RESUMEN
The combined administration of tranylcypromine (TCP) and ethanol to rats produced both a marked increase in general locomotion such as walking and running and the appearance of repetitive stereotyped head and trunk weaving, forepaw padding, and circling movements. Pretreatment with p-chlorophenylalanine (pCPA) abolished the stereotyped behaviors. In contrast, animals pretreated with alpha-methyl-p-tyrosine (AMPT) were virtually indistinguishable from those receiving only TCP + ethanol, except for a decrease in running behaviors. The above results are consistent with a serotonergic mediation of these specific stereotypes. The mechanisms by which TCP + ethanol might produce these effects are discussed.
Asunto(s)
Conducta/efectos de los fármacos , Etanol/farmacología , Actividad Motora/efectos de los fármacos , Conducta Estereotipada/efectos de los fármacos , Tranilcipromina/farmacología , Animales , Humanos , Masculino , Metiltirosinas/farmacología , RatasRESUMEN
Alkali metal cations were given in varying doses over 14 days to CF-1, male mice, isolated for 4 weeks prior to testing for isolation-induced fighting. Lithium and cesium in doses of 4.5 and 6.0 meq/kg reduced the duration of isolation-induced aggression in a 15 min test period when compared with controls. Toxicity was evident in the cesium-treated, but not the lithium-treated mice. No enhancement of aggression was seen in the rubidium-treated group.