[Evidence Register Green List Prevention: Analysis of the listed effectiveness-tested programmes]. / Evidenzregister Grüne Liste Prävention ­ Analyse der gelisteten wirksamkeitsgeprüften Programme.

BACKGROUND: In the areas of prevention and health promotion, there is a large number of measures for children and adolescents. One way of facilitating evidence-based action for those involved in these taks is by making available online evidence registers with customised, effectiveness-tested measures. The Green List Prevention is such a register and offers an overview of evidence-based programmes in Germany, currently with a focus on psychosocial health. OBJECTIVE: The aims of this study were (a) to analyse the characteristics of the available and evaluated programmes on the psychosocial health of children and adolescents, (b) to identify priorities and underrepresented areas of the Green List Prevention and (c) to optimise the search functions of the register. METHOD: The characteristic features were recorded on the basis of the existing upper categories of the register entries which were differentiated into subcategories in an inductive procedure by at least two persons. In addition, deductive categories were added for relevant aspects concerning content and implementation. The upper and lower categories formed were operationalized with characteristic values. All entries were analyzed by using a data sheet and were descriptively evaluated. RESULTS: The 102 programmes listed (as of 2/2024) addressed not only the primary target group of children and youth, but also secondary target groups (mainly teachers and guardians). Social and life skills programmes as well as trainings for guardians represented a focus. Behavioral prevention programmes on the topics of violence (including bullying) (63.7%), addiction (46.1%) and/or mental health (35.3%) were frequently represented, whereas nutrition and/or physical activity (4.9%) were hardly represented. Most of the programmes (88.2%) could be assigned to the eligibility criteria of the statutory health insurers (§20a SGB V). Potentials digital implementation forms and further implementation aspects were identified. CONCLUSION: The Green List Prevention bundles a large number of different measures and that there is potential for expansion. Processing knowledge about effective measures in a user-friendly manner can be optimised through expanded search functions, so that resource-conserving, evidence-based action can be facilitated.

[Evidence-based prevention for child and adolescent mental health: the "Communities That Care" (CTC) approach for Germany]. / Evidenzbasierte Prävention für die psychische Gesundheit von Kindern und Jugendlichen: Der Ansatz "Communities That Care" (CTC) für Deutschland.

Intersectoral collaboration, evidence base, and sustainable implementation are central challenges in community health promotion. The international prevention system Communities That Care (CTC) addresses these challenges. CTC aims to prevent alcohol and drug abuse, violence, delinquency, school dropout, and depressive symptoms among adolescents with a systemic multi-level strategy. The evidence-based and cost-effective prevention system developed in the USA was adapted to Germany; at present, a replication study evaluates the cost-effectiveness.CTC is based on empirical theory and follows a five-phase process model. Essential for acceptance and evidence-based implementation is the formation of an intersectoral coalition, whose members receive advisory support and training over several years. The actors are empowered to use a system change model at the municipal level and to implement it in the long term. The aim is to select evidence-based measures in a data-driven and needs-oriented manner and to implement them in consideration of the local contextual conditions in order to reduce risk factors, promote protective factors, and thus improve the health of adolescents. Validated instruments such as the CTC Children and Youth Survey and a registry with evidence-based prevention programs ("Grüne Liste Prävention") support the process.As a systemic intervention, CTC integrates existing local structures and agencies and involves them in the entire process through new decision-making and development bodies. In this way, the potential in the municipality is used and, as much as possible, resources are bundled, strengths are developed, and transparency is created.

[Family as a Health-Maintaining Resource for Late Repatriates? A Qualitative Study of Health Attitudes in Old Age]. / Familie als gesundheitserhaltende Ressource bei Spätaussiedler/innen?! Eine qualitative Studie zu Gesundheitsvorstellungen im Alter.

