RESUMEN
Is established that at intestinal dysbacteriosis in the organism of experimental animals develop reactions of inflammatory type (early and late), leading to an accumulation in the blood serum of humoral immunity factors, blocking reactions mediated by lymphocytes ormacrophages, while maintaining their cytotoxic activity. Introduction of animals of tne probiotic endosporin promotes restoration of quantitative and qualitative indicators of intestinal microbiocenosis and the normalization of the immune system.
Asunto(s)
Bacillus , Colon/efectos de los fármacos , Disbiosis/tratamiento farmacológico , Inmunidad Humoral/efectos de los fármacos , Probióticos/uso terapéutico , Animales , Colon/inmunología , Colon/metabolismo , Pruebas Inmunológicas de Citotoxicidad , Modelos Animales de Enfermedad , Disbiosis/inmunología , Disbiosis/microbiología , Linfocitos/efectos de los fármacos , Linfocitos/inmunología , Activación de Macrófagos/efectos de los fármacos , Activación de Macrófagos/inmunología , Macrófagos/efectos de los fármacos , Macrófagos/inmunología , Ratones Endogámicos BALB C , Consorcios Microbianos/efectos de los fármacos , Probióticos/administración & dosificación , Resultado del TratamientoRESUMEN
Sixty five patients with peritonitis were examined and divided into two groups. The operative intervention in all the patients included transnasal intubation of the small intestine. The basic enteral therapy used in the first group of patients was made with the glucose-saline solution and transition to a balanced polysubstrate mixture "nutrient standard" with the increasing concentration. For the patients of the second group a special program was developed for enteral therapy in which glutamine and pectine were included in the glucose-saline solution as well as nutrient mixtures containing middle chain triglycerides. Active decompression of the small intestine followed by the enteral administration of the nutrient mixtures facilitated quicker correction of the intestinal insufficiency in patients with severe forms of peritonitis.