RESUMEN
We evaluated the contribution of Tc-99m methylene diphosphonate (MDP) scintimammography (MDP-SMM) to the diagnosis of breast cancer in 96 patients with 109 (52 palpable, 57 nonpalpable) breast lesions and compared them with mammography. Mammographic classification of the lesions were done as probably malignant (29), indeterminate (29) and probably benign (51). There were 23 malignant and 86 benign lesions. MDP-SMM successfully detected 16 of 23 (70%) breast cancers. Twelve of the 13 palpable and 4 of the 10 nonpalpable cancers showed Tc-99m MDP accumulation. Eight of the 86 (9%) benign breast lesions showed Tc-99m MDP accumulation (false positives). In the mammographically indeterminate group, MDP-SMM changed 22 of the 24 false positives into true negatives and showed 2 false negatives. In the 35 lesions detected in dense breasts, 10 of the 13 false positives were changed into true negatives and showed 1 false negative. As a conclusion, combined use of MDP-SMM with mammography seems to be useful in cases with mammographically indeterminate breast lesions and dense breasts and may help to preclude unnecessary breast biopsies.
Asunto(s)
Neoplasias de la Mama/diagnóstico , Mamografía , Medronato de Tecnecio Tc 99m , Adulto , Anciano , Neoplasias de la Mama/diagnóstico por imagen , Femenino , Fibroadenoma/diagnóstico , Humanos , Persona de Mediana Edad , Palpación , Cintigrafía , Sensibilidad y EspecificidadRESUMEN
Although mucocutaneous sites are the most frequently encountered sites of involvement, Kaposi Sarcoma (KS) may also occasionally involve the breast and the skeletal, endocrine, urinary and nervous systems.. Various imaging modalities may be used to delineate the extent of the disease by detecting unexpected sites of involvement. Herein, we report a case of classical type KS, in whom staging with (18)F-FDG PET/CT imaging disclosed widespread disease and unexpected findings of bone and salivary gland involvement.
Asunto(s)
Fluorodesoxiglucosa F18 , Seronegatividad para VIH , Imagen Multimodal , Tomografía de Emisión de Positrones , Radiofármacos , Sarcoma de Kaposi/diagnóstico por imagen , Neoplasias Cutáneas/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Anciano de 80 o más Años , Humanos , MasculinoRESUMEN
We report the clinical value of FDG PET/CT imaging in a 57-year-old woman who was diagnosed with uterine leimyosarcoma 6 years ago. In a staging procedure, whole body FDG PET/CT discloses the presence of both local recurrence and remote metastases at widespread musculocutaneous sites, liver and femur. With its advantage of scanning the whole body in a single procedure, we propose the use of PET/CT imaging for the evaluation of patients with uterine leimyosarcomas, a tumor with a propensity for widespread hematogenous spread to unusual sites.
Asunto(s)
Fluorodesoxiglucosa F18 , Leiomiosarcoma/diagnóstico , Leiomiosarcoma/secundario , Imagen Multimodal , Neoplasias de los Músculos/diagnóstico , Neoplasias de los Músculos/secundario , Radiofármacos , Neoplasias Cutáneas/diagnóstico , Neoplasias Cutáneas/secundario , Neoplasias Uterinas/patología , Femenino , Humanos , Persona de Mediana Edad , Músculo Esquelético , Tomografía de Emisión de Positrones , Tomografía Computarizada por Rayos XRESUMEN
INTRODUCTION: (18)F-FDG PET has been regarded as a limited value in urooncology due to urinary excretion of the tracer. The purpose of this retrospective study was to investigate the clinical value of dual-phase FDG PET/CT with forced diuresis protocol (iv furosemide-voiding and oral hydration) in invasive or high grade bladder cancer. METHODS: Fifty-one patients were included in this study. All patients underwent standard staging procedures and dual-phase FDG PET/CT before planned therapy. PET/CT findings before and after furosemide were compared with each other for pelvic region. Dual phase PET/CT findings were also compared with the results of prior imaging studies and all findings were correlated with final diagnosis (histopathology or clinical follow-up for at least 12 months). RESULTS: Intravesical FDG activity significantly decreased in 90% of the patients with forced diuresis protocol. Eighty eight percent of the bladder findings and 20% of the local lymph node metastases, and other pelvic findings (local invasion and second primary malignancy of prostate) were detected only by the additional pelvic PET/CT images. As a result, dual phase PET/CT changed the staging and/or the therapy strategy in 16 patients (31%). CONCLUSION: Dual phase FDG PET/CT contributes staging and decision of therapy strategy by detecting local disease and pelvic metastases with high accuracy when combined with forced diuresis protocol. Thus, we recommend dual phase imaging method with forced diuresis protocol in FDG PET/CT for bladder cancer and all other urogenital system malignities.