Optimising curve fitting techniques to look for standardisation of the analysis of defocus curves derived from multifocal intraocular lenses.

INTRODUCTION: To establish the most appropriate curve fitting method to allow accurate comparison of defocus curves derived from intraocular lenses (IOLs). METHODS: Defocus curves were plotted in five IOL groups (monofocal, extended depth of focus, refractive bifocal, diffractive bifocal and trifocal). Polynomial curves from 2nd to 11th order and cubic splines were fitted. Goodness of fit (GOF) was assessed using five methods: least squares, coefficient of determination (R2adj ), Akaike information criteria (AIC), visual inspection and Snedecor and Cochran. Additional defocus steps at -2.25 D and -2.75 D were measured and compared to the calculated visual acuity (VA) values. Area under the defocus curve and range of focus were also compared. RESULTS: Goodness of fit demonstrated variable results, with more lenient methods such as R2adj leading to overfitting and conservative methods such as AIC resulting in underfitting. Furthermore, conservative methods diminished the inflection points resulting in an underestimation of VA. Polynomial of at least 8th order was required for comparison of area methods, but overfitted the EDoF and monofocal groups; the spline curve was consistent for all IOLs and methods. CONCLUSIONS: This study demonstrates the inherent difficulty of selecting a single polynomial function. The R2 method can be used cautiously along with visual inspection to guard against overfitting. Spline curves are suitable for all IOLs, guarding against the issues of overfitting. Therefore, for analysis of the defocus profile of IOLs, the fitting of a spline curves is advocated and should be used wherever possible.

Test-Retest Reliability of Measuring the Vertebral Arterial Blood Flow Velocity in People With Cervicogenic Dizziness.

OBJECTIVES: The purpose of this study was to determine the within-session and between-sessions reliability of measuring the vertebral artery blood flow velocities in people with cervicogenic dizziness using Doppler ultrasound at both upper and lower cervical levels. METHODS: Outcome measures were taken on 2 occasions 3 weeks apart with no active treatment provided in between the assessments on 12 participants. Pulsed-wave Doppler ultrasound was used to quantify time-averaged mean velocities through the vertebral artery at upper cervical (C0-1) and lower cervical vertebrae (C5-6). The clinical outcome measures were also recorded in people with cervicogenic dizziness. The intraclass correlation coefficient (ICC) was used to determine the within-session and between-session repeatability. Paired t test was used to determine the differences in the time-averaged mean velocities of blood flow at the same site of the vertebral artery and the clinical outcome measures in 2 sessions 3 weeks apart. RESULTS: In people with cervicogenic dizziness, there was no significant change in both clinical outcome measures and the time-averaged mean velocities when the patients were measured 3 weeks apart (P > .05). This study identified good within-session (ICC: 0.903-0.967) and between-session (ICC: 0.922-0.984) repeatability in measuring the vertical blood flow velocities in patients with cervicogenic dizziness when the clinical outcome measures were unchanged. CONCLUSIONS: This study supports the use of Doppler ultrasound to identify changes in mean vertebral arterial blood flow velocities before and after intervention in people with cervicogenic dizziness in future studies.

The immediate effect of posteroanterior mobilization on reducing back pain and the stiffness of the lumbar spine.

OBJECTIVE: To study the immediate effect of posteroanterior mobilization on back pain and the associated biomechanical changes in the lumbar spine. DESIGN: An experimental between-group study. SETTING: A biomechanics laboratory. PARTICIPANTS: Subjects with low back pain (n=19) and healthy subjects (n=20). INTERVENTIONS: Grade III posteroanterior mobilization (3 cycles of 60s) was applied at the L4 level in people with or without back pain on 1 occasion. MAIN OUTCOME MEASURES: Pain intensity, active lumbar range of motion, the magnitude of the posteroanterior mobilization loads, bending stiffness of the lumbar spine, and the lordotic curvature of the lumbar spine before and after 3 cycles of posteroanterior mobilization. RESULTS: The magnitude of pain of the patients was found to decrease significantly after posteroanterior mobilization treatment. There was also a significant decrease in the bending stiffness of the lumbar spine of the patients, which was derived from the posteroanterior load and the associated change in spine curvature. The stiffness was restored to a level that was similar to that of the asymptomatic subjects. A strong correlation was found between the magnitude of pain and the bending stiffness of the spine before (r=.89) and after posteroanterior mobilization (r=.98). CONCLUSIONS: Posteroanterior mobilization was found to bring about immediate desirable effects in reducing spinal stiffness and the magnitude of back pain. The restoration of the mechanical properties of the spine may be a possible mechanism that explains the improvement in pain after manual therapy.

