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1.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-38003463
2.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33813272
3.
Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate.
PLoS Pathog
; 11(6): e1004995, 2015 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-26098424
4.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-36625640
5.
Regulation of gene transcription by thyroid hormone receptor ß agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
PLoS One
; 15(12): e0240338, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-33306682
6.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
J Med Chem
; 63(18): 10380-10395, 2020 09 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-32816483
7.
HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives.
Bioorg Med Chem Lett
; 19(15): 4476-9, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19502055
8.
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives.
Bioorg Med Chem Lett
; 19(15): 4480-3, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19500983
9.
Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
J Med Chem
; 62(9): 4555-4570, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30951311
10.
Preclinical characteristics of the hepatitis C virus NS3/4A protease inhibitor ITMN-191 (R7227).
Antimicrob Agents Chemother
; 52(12): 4432-41, 2008 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-18824605
11.
Synthesis and anti-HIV activity of cyclic pyrimidine phosphonomethoxy nucleosides and their prodrugs: a comparison of phosphonates and corresponding nucleosides.
Nucleosides Nucleotides Nucleic Acids
; 26(6-7): 573-7, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-18066858
12.
Activation Pathway of a Nucleoside Analog Inhibiting Respiratory Syncytial Virus Polymerase.
ACS Chem Biol
; 12(1): 83-91, 2017 01 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-28103684
13.
Gatekeepers in the ribosomal protein s6: thermodynamics, kinetics, and folding pathways revealed by a minimalist protein model.
J Mol Biol
; 340(3): 571-85, 2004 Jul 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-15210355
14.
Development of a Hyperglycosylated IFN Alfacon-1 (CIFN): Toward Bimonthly or Monthly Dosing for Antiviral Therapies.
J Interferon Cytokine Res
; 35(8): 621-33, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-25866898
15.
Computer simulations of a two-dimensional system with competing interactions.
Phys Rev E Stat Nonlin Soft Matter Phys
; 65(3 Pt 2B): 036706, 2002 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-11909306
16.
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs.
Bioorg Med Chem
; 15(16): 5519-28, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17562366
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