[The preparation of an IgG diagnostic agent based on stained polyacrolein latexes for use in the latex agglutination reaction]. / Prigotovlenie IgG-diagnostikuma na osnove okrashennykh poliakroleinovykh lateksov dlia primeneniia v reaktsii lateksnoi aggliutinatsii.

IgG diagnosticum for measuring the concentration of 131I-labeled IgG antibodies to enteric antigen beta 1MA by the latex agglutination inhibition (LAI) test has been prepared on the basis of polyacrolein latexes. A method for the titration of anti-IgG antibodies with the use of the above diagnosticum has been developed, based on the late, agglutination (LA) test. The optimum conditions for the microtitration variant of the LA and LAI tests have been defined. High sensitivity, specificity and simplicity of analysis with the use of latex IgG diagnosticum have been demonstrated. The newly developed methods have been successfully used in laboratory trials of a new diagnostic radiopharmaceuticals for the assay of 131I-labeled antibodies in this preparation and for the detection of side effects of immunization on the recipients.

[Hypoglycemia and epilepsy syndrome in diabetes mellitus in children]. / Gipoglikemiia i épilepticheskii sindrom pri sakharnom diabete u detei.

Eight children suffering from diabetes mellitus and epilepsia were followed up. Emphasis is laid on the necessity of measuring glycemia in diabetes mellitus patients during convulsive attacks as well as on the importance of early diagnosis of epilepsia to institute multimodality treatment.

[Diagnostic value of detection of blood levels of lactate, pyruvate and 2,3-diphosphoglycerate in children with diabetes mellitus]. / Diagnosticheskoe znachenie opredeleniia urovnia laktata, piruvata i 2,3-difosfoglitserata v krovi pri sakharnom diabete u detei.

Measurements were made of lactate, pyruvate and 2,3-diphosphoglycerate in 69 children admitted to the hospital in a state of diabetic ketoacidosis of different intensity. Depending on the intensity of metabolic abnormalities, the content of lactate and pyruvate was found to be increased, whereas that of 2,3-diphosphoglycerate to be lowered. Measurements of the content of lactate and the lactate/pyruvate ratio enables carrying out differential diagnosis between the ketoacidotic and lactacidotic varieties of diabetic coma.

[Insulin requirements of patients with initial manifestations and decompensation of diabetes mellitus]. / Insulinovaia potrebnost' pri pervoi manifestatsii i dekompensatsii sakharnogo diabeta.

Altogether 100 children suffering from insulin-dependent diabetes mellitus were examined. Analysis of insulin requirement was performed in children with the first disease manifestation and in those with varying disease standing with regard to the type of insulin preparations used. According to the clinical observations, mono-component insulin preparations turned out absolutely superior in the attainment of diabetic process compensation in children with a comparatively low insulin requirement in the course of the treatment of the first disease manifestation and insulin requirement appreciably rose with the increase of the disease standing or superaddition of intercurrent diseases.