Efficacy of static stretching and proprioceptive neuromuscular facilitation stretch on hamstrings length after a single session.

A number of studies have investigated the efficacy of several repetitions of proprioceptive neuromuscular facilitation stretching (PNF) and static stretching (SS). However, there is limited research comparing the effects of a single bout of these stretching maneuvers. The aim of this study was to compare the effectiveness of a single bout of a therapist-applied 30-second SS vs. a single bout of therapist-applied 6-second hamstring (agonist) contract PNF. Forty-five healthy subjects between the ages of 21 and 35 were randomly allocated to 1 of the 2 stretching groups or a control group, in which no stretching was received. The flexibility of the hamstring was determined by a range of passive knee extension, measured using a universal goniometer, with the subject in the supine position and the hip at 90° flexion, before and after intervention. A significant increase in knee extension was found for both intervention groups after a single stretch (SS group = 7.53°, p < 0.01 and PNF group = 11.80°, p < 0.01). Both interventions resulted in a significantly greater increase in knee extension when compared to the control group (p < 0.01). The PNF group demonstrated significantly greater gains in knee extension compared to the SS group (mean difference 4.27°, p < 0.01). It can be concluded that a therapist applied SS or PNF results in a significant increase in hamstring flexibility. A hamstring (agonist) contract PNF is more effective than an SS in a single stretching session. These findings are important to physiotherapists or trainers working in clinical and sporting environments. Where in the past therapists may have spent time conducting multiple repetitions of a PNF and an SS, a single bout of either technique may be considered just as effective. A key component of the study methodology was the exclusion of a warm-up period before stretching. Therefore, the findings of efficacy of a single PNF are of particular relevance in sporting environments and busy clinical settings where time may be limited.

Difference in the running biomechanics between preschoolers and adults.

BACKGROUND: High vertical loading rate is associated with a variety of running-related musculoskeletal injuries. There is evidence supporting that non-rearfoot footstrike pattern, greater cadence, and shorter stride length may reduce the vertical loading rate. These features appear to be common among preschoolers, who seem to experience lower running injury incidence, leading to a debate whether adults should accordingly modify their running form. OBJECTIVE: This study sought to compare the running biomechanics between preschoolers and adults. METHODS: Ten preschoolers (4.2±1.6 years) and ten adults (35.1±9.5 years) were recruited and ran overground with their usual shoes at a self-selected speed. Vertical average (VALR) and vertical instantaneous loading rate (VILR) were calculated based on the kinetic data. Footstrike pattern and spatiotemporal parameters were collected using a motion capture system. RESULTS: There was no difference in normalized VALR (p=0.48), VILR (p=0.48), running speed (p=0.85), and footstrike pattern (p=0.29) between the two groups. Preschoolers demonstrated greater cadence (p<0.001) and shorter normalized stride length (p=0.01). CONCLUSION: By comparing the kinetic and kinematic parameters between children and adults, our findings do not support the notion that adults should modify their running biomechanics according to the running characteristics in preschoolers for a lower injury risk.

The effect of closed-kinetic chain exercises and open-kinetic chain exercise on the muscle activity of vastus medialis oblique and vastus lateralis.

