RESUMEN
Morning report is an important clinical learning activity in many neurological institutions. A long experience of these meetings allows identification of several components to enhance its success. Meetings are best if brief (one or two cases) and held regularly, preferably daily and early in the working day, with full in-person team engagement. A senior clinician should lead the meeting and commit to a single interpretation, without fear of being wrong. Although the environment is relaxed (refreshments typically provided), it is a working meeting and with the essential focus on the patient rather than the learners. The rich learning experience is greatly enhanced by a subsequent confidential email summary and interpretation of the case(s) sent to all participants.
Asunto(s)
Rondas de Enseñanza , Humanos , Rondas de Enseñanza/organización & administración , AprendizajeRESUMEN
We present two historic cases of severe encephalopathy associated with antithyroid antibodies. The first was published by Lord Brain of Eynsham, and the second was from our department's archives. Although both cases are from archival sources, they continue to inform current clinical care. We briefly review the poorly defined entity, Hashimoto's encephalopathy, and discuss diagnostic advances for autoimmune encephalopathy and for Creutzfeldt-Jakob disease. We advocate for giving a trial of corticosteroids to patients with 'encephalopathy, not otherwise specified' while awaiting antibody results or more definitive testing. Our case, initially diagnosed as having Creutzfeldt-Jakob disease, responded remarkably (with video evidence) to a trial of corticosteroids.
Asunto(s)
Autoanticuerpos/sangre , Síndrome de Creutzfeldt-Jakob/sangre , Síndrome de Creutzfeldt-Jakob/diagnóstico , Encefalitis/sangre , Encefalitis/diagnóstico , Enfermedad de Hashimoto/sangre , Enfermedad de Hashimoto/diagnóstico , Encefalopatías/sangre , Encefalopatías/diagnóstico , Síndrome de Creutzfeldt-Jakob/tratamiento farmacológico , Diagnóstico Diferencial , Encefalitis/tratamiento farmacológico , Femenino , Enfermedad de Hashimoto/tratamiento farmacológico , Humanos , Masculino , Metilprednisolona/administración & dosificación , Persona de Mediana EdadRESUMEN
Acute idiopathic hyperammonemia in an adult patient is a life-threatening condition often resulting in a rapid progression to irreversible cerebral edema and death. While ammonia-scavenging therapies lower blood ammonia levels, in comparison, clearance of waste nitrogen from the brain may be delayed. Therefore, we used magnetic resonance spectroscopy (MRS) to monitor cerebral glutamine levels, the major reservoir of ammonia, in a gastric bypass patient with hyperammonemic coma undergoing therapy with N-carbamoyl glutamate and the ammonia-scavenging agents, sodium phenylacetate and sodium benzoate. Improvement in mental status mirrored brain glutamine levels, as coma persisted for 48h after plasma ammonia normalized. We hypothesize that the slower clearance for brain glutamine levels accounts for the delay in improvement following initiation of treatment in cases of chronic hyperammonemia. We propose MRS to monitor brain glutamine as a noninvasive approach to be utilized for diagnostic and therapeutic monitoring purposes in adult patients presenting with idiopathic hyperammonemia.
Asunto(s)
Encéfalo/diagnóstico por imagen , Coma/tratamiento farmacológico , Glutamina/metabolismo , Hiperamonemia/tratamiento farmacológico , Espectroscopía de Resonancia Magnética/métodos , Encéfalo/metabolismo , Coma/etiología , Femenino , Derivación Gástrica/efectos adversos , Glutamatos/uso terapéutico , Humanos , Hiperamonemia/complicaciones , Hiperamonemia/diagnóstico por imagen , Hiperamonemia/metabolismo , Persona de Mediana Edad , Fenilacetatos/uso terapéutico , Benzoato de Sodio/uso terapéutico , Resultado del TratamientoAsunto(s)
Anemia Perniciosa/diagnóstico , Disfunción Cognitiva/etiología , Anciano , Anemia Perniciosa/complicaciones , Anemia Perniciosa/tratamiento farmacológico , Encéfalo/diagnóstico por imagen , Diagnóstico Diferencial , Humanos , Inyecciones Intramusculares , Angiografía por Resonancia Magnética , Imagen por Resonancia Magnética , Masculino , Ácido Metilmalónico/sangre , Examen Neurológico , Equilibrio Postural , Trastornos de la Sensación/etiología , Serodiagnóstico de la Sífilis , Treponema pallidum/inmunología , Vitamina B 12/administración & dosificación , Deficiencia de Vitamina D/complicaciones , Deficiencia de Vitamina D/diagnósticoAsunto(s)
Amebiasis/diagnóstico , Encéfalo/patología , Meningoencefalitis/diagnóstico , Acanthamoeba/aislamiento & purificación , Amebiasis/complicaciones , Análisis Químico de la Sangre , Encéfalo/diagnóstico por imagen , Encéfalo/parasitología , Encefalopatías/inducido químicamente , Cardiomiopatías/complicaciones , Diagnóstico Diferencial , Diplopía/etiología , Resultado Fatal , Humanos , Huésped Inmunocomprometido , Masculino , Meningoencefalitis/complicaciones , Meningoencefalitis/parasitología , Persona de Mediana Edad , Debilidad Muscular/etiología , Sarcoidosis/complicaciones , Sarcoidosis/diagnóstico , Tomografía Computarizada por Rayos XRESUMEN
Neurological symptoms occur in approximately 20% of patients with Sjögren's syndrome, and may be the presenting manifestations of the disease. Here, we review several neurological conditions that can occur in Sjögren's syndrome: sensory ganglionopathy, painful small fibre neuropathy, and transverse myelitis (independently or as part of neuromyelitis optica). We present the symptoms, signs, differential diagnoses, recommended diagnostic evaluation, and treatment of each of these, highlighting the features that should alert neurologists to consider Sjögren's syndrome.
