[Viral hepatitis in patients over 60 years of age. Clinical, etiologic and developmental aspects]. / Les hépatites virales après 60 ans. Aspects cliniques, étiologiques et évolutifs (78 cas).

The authors report a retrospective study of 78 cases of acute viral hepatitis observed from 1971 to 1985 in patients over 60. Viral hepatitis involved males as often as females. A, B, delta and non-A, non-B viruses were responsible for 11.5, 23.1, 5.1 and 60.3 p. cent of cases, respectively. From 1975 on, the frequency of non-A non-B viral hepatitis has reached 85 p. cent while blood transfusions appeared as the most important route of transmission. Outcome was severe in 10.3 p. cent of cases. Early in the course of disease, the risk of progression to cirrhosis was obvious and concerned 12 patients (1 out of 18 with B hepatitis, 3 out of 4 with D hepatitis, 8 out of 47 non-A non-B hepatitis). The long term prognosis (from three to five years) was not as poor as stated in previous studies.

[Simultaneous hepatic cholangiocarcinoma and bone fibrosarcoma 45 years after ingestion of Thorotrast]. / Cholangiocarcinome hépatique et fibrosarcome osseux synchrones 45 ans après injection de Thorotrast.

This case of a 63 year old man reports the simultaneous development of hepatic cholangiocarcinoma and fibrosarcoma of the sacrum 45 years after the systemic injection of Thorotrast. The characteristic radiologic aspect was an important criteria for diagnosis. Biopsies have confirmed the histology of both tumors. We describe the way to thorotrastosis diagnosis and characteristic malignant tumors, especially cholangiocarcinoma, induced by Thorotrast.

[Hepatic amebiasis: study of 152 cases]. / L'amibiase hépatique: étude de 152 observations.

The purpose of this study was to describe and analyse retrospectively the clinical, serological, anatomical and evolutive features of 152 cases of hepatic amebiasis in young adults, treated and followed up in France from 1969 to 1983. The disease was revealed 3 times out of 4 by tender hepatomegaly with fever, but only in 6 cases by complications. Serological tests (immunofluorescence or hemagglutination) were always positive for amebiasis, whereas Entamoeba histolytica was absent from stools in 96.7 p. 100 of the cases. Hepatic amebiasis always caused a hepatic abscess: in these cases, the superiority of ultrasonography over all other diagnostic methods was confirmed, especially concerning the detection of multiple abscesses (47 p. 100). Complete recovery was obtained by medical treatment in 117 cases, either alone (98 cases), or combined with needle aspiration (19 cases). Nitro-imidazoles are the simplest treatment, but nevertheless in 5 cases they were not effective. These patients were then treated with dehydroemetine, associated in 2 cases with surgery. Four patients relapsed at mid or long-term after apparent recovery, in the absence of any obvious reinfection. A significant correlation between the course of the treated disease and the size and number of abscesses was demonstrated: it was possible to define a group characterized by a slow and/or complicated course (with single abscess of the right lobe whose diameter is equal to or greater than 10 cm, or multiple abscesses). The pathogenesis of hepatic amebiasis is not yet fully understood.

[Yellow nail syndrome with chylous effusions]. / Syndrome des ongles jaunes avec épanchements chyleux.

Yellow nail syndrome is characterized by a yellow discolouration of the nails associated with idiopathic lymphoedema and pleuropulmonary manifestations. Pleural effusions are usually of the exudate type with a normal lipid content. The case reported here of a 74-year old man who had yellow nails together with chylothorax and chylous ascites provides an opportunity to discuss the origin of these rare effusions which, like the syndrome itself, were most probably due to primary abnormalities of the lymphatic system.

[Sarcoidosis and sarcoid reaction associated with Hodgkin's disease]. / Sarcoïdose et réaction sarcoïdosique associées à la maladie de Hodgkin.

The authors report a case of Hodgkin's disease associated with pulmonary and mediastinal sarcoidosis, and they recall the frequency of sarcoid reactions in lymphoma, notably in Hodgkin's disease. The Hodgkin's disease-sarcoidosis association is much less common and sometimes raises difficult diagnostic problems. The physiopathological mechanisms that are possibly involved are analyzed.