Patellofemoral pain syndrome (PFPS) is one of the most prevalent musculoskeletal conditions of the lower limb. The muscle imbalance between the vastus medialis oblique (VMO) and vastus lateralis (VL) muscles is one of the main factors leading to the development of PFPS. The disparity in research and the necessity to add to the existing literature base led to the development of this study. The aim of this study was to investigate the effect of 2 closed kinetic chain exercises and 1 open kinetic chain exercise on VMO and VL muscle activity. Twenty-two healthy asymptomatic individuals participated in this study. The surface electromyography (EMG) of VMO and VL was measured and used to calculate the VMO:VL ratio during 3 different quadriceps-strengthening exercises (a double leg squat with isometric hip adduction exercise, an open kinetic chain knee extension exercise, and a lunge exercise). The double leg squat with isometric hip adduction exercise was shown to produce a significantly greater VMO:VL ratio (1.14:1) than the other 2 exercises (p = 0.015 and p = 0.005). The open kinetic chain knee extension exercises produced significantly greater activation of VL than the lunge exercise (p = 0.001 and p = 0.036). The lunge exercise produced the VMO:VL ratio (1.18:1) closest to the idealized ratio of 1:1. Potential clinical recommendations can be made proposing the lunge exercise as a key tool in early rehabilitation when restoring preferential VMO:VL ratio is essential. The double leg squat with isometric hip adduction exercise would be useful in maintaining correct patella tracking and selectively strengthening VMO.

Energy transfer across the lumbosacral and lower-extremity joints in patients with low back pain during sit-to-stand.

OBJECTIVE: To examine the transfer of energy through the pelvis and the lower limb during sit-to-stand (STS) in low back pain (LBP) subjects with or without a straight-leg raise sign. DESIGN: Cross-sectional. SETTING: Biomechanics laboratory. PARTICIPANTS: Three groups, each of 20 subjects, participated. The first group consisted of asymptomatic subjects, and the other 2 groups of consisted of LBP subjects (duration between 7 days and 12 weeks) with and without a straight-leg raise sign. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The work done and the power of the pelvis, thigh, and leg segments during STS were determined. RESULTS: Energy was transferred from the pelvis to the thigh segment and then to the leg segment, and this was achieved mainly by passive mechanisms. The power flow of the pelvis segment was significantly decreased in subjects with LBP. Although the power of the lower-limb segments was decreased, the total work done of these segments was increased. CONCLUSIONS: STS is a more energy-demanding and less efficient task for subjects with LBP, either with or without a positive straight-leg raise sign. Such increases in energy demand may further exacerbate back pain, and treatment should be developed to restore a more efficient energy transfer pattern.

Gait Retraining for the Reduction of Injury Occurrence in Novice Distance Runners: 1-Year Follow-up of a Randomized Controlled Trial.

BACKGROUND: The increasing popularity of distance running has been accompanied by an increase in running-related injuries, such that up to 85% of novice runners incur an injury in a given year. Previous studies have used a gait retraining program to successfully lower impact loading, which has been associated with many running ailments. However, softer footfalls may not necessarily prevent running injury. PURPOSE: To examine vertical loading rates before and after a gait retraining program and assess the effectiveness of the program in reducing the occurrence of running-related injury across a 12-month observation period. STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: A total of 320 novice runners from the local running club completed this study. All the participants underwent a baseline running biomechanics evaluation on an instrumented treadmill with their usual running shoes at 8 and 12 km/h. Participants were then randomly assigned to either the gait retraining group or the control group. In the gait retraining group (n = 166), participants received 2 weeks of gait retraining with real-time visual feedback. In the control group (n = 154), participants received treadmill running exercise but without visual feedback on their performance. The training time was identical between the 2 groups. Participants' running mechanics were reassessed after the training, and their 12-month posttraining injury profiles were tracked by use of an online surveillance platform. RESULTS: A significant reduction was found in the vertical loading rates at both testing speeds in the gait retraining group ( P < .001, Cohen's d > 0.99), whereas the loading rates were either similar or slightly increased in the control group after training ( P = .001 to 0.461, Cohen's d = 0.03 to -0.14). At 12-month follow-up, the occurrence of running-related musculoskeletal injury was 16% and 38% in the gait retraining and control groups, respectively. The hazard ratio between gait retraining and control groups was 0.38 (95% CI, 0.25-0.59), indicating a 62% lower injury risk in gait-retrained runners compared with controls. CONCLUSION: A 2-week gait retraining program is effective in lowering impact loading in novice runners. More important, the occurrence of injury is 62% lower after 2 weeks of running gait modification. Registration: HKUCTR-1996 (University of Hong Kong Clinical Trials Registry).

The effect of elastic therapeutic taping on lumbar extensor isokinetic performance.

