarona/administración & dosificación , Amiodarona/efectos adversos , Antiarrítmicos/administración & dosificación , Antiarrítmicos/efectos adversos , Ablación por Catéter/efectos adversos , Distribución de Chi-Cuadrado , Desfibriladores Implantables , Supervivencia sin Enfermedad , Femenino , Humanos , Estimación de Kaplan-Meier , Modelos Logísticos , Masculino , Persona de Mediana Edad , Selección de Paciente , Pennsylvania , Derivación y Consulta , Estudios Retrospectivos , Medición de Riesgo , Factores de Riesgo , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/etiología , Factores de Tiempo , Resultado del Tratamiento
7.
Heart Fail Clin ; 7(2): 185-94, vii-viii, 2011 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-21439497

RESUMEN

Although most recent investigations into sudden cardiac death prevention in heart failure patients have been focused on primary prevention, secondary indications for defibrillators and medical therapy remain vitally important in this complex patient group. Antiarrhythmic therapy is currently used primarily as adjuvant therapy to implantable defibrillators. Secondary prophylaxis defibrillator trials have shown clear benefit in preventing recurrent sudden cardiac death, despite concern over inappropriate shocks and the potential detrimental effects of appropriate shocks. Device programming for secondary prophylaxis can help ameliorate these issues. This article discusses these issues as well as the continued underuse of defibrillators in specific populations.


Asunto(s)
Antiarrítmicos/uso terapéutico , Insuficiencia Cardíaca/prevención & control , Prevención Secundaria , Desfibriladores Implantables , Insuficiencia Cardíaca/tratamiento farmacológico , Insuficiencia Cardíaca/terapia , Humanos
8.
Stem Cell Reports ; 16(10): 2473-2487, 2021 10 12.
Artículo en Inglés | MEDLINE | ID: mdl-34506727

RESUMEN

Heart failure remains a significant cause of morbidity and mortality following myocardial infarction. Cardiac remuscularization with transplantation of human pluripotent stem cell-derived cardiomyocytes is a promising preclinical therapy to restore function. Recent large animal data, however, have revealed a significant risk of engraftment arrhythmia (EA). Although transient, the risk posed by EA presents a barrier to clinical translation. We hypothesized that clinically approved antiarrhythmic drugs can prevent EA-related mortality as well as suppress tachycardia and arrhythmia burden. This study uses a porcine model to provide proof-of-concept evidence that a combination of amiodarone and ivabradine can effectively suppress EA. None of the nine treated subjects experienced the primary endpoint of cardiac death, unstable EA, or heart failure compared with five out of eight (62.5%) in the control cohort (hazard ratio = 0.00; 95% confidence interval: 0-0.297; p = 0.002). Pharmacologic treatment of EA may be a viable strategy to improve safety and allow further clinical development of cardiac remuscularization therapy.


Asunto(s)
Amiodarona/uso terapéutico , Arritmias Cardíacas/tratamiento farmacológico , Ivabradina/uso terapéutico , Infarto del Miocardio/tratamiento farmacológico , Miocitos Cardíacos/trasplante , Trasplante de Células Madre/efectos adversos , Taquicardia/tratamiento farmacológico , Animales , Antiarrítmicos/uso terapéutico , Línea Celular , Tratamiento Basado en Trasplante de Células y Tejidos/efectos adversos , Modelos Animales de Enfermedad , Combinación de Medicamentos , Humanos , Masculino , Células Madre Pluripotentes/trasplante , Porcinos
9.
Europace ; 12(9): 1347-8, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20558461

RESUMEN

After pacemaker or implantable cardioverter-defibrillator (ICD) implantation, it takes weeks for the leads to scar in place. Occasionally, newly implanted leads dislodge by retracting towards the device pocket. This phenomenon is generally called 'Twiddler's Syndrome,' with the invoked mechanism being patient manipulation of the device pocket. We present a case of a 27-year-old man who had complete retraction of the atrial lead, but not the ventricular lead, after a submuscular dual-chamber ICD implantation. The specifics of this case demonstrate that leads can spontaneously retract during normal arm movement, without any conscious or unconscious device manipulation by the patient. Leads must be firmly secured in the device pocket via their suture sleeves in order to minimize the risk of retraction, regardless of mechanism.


