1.
Bioorg Med Chem Lett
; 17(10): 2718-22, 2007 May 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17382544
RESUMEN
We have previously reported a novel class of tetrahydroindazoles that display potency against a variety of Gram-positive and Gram-negative bacteria, potentially via interaction with type II bacterial topoisomerases. Herein are reported SAR investigations of this new series. Several compounds possessing broad-spectrum potency were prepared. Further, these compounds exhibit activity against multidrug-resistant Gram-positive microorganisms equivalent to that against susceptible strains.