OBJECTIVES: To investigate the effects of elastic therapeutic tape when applied overlaying the lumbar extensors on different measures of muscle performance, compared to a placebo taping technique and a no-tape control. DESIGN: A cross-sectional experimental study. SETTING: A biomechanics laboratory. PARTICIPANTS: Twenty one participants received three taping conditions in a randomised order: elastic therapeutic tape, a placebo tape and a no-tape control. Peak torque, the time taken to reach peak torque and peak velocity were measured using an isokinetic dynamometer. MAIN OUTCOME MEASURES: Concentric lumbar extension peak torque at 60°/s, time taken to reach peak torque and peak velocity was measured using an isokinetic dynamometer. Friedman's test and post-hoc Wilcoxon signed-rank test were used to determine the statistical differences between the three taping conditions. Level of signicance was set at 0.05.fi. RESULTS: A statistically significant improvement in peak lumbar extensor torque was observed when comparing elastic therapeutic tape with the no-tape control (p < 0.05). However, there was no significant differences in time taken to reach peak torque and peak velocity (p > 0.05). CONCLUSIONS: Results demonstrate that the application of elastic therapeutic tape overlaying the primary lumbar extensors significantly improves the maximal lumbar extension peak torque in healthy, asymptomatic adults.

Humeral elevation reduces the dynamic control ratio of the shoulder muscles during internal rotation.

OBJECTIVES: To determine the differences in the dynamic control ratio of the glenohumeral joint rotators, during internal rotation at 20° and 60° of humeral elevation in the scapular plan. Dynamic control ratio (DCR) is defined as the ratio between eccentric action of the lateral rotators and the concentric action of the medial rotators. DESIGN: A cross-sectional laboratory study. METHODS: Thirty asymptomatic participants (men n=14, women n=16, mean age=29.4±8.9years, BMI: 24.1±5.4) were tested. Peak torque generated by the concentric action of the MR and the eccentric action of the LR of the shoulder joint and the DCR were evaluated on the dominant arm using an isokinetic dynamometer at 20° and 60° of humeral elevation at a speed of 20°/s. RESULTS: There was a significant decrease in the DCR at 60° humeral elevation when compared to 20° humeral elevation (p<0.05). This decrease was due to the significant decrease in eccentric peak torques at 60° humeral elevation when compared to 20° (p<0.05). However, there was no significant difference in the concentric peak torques between 20° and 60° (p>0.05). CONCLUSIONS: The significant decrease in the DCR as a consequence of a decrease in the eccentric peak torque of the LR when the humerus is in a more elevated position suggests that the introduction of humeral elevation can be used as a progression for improving the eccentric action of the shoulder LR and subsequently the dynamic control of the shoulder.

Comparison of reliability and repeatability of corneal curvature assessment with six keratometers.

BACKGROUND: Keratometric methodology varies between instruments and the differences may have a clinical impact. We investigated the agreement and reproducibility of six keratometers. METHODS: Keratometry was performed on 100 subjects at two separate sessions with IOLMaster 500, Pentacam, OPD scanner, Medmont E300, Javal-Schiøtz and TMS-5. A second observer assessed 30 subjects to determine inter-observer variability. A single individual was assessed on 10 separate sessions to determine intra-observer variability. Data were analysed using coefficient of variation (CV) and intra-class correlation coefficient (ICCC) for intra-observer variation. Inter-observer concordance was evaluated by the ICCC. Bland-Altman plots, Pearson's correlation coefficient and repeated measures analysis of variance were used to assess agreement of data produced by the instruments. RESULTS: OPD scanner and Javal-Schiøtz mean spherical equivalent (MSE) results were systematically different (p < 0.001) from other instruments (flatter and steeper, respectively). J0 /J45 were similar for all instruments (p < 0.05). Bland-Altman comparison plots indicated that Pentacam and IOLMaster demonstrated greatest level of agreement (ICC results MSE = 0.992, J0 = 0.934 and J45 = 0.890). Agreement (ICC) between observers for MSE ranged from 0.955 to 0.995 for all instruments; lower levels of agreement were found for J0 /J45 (0.289 to 0.901). IOLMaster showed greatest correlation and Medmont the lowest. All instruments showed high intra-observer repeatability of MSE (CV 0.1 to 0.3 per cent). The J0 /J45 readings showed greater variability (CV range 8.8 to 57.6 per cent). CONCLUSION: When considering MSE alone IOLMaster, Pentacam, OPD scan and Medmont may be considered interchangeable; however, assessment of astigmatism shows greater variability between instruments, sessions and observers.

