[Role of tissue glycolysis in combined exposure to hypercapnia, hypoxia and hypothermia]. / Znachenie glikoliza v tkaniakh pri sochetannom vozdeistvii giperkapnii, gipoksii i gipotermii.

The amount of metabolites of the glycolytic way of carbohydrates transformation and the enzymatic activity were studied in the tissues of brain, myocardium, liver, skeletal muscles, and the blood serum of rats subjected to cooling in conditions of gradually increasing concentrations of CO2 and decreasing concentrations of O2. Single as well as repeated actions of these factors entailed changes of the substrates under study and of some enzymatic activity which revealed a moderate intensification of the glycolysis within the general rearrangement of metabolism during adaptation to sharp hypoxia under the above conditions.

[The role of occupational medicine in the development of current and future legal documents on women's work safety and women's health]. / Rol' meditsiny truda v razrabotke deistvuiushchikh i perspektivnykh zakonodatel'nykh dokumentov po okhrane truda i zdorov'ia zhenshchin.

The article covers legal documents of general and specific measures for women's work safety and health care. Legal basis for work safety and health care in women of childbearing age in this country corresponds with international legal norms. Preservation of social and biologic prosperity for women in this country should be guaranteed by "On protection of maternity" law including medical, social, economic and legal measures.

[Occupational hazards as risk factors of perinatal pathology]. / Professional'nye vrednosti kak faktor riska perinatal'noi patologii.

Occupational hazards play the leading role among the factors responsible for perinatal disease, increased morbidity and mortality of neonates and infants of the first year of life. These factors are deleterious to the female organism both prior to and during pregnancy, they may exert an unfavourable effect on the fetus, and impair the general health status of future mothers by affecting the functioning of separate organs and body systems, triggering metabolic disorders, and reducing body defence. Studies conducted by experts in labour hygiene, obstetricians-gynecologists, and pediatricians yielded results that formed the basis for prevention planning aimed at health promotion effect.

[Age and the effect of proserine on the contractile response of the rectum and inhibition of its cholinesterase in rats]. / Vozrastnye osobennosti sokratitel'noi reaktsii priamoi kishki krys i ingibirovaniia ee kholinésterazy pod vliianiem prozerina.

The motor reaction of the rectum strips in rats of 4 age groups and inhibition of its cholinesterase with proserine were studied. To low proserine concentrations (1.10(-8)-1.10(-6) M) the intestine of 1-week old rattlings was found to react only by relaxation, contractions appearing only with a concentration of 1.10(-5) M. The maximal contractile reaction of the intestine to proserine was found to occur in 4-week old rattlings. The cholinesterase activity in the rectum of 1-week old rattlings is lower, and in the 4-week old ones higher than in adult animals. The inhibition of cholinesterase occurs in all the age groups from a minimal tested proserine concentration (1.10(10) M), gaining in strength parallel with increasing concentration. The maximum inhibition of the enzyme was found to occur in the 4-week old rattlings.

[Krebs cycle in tissue of rats subjected to combined effect of hypercapnia, hypoxia and cooling]. / Tsiki krebsa v takniakh krys, podvergnutykh sochetannomy vozdeistviiu giperkapnii, gipoksii i okhlazhdeniia

The content of the Krebs cycle substrates and activity of dehydrogenases corresponding to them were studied in the brain and myocardium tissues of the non-linear male rats adapted to acute hypoxia under conditions of the altered gas medium. The content of malate and succinic acid was studied in the liver and skeletal muscles only. In the brain the total activity of malate dehydrogenase (MDH, EC 1.1.1.37, 1.1.1.39) alpha-ketoglutarate dehydrogenase (KDH, EC 1.2.4.2) pyruvate dehydrogenase (PDH, EC 1.2.4.1) and isocitrate dehydrogenase (ICDH, EC 1.1.1.41-42) is shown to be decreased and kept to be lowered in all the periods of the study. No essential shifts in the activity of these dehydrogenases were found in the myocardium. The activity of succinate dehydrogenase (SDH, EC 1.3.99.1) in both tissues lowers 48 h after the effect of the mentioned factors. Simultaneously the greatest changes in the level of the substrates were observed in the myocardium, in the brain they were less developed. In the liver the content of malate increases without pronounced changes in the amount of succinic acid and in the skeletal muscles the level of malate and succinic acid lowers.

[Changes in lipid and carbohydrate metabolism in rat tissues under combined effect of hypercapnia, hypoxia and cooling]. / Izmeneniia Zhirovogo i uglevodnogo obmenov v tkaniakh krys pri sochetannom vozdeistvii giperkapniei, gipoksiei i okhlazhdeniem.

The cooling of rats under conditions of hypercapnia and hypoxia during the first 15 minutes increases the contents of free fatty acids, acetoacetate and beta-oxybutyrate in the tissues of the brain, myocardium, liver, skeletal muscles and blood and decreases them by the end of the effect (120 min later) down to the initial values, in the liver and skeletal muscles tissues the content of the mentioned intermediates falls lower the initial values. In the carbohydrate metabolism the amount of phosphoenolpyruvate 15 and 120 min after the action beginning and the amount of malate in the myocardium and brain at the end of the experiment increase to a different extent; the content of lactate rises only in the brain 30 and 120 min after the beginning of cooling. In the rat venous blood the value of pCO2 increases up to 71.8+/-6.0 mm Hg, the total content of CO2 rises, the values of the standard bicarbonates decrease and the pH value drops sharply down to 6.98+/-0.03. It is suggested that one of the main reasons of such changes in metabolism is development of hypercapnia state and acidosis and the resulted increase in intensity of the carboxylation processes in the tissues.

[Organization of in- and outpatient treatment of new cases of destructive pulmonary tuberculosis]. / Organizatsiia statsionarno-ambulatornogo lecheniia vpervye vyiavlennykh bol'nykh destruktivnym tuberkulezom legkikh.

A system of in- and outpatient treatment of the first detected patients with destructive pulmonary tuberculosis is proposed. The use of various types of intravenous intermittent chemotherapy in patients with focal, infiltrative, and disseminated tuberculosis provides a high efficiency in the inpatient period (the mean time of sputum negativation is 1.6 months, that of destruction closure is 3.1 months) and early (in 2 - 3 months) transfer of these patients to outpatient additional treatment by continuing etiotropic therapy that has turned out to be effective in hospital.