RESUMEN
OBJECTIVE: Type 1 diabetes (T1D) screening programmes testing islet autoantibodies (IAbs) in childhood can reduce life-threatening diabetic ketoacidosis. General population screening is required to detect the majority of children with T1D, since in >85% there is no family history. Age 3-5 years has been proposed as an optimal age for a single screen approach. DESIGN: Capillary samples were collected from children attending their preschool vaccination and analysed for IAbs to insulin, glutamic acid decarboxylase, islet antigen-2 and zinc transporter 8 using radiobinding/luciferase immunoprecipitation system assays. Acceptability was assessed using semistructured interviews and open-ended postcard questionnaires with parents. SETTING: Two primary care practices in Oxfordshire, UK. MAIN OUTCOME MEASURES: The ability to collect capillary blood to test IAbs in children at the routine preschool vaccination (3.5-4 years). RESULTS: Of 134 parents invited, 66 (49%) were recruited (median age 3.5 years (IQR 3.4-3.6), 26 (39.4%) male); 63 provided a sample (97% successfully), and one participant was identified with a single positive IAb. Parents (n=15 interviews, n=29 postcards) were uniformly positive about screening aligned to vaccination and stated they would have been less likely to take part had screening been a separate visit. Themes identified included preparedness for T1D and the long-term benefit outweighing short-term upset. The perceived volume of the capillary sample was a potential concern and needs optimising. CONCLUSIONS: Capillary IAb testing is a possible method to screen children for T1D. Aligning collection to the preschool vaccination visit can be convenient for families without the need for an additional visit.
Asunto(s)
Autoanticuerpos , Diabetes Mellitus Tipo 1 , Tamizaje Masivo , Humanos , Diabetes Mellitus Tipo 1/inmunología , Diabetes Mellitus Tipo 1/diagnóstico , Autoanticuerpos/sangre , Masculino , Preescolar , Femenino , Tamizaje Masivo/métodos , Vacunación , Proteínas Tirosina Fosfatasas Clase 8 Similares a Receptores/inmunología , Islotes Pancreáticos/inmunología , Padres , Prueba de Estudio Conceptual , Transportador 8 de Zinc/inmunología , Glutamato Descarboxilasa/inmunologíaRESUMEN
The Paediatric Acute Care Conference (PACC) is an annual conference organised by APLS Australia to advance paediatric acute care topics for clinicians in pre-hospital medicine, EDs, acute paediatrics, intensive care and anaesthesia. The PACC 2018 was held in Hobart, Tasmania. We provide a summary of some of the presentations.
Asunto(s)
Cuidados Críticos , Medicina de Emergencia , Adolescente , Factores de Edad , Niño , Congresos como Asunto , Cuidados Críticos/métodos , Medicina de Emergencia/métodos , HumanosRESUMEN
The Paediatric Acute Care Conference (PACC) is an annual conference organised by Advanced Paediatric Life Support Australia to advance paediatric acute care topics for clinicians in pre-hospital medicine, EDs, acute paediatrics, intensive care and anaesthesia. The PACC 2016 was held at Glenelg, Adelaide, Australia. We provide a summary of some of the presentations.
Asunto(s)
Congresos como Asunto/tendencias , Unidades de Cuidado Intensivo Pediátrico/organización & administración , Australia , Humanos , Recursos HumanosRESUMEN
The Paediatric Acute Care Conference (PACC) is an annual conference organised by Advanced Paediatric Life Support (APLS) Australia to advance paediatric acute care topics for clinicians in pre-hospital medicine, EDs, acute paediatrics, intensive care and anaesthesia. All PACC content is made available free online (https://vimeo.com/aplsaustralia). The PAC conference 2015 was held at Coogee, Sydney. We provide a summary of some of the presentations.