Tibial nerve excursion during lumbar spine and hip flexion measured with diagnostic ultrasound.

Ultrasound imaging provides a method for non-invasive in vivo measurement of nerve motion resulting from joint movement. This study measured the proximal excursion of the tibial branch of the sciatic nerve at the popliteal fossa during forward bending in healthy subjects. Long-axis image sequences of the nerve were analysed using frame-by-frame cross-correlation software that calculated the longitudinal and axial movement of the nerve. Proximal excursion was calculated from the hypotenuse of these values. The mean proximal excursion recorded was 12.2 mm (SD 2.2 mm, n = 24). The reliability of three repeat measurements was found to be excellent (ICC 0.97, 95% CI 0.93-0.99; SEM 0.7 mm, n = 21). The protocol described provides a reliable method for analysing tibial nerve movement that could prove useful in future clinical studies.

Back pain is associated with changes in loading pattern throughout forward and backward bending.

STUDY DESIGN: Experimental study to determine the kinetics of the lumbar spine (LS) and hips during forward and backward bending. OBJECTIVE: To investigate the effects of back pain, with and without a positive straight leg raise (SLR) sign, on the loading patterns in the LS and hip during forward and backward bending. SUMMARY OF BACKGROUND DATA: Forward and backward bending are important components of many functional activities and are part of routine clinical examination. However, there is a little information about the loading patterns during forward and backward bending in people with back pain with or without a positive SLR sign. METHODS: Twenty asymptomatic participants, 20 back pain participants, and 20 participants with back pain and a positive SLR sign performed 3 continuous cycles of forward and backward bending. Electromagnetic sensors were attached to body segments to measure their kinematics while 2 nonconductive force plates gathered ground reaction force data. A biomechanical model was used to determine the loading pattern in LS and hips. RESULTS: Although the loading on the LS at the end of the range decreased significantly, the loading at the early and middle ranges of forward bending actually increased significantly in people with back pain, especially in those with positive SLR sign. This suggests that resistance to movement is significantly increased in people with back pain during this movement. CONCLUSION: This study suggested that it is not sufficient to study the spine at the end of range only, but a complete description of the loading patterns throughout the range is required. Although the maximum range of motion of the spine is reduced in people with back pain, there is a significant increase in the moment acting through the range, particularly in those with a positive SLR sign.

Movement coordination of the lumbar spine and hip during a picking up activity in low back pain subjects.

The effect of low back pain, with or without nerve root signs, on the joint coordination and kinematics of the lumbar spine and hips during everyday activities, such as picking up an object from the floor, are largely unknown. An experimental study was designed to compare lumbar spine and hip joint kinematics and coordination in subjects with and without sub-acute low back pain, while picking up an object in a sitting position. A three-dimensional real-time electromagnetic tracking device was used to measure movements of the lumbar spine and hips. Sixty participants with subacute low back pain, with or without straight leg raise signs, and twenty healthy asymptomatic participants were recruited. The ranges of motions of lumbar spine and hips were determined. Movement coordination between the two regions was examined by cross-correlation. Results showed that mobility was significantly reduced in subjects with back pain, who compensated for limited motion through various strategies. The contribution of the lumbar spine relative to that of the hip was, however, found to be similar in all groups. The lumbar spine-hip joint coordination was substantially altered in subjects with back pain, in particular, those with a positive straight leg raise sign. We conclude that changes in the lumbar and hip kinematics were related to back pain and limitation in straight leg raise. Lumbar-hip coordination was mainly affected by the presence of positive straight leg raise sign when picking up an object in a sitting position.

Three-dimensional kinetics of the lumbar spine and hips in low back pain patients during sit-to-stand and stand-to-sit.