[Genetic hemochromatosis disclosed by isolated increase of aminotransferases]. / Hémochromatose génétique révélée par une élévation isolée des aminotransférases.

The authors report five cases of genetic hemochromatosis in asymptomatic patients with elevated serum aminotransferases. They precise the interest of liver biopsy and hepatic iron concentration especially of hepatic iron index.

[Value of video-assisted thoracic surgery in internal medicine. Apropos of 7 cases]. / Intérêt de la chirurgie thoracique vidéoassistée en médecine interne. A propos de sept observations.

Since a few years, the medical thoracoscopy has already been used specially for the diagnostic and therapeutic taking up of the pleural pathology. Behind it, the video-assisted thoracic surgery has been improved since 1990. As a surgical technology, it proved its interest refering to the classical thoracotomy by lessening operative morbidity and mortality. The authors discuss its main indications about seven cases, recruted in the internal medicine service and operated in the thoracic surgery service of the Val-de-Grâce hospital. Some of these indications are now admited by most of the authors: 1) diagnostic aims: pulmonary biopsy in case of interstitial pathology, of pulmonary peripheral under-pleural nodule and sometimes of solid tumors of the mediastinum, specially of some lymph-nodes. 2) Therapeutic aims: the spontaneous pneumothorax treatment of the adult remains the most classical indication; the thoracic sympathectomy, the creation of pleuropericardial windows and the resection of benign tumors of the mediastinum are now well acknowledged indications.

[Acute myelitis after vaccination against hepatitis B]. / Myélite aiguë après vaccination contre l'hépatite B.

A 56-year old man was hospitalized for spasmodic paraparesis with sphincter disorders. After exclusion of spinal cord compression and all other inflammatory, infectious or neoplastic causes, the possibility of a connexion with an hepatitis B vaccination performed with a recumbent vaccine three weeks before the neurological disorders appeared was considered. The pathogenesis of such a myelitis remains uncertain. It is based on the possible reactivation of a dormant virus or a crossed antigenic reaction between a protein of the vaccine and the nervous system. The course of the disease is usually favourable. The frequency of this complication would be more accurately determined if all neurological manifestations occurring after hepatitis B vaccination were reported.

[Acute evolution as a rare complication of a chronic calcified pancreatitis. Report of a Malagasy case (author's transl)]. / Complication aiguë rare d'une pancréatite calcifiante chronique (à propos d'un cas observé à Dakar).

Report of an acute inflammatory syndrome of the right side of the belly with fever, polyleucocytosis and diabetes in a 35 years old patient with chronic calcified pancreatitis. The right colon was moved forward by an important retroperitoneal infiltration and the pathology demonstrated a cytosteatonecrosis. The post-operative period was disturbed by hyperamylasemia, hyperamylasuria and an external pancreatic fistule.

[Gout and hyperuricemia in Tananarive (Madagascar) (author's transl)]. / Goutte et hyperuricémie à Tananarive.

Review of 41 cases observed in "Girard et Robic hospital", Tananarive (35 cases of plain articular gout either acute or chronic, and 6 cases of latent hyperuricemia).--Gout and hyperuricemia are frequently observed within Malagasy high-lands Merina population.--Women and even, in exceptional cases, children may be affected. A responsible hereditary factor is probably associated with the side effects of food habits (diet rich in rice, local vegetables, zebu meat and pork; beverages are not abundant).

[Cerebral malaria with renal insufficiency in a 5 months pregnant woman. The use of prostaglandines for delivery (author's transl)]. / Accès pernicieux palustre et insuffisance rénale chez une femme enceinte de 5 mois utilisation des prostaglandines pour la délivrance.

Report of a typical case of cerebral malaria with coma during 3 days, pneumopathy and renal insufficiency with failure of concentration. The delivery of a dead foetus has been started by prostaglandines.

[Thyphoid fever in Tananarive (Madagascar): a review of 20o cases (author's transl)]. / La fièvre Typhoïde à Tananarive: à propos de 200 observations.

