[Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study]. / Efecto hipotensor de la pilocarpina en ojos tratados crónicamente con latanoprost; un estudio piloto.

PURPOSE: To study the ocular hypotensive effect of pilocarpine in latanoprost treated eyes. METHODS: We measured the IOP in both eyes of 25 patients, before and after instillation of pilocarpine 2% in one eye, and placebo in the other. This is a prospective, double blind, placebo-controlled study. RESULTS: We found that the mean change in IOP of the study eyes was +0.4 on average (range of change from -3 to +5 mmHg), compared with the control, placebo treated eyes (p=0.5). CONCLUSIONS: The acute administration of pilocarpine in Latanoprost treated eyes seems to have a paradoxical effect on IOP, as the IOP may increase or decrease.