Asunto(s)
Mielitis/etiología , Enfermedades del Sistema Nervioso Periférico/etiología , Síndrome de Sjögren/complicaciones , HumanosRESUMEN
Physicians use heuristics or shortcuts in their decision making to help them sort through complex clinical information and formulate diagnoses efficiently. Practice would come to a halt without them. However, there are pitfalls to the use of certain heuristics, the same ones to which humans are prone in everyday life. It may be possible to improve clinical decision making through techniques that minimize biases inherent in heuristics. Five common clinical heuristics or other sources of cognitive error are illustrated through neurological cases with missed diagnoses, and literature from cognitive psychology and medicine are presented to support the occurrence of these errors in diagnostic reasoning as general phenomena. Articulation of the errors inherent in certain common heuristics alerts clinicians to their weaknesses as diagnosticians and should be beneficial to practice. Analysis of cases with missed diagnoses in teaching conferences might proceed along formal lines that identify the type of heuristic used and of inherent potential cognitive errors. Addressing these cognitive errors by becoming conscious of them is a useful tool in neurologic education and should facilitate a career-long process of continuous self-improvement.
Asunto(s)
Cognición , Errores Diagnósticos/psicología , Enfermedades del Sistema Nervioso/diagnóstico , Neurología , Médicos/psicología , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades del Sistema Nervioso/psicologíaRESUMEN
Some of the most common reasons for metabolic neurologic disturbances in the setting of a general hospital are frequently encountered electrolyte and related osmolality disorders. Hyperosmolality is usually related to hypernatremia and/or hyperglycemia. Identifying the cause and carefully calculating the water deficit is crucial to appropriate management. Hyponatremia may be hypertonic, isotonic, or hypotonic. When hypotonic, it may be hypervolemic, euvolemic, or hypovolemic in nature. Determining the precise nature of the hyponatremia allows the clinician to focus the therapy appropriately. The rate of development of hyponatremia is crucial to safe and appropriate treatment. In acutely developing hyponatremia, hypertonic saline is required, whereas in slowly developing hyponatremia, water restriction and slow correction is required to avoid the syndrome of osmotic demyelination. Disorders of potassium metabolism are also common electrolyte disorders seen in the general hospital. Appropriate diagnosis and management of hyperkalemia and hypokalemia are also discussed.
Asunto(s)
Encefalitis/etiología , Hiperpotasemia/complicaciones , Hipernatremia/complicaciones , Hipopotasemia/complicaciones , Hiponatremia/complicaciones , Desequilibrio Ácido-Base/complicaciones , Animales , Humanos , Síndrome de Secreción Inadecuada de ADH/complicaciones , Equilibrio Hidroelectrolítico/fisiología , Desequilibrio Hidroelectrolítico/complicacionesRESUMEN
Kidney failure is one of the leading causes of disability and death and one of the most disabling features of kidney failure and dialysis is encephalopathy. This is probably caused by the accumulation of uremic toxins. Other important causes are related to the underlying disorders that cause kidney failure, particularly hypertension. The clinical manifestations of uremic encephalopathy include mild confusional states to deep coma, often with associated movement disorders, such as asterixis. Most nephrologists consider cognitive impairment to be a major indication for the initiation of renal replacement therapy with dialysis with or without subsequent transplantation. Sleep disorders, including Ekbom's syndrome (restless legs syndrome) are also common in patients with kidney failure. Renal replacement therapies are also associated with particular neurologic complications including acute dialysis encephalopathy and chronic dialysis encephalopathy, formerly known as dialysis dementia. The treatments and prevention of each are discussed.