STUDY DESIGN: Experimental, biomechanical study to determine the kinetics of the lumbar spine and hips during sit-to-stand and stand-to-sit. OBJECTIVE: To investigate the effects of back pain, with and without limitation in straight leg raise, on the joint moment and power of the lumbar and hips during sit-to-stand and stand-to-sit. SUMMARY OF BACKGROUND DATA: Movements of the lumbar spine and hips, and their coordination have been reported to be affected by the presence of low back pain (LBP), especially in those with a positive straight leg raise. However, the literature has no information concerning moment and power characteristics of the lumbar spine and hips during sit-to-stand and stand-to-sit in such patients. METHODS: Twenty asymptomatic subjects, 20 LBP patients, and 20 patients with LBP and a positive straight leg raise sign were requested to perform the sit-to-stand and stand-to-sit activities. Electromagnetic sensors were attached to the body segments to measure their kinematics while 2 nonconductive force plates gathered ground reaction force data. Biomechanical models were used to determine the muscle moments and power at the lumbosacral (L5/S1) joint and hips. RESULTS: Muscle moments acting at the lumbar spine and hip in the sagittal plane were found to decrease in subjects with LBP, but there were significant increases in moments in other planes of motion. The power patterns of the spine and hips were also significantly altered, particularly in subjects with a positive straight leg raise sign. CONCLUSIONS: Back pain subjects exhibit compensatory movements and altered load sharing strategies during the sit-to-stand and stand-to-sit activities. Exercise therapy should take account of these changes so that the normal kinematic and kinetic characteristics of the spine and hips can be restored.

Symptomatic and asymptomatic movement coordination of the lumbar spine and hip during an everyday activity.

STUDY DESIGN: This experimental study analyzed the movements of the lumbar spine and hip while putting on a sock. OBJECTIVES: To examine differences in kinematics and coordination of the lumbar and hip movements in subjects with and without subacute low back pain. SUMMARY OF BACKGROUND DATA: There is no information on the coordination of movements of lumbar spine and hips during activities of daily living such as putting on a sock. The effect of low back pain, with or without nerve root signs, is unknown. METHODS: A real-time three-dimensional electromagnetic tracking device was used to measure movements of the lumbar spine and hips in 60 subacute low back pain subjects with or without straight leg raise (SLR) signs and 20 asymptomatic subjects. Movement coordination between the two regions was examined by cross-correlation. RESULTS: Mobility was significantly reduced in back pain subjects. Symptomatic subjects compensated for limited motion through various strategies, but in all cases the contribution of the lumbar spine relative to that of the hip was significantly reduced. The lumbar spine-hip joint coordination was substantially altered in back pain subjects, in particular, when putting on a sock on the side with positive SLR sign. CONCLUSION: Changes in the lumbar and hip kinematics when putting on a sock were related to back pain and limitation in SLR. Low back pain will affect lumbar-hip coordination.

Effect of low back pain on the kinematics and joint coordination of the lumbar spine and hip during sit-to-stand and stand-to-sit.

STUDY DESIGN: Experimental study to describe lumbar spine and hip joint movements during sit-to-stand and stand-to-sit. OBJECTIVES: To examine differences in the kinematics and joint coordination of the lumbar spine and hips during sit-to-stand and stand-to-sit between healthy subjects and patients with subacute low back pain (LBP). SUMMARY OF BACKGROUND DATA: There is a paucity of information on the coordination of movements of lumbar spine and hips during sit-to-stand and stand-to-sit. The effect of LBP, with or without nerve root signs, is largely unknown. METHODS: A three-dimensional real-time electromagnetic tracking device was used to measure movements of the lumbar spine and hips during sit-to-stand and stand-to-sit. Sixty subacute LBP participants with or without straight leg raise signs and 20 healthy asymptomatic participants were recruited. The kinematic patterns of lumbar spine and hips were analyzed. Coordination between the two joints was studied by relative phase angle analysis. RESULTS: The mobility of the spine and hips was significantly limited in back pain subjects. It was observed that LBP subjects employed various strategies to compensate for the limited motions at the hips and lumbar spine. The contribution of the lumbar spine relative to that of the hip was found to be reduced for subjects with LBP. The lumbar spine-hip joint coordination was significantly altered in back pain subjects, in particular, those with positive straight leg raise sign. CONCLUSION: Back pain was related to changes in the kinematics and coordination of the lumbar spine and hips during sit-to-stand and stand-to-sit. Assessment of back pain patients should include kinematic analysis of the hips as well as the spine.