A clinical and biological study of 200 cases in Tananarive. The conventional clinical form is still frequent because patients have no immunity and report too late to the hospital. The main complications concern the heart and the digestive tract. Hemoculture is the main clue for the diagnosis. Biochemical and specially enzymatic unconventional data whichs have been recently reported are frequently observed. No resistance to chloramphenicol has yet been detected in Tananarive.

[Shigellosis in Tananarive (Madagascar) I - Epidemiologic and clinic features (author's transl)]. / Les shigelloses à Tananarive (Madagascar). I. - Aspects epidémiologiques et cliniques.

Reviewing 67 cases of human adult shigellosis observed in Madagascar, the authors emphasize some epidemiologic and clinic features : high frequency during rainy season, usual dysenteriform aspect or diarrhoeas with fever, hemorragic forms, severity according to anterior state of colon and rectum, severity if cases associated with amoebiasis or schistosomiasis (Schistosoma mansoni).

[Shigellosis in Tananarive (Madagascar). II : Bacteriologic and therapeutic features (author's transl)]. / Les shigelloses à Tananarive (Madagascar). II. - Aspects bactériologiques et thérapeutiques.

In acute dysenteries or diarrhoeas shigellae are the bacterial organisms which are the most frequently isolated from coprocultures. The most frequent sub-group is sub-group B (S. flexniri). In vitro, shigellae are sensible to all antibiotics but often resistant to sulfamids. Treatment is not difficult.

[Disseminated Histoplasma duboisii histoplasmosis in a female inhabitant of the Ivory Coast]. / Histoplasmose disséminée à Histoplasma duboisii chez une Ivoirienne.

The authors describe a disseminated multivisceral form of african histoplasmosis due to H. duboisii in a 45 years old black woman. Clinical examination shows characteristic lesions of skin, bones and lymph glands. Lymphography reveals lesions of deep lymph glands and laparascopy lesions of liver and spleen. First untimely stopped, treatment was started again with ketoconazole. 20 months later, the course of the disease is, as for as we can appreciate it, favourable.

[Distribution of HBs antigen in Tananarive (author's transl)]. / Répartition de l'antigène HBs à Tananarive.

This survey has been conducted among blood donors and patients with hepatitis, cirrhosis, liver carcinomas and various causes of liver dysfunction or enlargement. The frequency is 5,4 p. 100 among blood donors and 50 p. 100 among cases of hepatitis.

[Distribution of HBs antigen in Tananarive (author's transl)]. / Répartition de l'antigène HBs a Tananarive.

This survey has been conducted among blood donors and patients with hepatitis, cirrhosis, liver carcinomas and various causes of liver dysfunction or enlargement. The frequency is 5,4 p. 100 among blood donors and 50 p. 100 among cases of hepatitis.

[Hepatic amebiasis in France. Apropos of 152 case reports]. / L'amibiase hépatique en France. A propos de 152 observations.

The authors report upon 152 cases of hepatic amebiasis (H.A.) observed in France between 1969 and 1983, among young european men (average age 29,2) who were hospitalised in the initial phase of their illness. H.A. was clinically revealed through a painful and febrile hepatomegaly in 3/4 cases and in 6 cases through complications. No chronic form was observed. The amebic serology (I.F.I. and/or H.A.P.) was always positive. The research of an intestinal portage of the parasite was generally negative. The hepatic functions were impaired in the third of the cases. Whichever technique was employed, the anatomic diagnosis has always been made in a phase of intra hepatic collection. The superiority of echotomography over other methods is confirmed (especially for diagnosis of multiple abscess: 47% of success). All patients recovered, most frequently through medical treatment (117 cases). The nitro-imidazoles (1,5 to 2 g per day during 7 to 14 days) remain the prefered treatment, but they are responsible for 5 failures which were overcome by emetine. On the other hand, 4 patients had, after being cured, showed middle and long term relapses without patient recontamination. The evolution of the treated H.A. is significantly correlated to the importance and/or the multiplicity of the liver collection: the voluminous abscess of the right lobe being the most potentially dangerous. The pathogenesis of the H.A. remains imperfectly known. The different clinical aspects which have been found, depend upon the preexistant immunity of the patient and could also be equally associated with a pathology of complex immunity systems.