RESUMEN
The presence of a general practitioner (GP) at the hospital emergency ward is a first attempt to answer a society phenomenon, challenging the hospital manager, but related to a more complex and extensive problem. New habits, due to various reasons, eventually move an ever growing proportion of patients from the community GP towards the hospital. The relationships between the patient and the practitioner are collapsing down like those between family members especially in towns. How can we resolve such an evolution politically? To have the city GP inside the hospital as it is already the case in big US cities? or, to favor the central role of the community general practitioner in the medical management of the patients, but in opposition to the present course of events? The first solution would be more expensive than the second one.
Asunto(s)
Servicio de Urgencia en Hospital/organización & administración , Medicina Familiar y Comunitaria/organización & administración , Rol del Médico , Actitud Frente a la Salud , Bélgica , Medicina Comunitaria/organización & administración , Humanos , Relaciones Interprofesionales , Cuerpo Médico de Hospitales/psicología , Evaluación de Necesidades , Innovación Organizacional , Relaciones Médico-PacienteAsunto(s)
Algoritmos , Diagnóstico por Imagen , Hipertensión/diagnóstico , Árboles de Decisión , Diagnóstico por Imagen/métodos , Humanos , Imagen por Resonancia Magnética , Obstrucción de la Arteria Renal/diagnóstico , Insuficiencia Renal/diagnóstico , Tomografía Computarizada por Rayos X , Ultrasonografía DopplerRESUMEN
Three quaternary alkaloids have been isolated from root barks of STRYCHNOS USAMBARENSIS Gilg from Rwanda: malindine, isomalindine and Nb-methyl-antirhine. The structure elucidation and the stereochemistry of the new isomalindine has been proposed based on its spectral data and their comparison with those of malindine, its isomer.
RESUMEN
Strychnoxanthine, an anhydronium base, was isolated from root barks of STRYCHNOS GOSSWEILERI, a few years ago. The structure of this new indole alkaloid is now established by spectral analysis, especially by (1)H NMR at 360 MHz.
RESUMEN
The structure and the stereochemistry of afrocurarine (a new unsymmetrical bisindole alkaloid) previously isolated from S. USAMBARENSIS Gilg. are established especially from (1)H-NMR spectroscopic data. The separation of quaternary alkaloids has always been very tedious. Ion-pair reversed-phase column chromatography applied to the purification of afrocurarine is proved very useful and seems to be a suitable technique in quaternary alkaloid research.
RESUMEN
Cholinesterase (EC 3.1.1.8) for intravenous use has been obtained from fraction IV, a by-product of ehtanol fractionation. A four-step procedure has been developed associating precipitation by Rivanol and PEG 4000 with chromatography on DEAE-cellulose. The yield corresponds to 30--35% of the activity found in fraction IV. Vials containing 5000 U of CHE stabilized by 2.5% albumin have been prepared. The pyrogen-free product is well tolerated in the human.
Asunto(s)
Colinesterasas/sangre , Plasma , Centrifugación , Fraccionamiento Químico , Cromatografía DEAE-Celulosa , Cromatografía por Intercambio Iónico , Etacridina/farmacología , Etanol/farmacología , Humanos , Polietilenglicoles/farmacologíaRESUMEN
The prothombin complex is adsorbed from plasma or cryoconcentrate supernatant onto DEAE-sephadex A50. The adsorbent is washed several times with 0.21 M NaCl. The first washing proved to be a new subfraction of routine fractionation suitable as starting material for the purification of several proteins such as C1-inactivator, N-carboxypeptidase, ceruloplasmin and kallikrein.
Asunto(s)
Proteínas Sanguíneas/aislamiento & purificación , Adsorción , Fraccionamiento Químico/métodos , Cromatografía por Intercambio Iónico , Humanos , ProtrombinaRESUMEN
Two quaternary alkaloids have been isolated from the root barks of Strychnos variabilis collected in Zaïre. The structure of these alkaloids (mavacurine and fluorocurine) could be deduced from spectral data: UV, MS, IR and (1)H NMR. Moreover, the stereochemistry could be assigned by (1)H NMR at 360 MHz.
RESUMEN
The 1H (at 300 MHz) and 13C nuclear magnetic resonance spectra of virginiamycins S and S4 and vernamycin Balpha have been unravelled and analyzed. Together with model building and theoretical considerations, this allows the detailed description of their solution conformations. The depside bond can rotate and gives to the backbone some conformational mobility. The orientation of the depsicarbonyl bond depends on the surrounding. Apparent discrepancies between the different methods that are applicable for the disclosure of the nature of peptide H-bonding, have found a rational explanation.