[Plasma levels of endogenous opioid peptides in patients with chronic colitis]. / Soderzhanie éndogennykh opioidnykh peptidov v plazme krovi bo'lnykh khronicheskim kolitom.

Abnormal content and proportion of leucin-and methionine-enkephalins and beta-endorphin were found in blood plasma of chronic colitis sufferers. Nonspecific ulcerative colitis was associated with relevant peptides deficiency varying with the disease gravity, whereas in catarrhal colitis the peptides concentration was significantly elevated. Endogenous opioid peptides seem to play a role in pathogenesis of various colitis forms.

[Taktivin treatment of immunologic disorders in patients with nonspecific ulcerative colitis]. / Korrektsiia taktivinom immunnykh narushenii u bol'nykh nespetsificheskim iazvennym kolitom.

Nonspecific ulcerative colitis (NSUC) varying in severity was treated by conventional methods (49 patients) against combined treatment including tactivin (93 patients). All the patients were examined immunologically at admission and in the course of the treatment. The drug produced a positive effect on immunological status, treatment effectiveness rose, NSUC exacerbations rapidly attenuated.

[Changes in prostaglandin levels in the blood of patients with various forms of chronic colitis before and after treatment]. / Izmenenie urovnia prostaglandinov v krovi u bol'nykh s razlichnymi formami khronicheskogo kolita do i posle lecheniia.

Plasma prostaglandins have been studied in 306 patients with chronic nonspecific ulcerative colitis. These were found elevated and related to the disease gravity. Treatment succeeded in normalizing prostaglandin, concentrations only in mild ulcerative colitis. In catarrhal pancolitis PGE levels moderately increased before treatment returned to normal at the end of it. In spastic colon pretreatment lack of PGF2 alpha persisted. Evaluation of plasma prostaglandins can serve an additional diagnostic procedure to improve pathogenetic therapy of chronic colitis.