RESUMEN
In this investigation, cobalt ferrite nanoparticles (CFO NPs) were synthesized using a hydrothermal method. Then, silver nanoparticles (Ag NPs) were decorated on CFO NPs to form Ag/CFO NPs using jasmine extract as a reducing agent of Ag+ ions. The properties of Ag/CFO NPs were characterized by X-ray powder diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, Fourier-transform infrared spectroscopy, vibrating sample magnetometry, and catalytic tests in non-radiation conditions. The catalytic results indicated that the Ag/CFO NPs could activate peroxymonosulfate to generate sulfate radicals for the decomposition of different dyes such as methylene blue, methyl orange, and rhodamine B. For the Ag/CFO sample, Ag NPs validated the roles in dye adsorption, reduction of 4-nitrophenol, and improvement of antibacterial behavior. The growth inhibition activity of Ag/CFO NPs was observed against Pseudomonas aeruginosa (18.18 ± 2.48 mm) and Staphylococcus aureus (10.14 ± 0.72 mm). Furthermore, Ag/CFO NPs displayed good reusability after three consecutive runs. Therefore, Ag/CFO material is shown to be a potential multifunctional catalyst in wastewater treatment.
RESUMEN
Biodegradable periodic mesoporous organosilica (BPMO) nanoparticles have emerged as a promising type of nanocarrier for drug delivery, given the biodegradable feature is advantageous for clinical translation. In this paper, we report synthesis and characterization of daunorubicin (DNR) loaded BPMO. DNR was loaded onto rhodamine B-labeled BPMO that contain tetrasulfide bonds. Tumor spheroids and chicken egg tumor models were used to characterize the activity in biological settings. In the first experiment we examined the uptake of BPMO into tumor spheroids prepared from ovarian cancer cells. BPMO were efficiently taken up into tumor spheroids and inhibited their growth. In the chicken egg tumor model, intravenous injection of DNR-loaded BPMO led to the elimination of ovarian tumor. Lack of adverse effect on organs such as lung appears to be due to excellent tumor accumulation of BPMO. Thus, DNR-loaded BPMO represents a promising nanodrug compared with free DNR currently used in cancer therapy. OK.