1.
Bioorg Med Chem Lett
; 17(24): 6691-6, 2007 Dec 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17976986
RESUMEN
This paper reports the synthesis and biological activity of a novel series of aryl-morpholine dopamine receptor agonists. Several compounds show high levels of functional selectivity for the D3 over the D2 dopamine receptor. Compound 26 has >1000-fold functional selectivity and has been successfully progressed in vivo using an intranasal delivery route.