Asunto(s)
Desfibriladores Implantables , Análisis de Falla de Equipo , Distrofia Miotónica , Falla de Prótesis , Adulto , Fluoroscopía , Migración de Cuerpo Extraño/prevención & control , Humanos , Masculino , Distrofia Miotónica/epidemiología , Implantación de Prótesis/métodos , Técnicas de Sutura , Síndrome
10.
Curr Cardiol Rep ; 12(5): 374-81, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20607626

RESUMEN

Paralleling the growth in ablation of complex arrhythmias such as atrial fibrillation and ventricular tachycardia, advanced imaging technologies are becoming more commonplace in the care of the electrophysiology patients. Although intracardiac ultrasound remains the most commonly used imaging technique, advances in real-time MRI may change this in the future. We discuss the current use of intracardiac ultrasound, CT, including rotational angiography, MRI, with an emphasis on delayed-enhancement MRI, and positron emission tomography-CT in advanced ablation procedures. Image integration is emphasized and new technologies such as direct endoscopic visualization are discussed.


Asunto(s)
Ablación por Catéter , Imagen por Resonancia Magnética/instrumentación , Miocardio , Fibrilación Atrial/cirugía , Fibrilación Atrial/terapia , Humanos , Tomografía de Emisión de Positrones/instrumentación , Venas Pulmonares/anatomía & histología , Taquicardia Ventricular/cirugía , Taquicardia Ventricular/terapia , Tomografía Computarizada por Rayos X/instrumentación
12.
J Am Coll Cardiol ; 59(17): 1529-35, 2012 Apr 24.
Artículo en Inglés | MEDLINE | ID: mdl-22516442

RESUMEN

OBJECTIVES: The goal of this study was to evaluate the ability of noninvasive programmed stimulation (NIPS) after ventricular tachycardia (VT) ablation to identify patients at high risk of recurrence. BACKGROUND: Optimal endpoints for VT ablation are not well defined. METHODS: Of 200 consecutive patients with VT and structural heart disease undergoing ablation, 11 had clinical VT inducible at the end of ablation and 11 recurred spontaneously. Of the remaining 178 patients, 132 underwent NIPS through their implantable cardioverter-defibrillator 3.1 ± 2.1 days after ablation. At 2 drive cycle lengths, single, double, and triple right ventricular extrastimuli were delivered to refractoriness. Clinical VT was defined by comparison with 12-lead electrocardiograms and stored implantable cardioverter-defibrillator electrograms from spontaneous VT episodes. Patients were followed for 1 year. RESULTS: Fifty-nine patients (44.7%) had no VT inducible at NIPS; 49 (37.1%) had inducible nonclinical VT only; and 24 (18.2%) had inducible clinical VT. Patients with inducible clinical VT at NIPS had markedly decreased 1-year VT-free survival compared to those in whom no VT was inducible (<30% vs. >80%; p = 0.001), including 33% recurring with VT storm. Patients with inducible nonclinical VT only, had intermediate 1-year VT-free survival (65%). CONCLUSIONS: When patients with VT and structural heart disease have no VT or nonclinical VT only inducible at the end of ablation or their condition is too unstable to undergo final programmed stimulation, NIPS should be considered in the following days to further define risk of recurrence. If clinical VT is inducible at NIPS, repeat ablation may be considered because recurrence over the following year is high.


Asunto(s)
Ablación por Catéter/métodos , Taquicardia Ventricular/mortalidad , Taquicardia Ventricular/terapia , Anciano , Análisis de Varianza , Ablación por Catéter/efectos adversos , Estudios de Cohortes , Desfibriladores Implantables , Electrocardiografía , Femenino , Estudios de Seguimiento , Humanos , Incidencia , Estimación de Kaplan-Meier , Masculino , Persona de Mediana Edad , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Medición de Riesgo , Prevención Secundaria , Índice de Severidad de la Enfermedad , Volumen Sistólico/fisiología , Análisis de Supervivencia , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/cirugía , Factores de Tiempo , Resultado del Tratamiento
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