BACKGROUND: In the context of demographic changes in Germany, it can be observed that the number of older people among the second largest migrant group - the so-called late repatriates - is on the rise. The health and utilisation behaviour of preventive measures by this group differs from that of the German population or people with a different migration background. An essential prerequisite for the design of target group-specific prevention measures is the knowledge of health expectations of the late repatriates. GOAL OF THE STUDY: The goal of this study was to show the importance of the family and the predominant role models of late repatriates in health attitudes. METHOD: Guided interviews were conducted with 13 late repatriates in Russian and evaluated using the documentary method. RESULTS: The family and the care for (grand-)children was a central element of the preservation of health of the respondents. The traditional role models brought from the Soviet Union were partly preserved and partly (regardless the gender) expanded by the care for the (grand-)children. CONCLUSION: The involvement of (grand-)children has a health-promoting effect on maintaining health in late repatriates and can encourage their use of preventive measures.

[Quality management and development in primary prevention and health promotion: status, challenges, and perspectives]. / Qualitätsmanagement und -entwicklung in der Primärprävention und Gesundheitsförderung: Stand, Herausforderungen und Perspektiven.

In the past three decades, quality development in primary prevention and health promotion have developed significantly. A major contribution to this has been their legal anchoring. The reintroduction of prevention and health promotion in the statutory health insurance and the Prevention Act gave this development an additional boost. The discourse that had already begun in the run-up to this, involving numerous researchers and stakeholders from different fields of prevention and health promotion, contributed to an increased understanding of central aspects of quality development. Comprehensive procedures for quality assurance and development are available for prevention and health promotion. In addition, recommendations for action, checklists, and instruments, for example, have been edited and are easily accessible for all four quality dimensions - planning, structural, process, and outcome quality. Certifications and quality seals for interventions and health promoting institutions are available.However, none of these procedures is used comprehensively and continuously. The fields in prevention and health promotion differ significantly with regard to the implementation of quality assurance. Obstacles are, among other things, insufficient human and financial resources with simultaneous discontinuity and intra-facility quality management systems. There is a need for action to further develop the implementation of quality on site, especially in the community setting, and to better integrate quality assurance into existing structures. Qualification, intensive exchange, and small-scale prevention reporting should promote quality development.

Long-Term Effects of Integrated Strategies of Community Health Promotion on Diabetes Mellitus Mortality: a Natural Policy Experiment Based on Aggregated Longitudinal Secondary Data.

Integrated strategies of community health promotion (ISCHP) are based on intersectoral collaborations using the Health in All Policies approach to address determinants of health. While effects on health determinants have been shown, evidence on the effectiveness of ISCHP on health outcomes is scarce. The aim of this study is to assess the long-term effects of ISCHP on diabetes mellitus mortality (DMM) in German communities. A nonrandomized evaluation based on secondary county-level official data (1998-2016) was performed. In April 2019, 149 communities in Germany with ISCHP out of 401 were identified. Communities with < 5 measurements of DMM, starting before 1999 or after 2015, were excluded. Analyses included 65 communities with ISCHP (IG) and 124 without ISCHP (CG). ISCHP ran for a mean of 5.6 years. Fixed effects (FE) models were used to estimate effects of ISCHP and duration on DMM taking into account the time-varying average age. The FE estimator for DMM is b = - 2.48 (95% CI - 3.45 to - 1.51) for IG vs. CG and b = - 0.30 (95% CI - 0.46 to - 0.14) for ISCHP duration (0-16 years). In the first year of an ISCHP, a reduction of the annual DMM of 0.3 per 100,000 population (1%), and in the 16th year of 4.8 (14%) was achieved. This study provides preliminary evidence of the effectiveness of ISCHP in Germany. Limitations include inaccuracies to classify IG and CG and possible selection bias. Longitudinal county-level data may be an efficient data source to evaluate complex interventions, thereby contributing to further strengthen evidence-based integrated health promotion.

Study protocol: a non-randomised community trial to evaluate the effectiveness of the communities that care prevention system in Germany.

BACKGROUND: The Communities That Care (CTC) prevention planning and implementation system trains communities throughout a five-phase cycle to (1) build capacity for prevention, (2) adopt science-based prevention, (3) assess the prevention needs of adolescents living in the community, (4) select, and (5) implement evidence-based programs according to their needs. After CTC proved to be effective and cost-effective in the U.S., it is being used by an increasing number of communities in Germany. The aim of this study is to evaluate the effectiveness and cost-effectiveness of CTC in Germany. METHODS: Communities in CTC-phases 1 to 3 (n = 21) and individually-matched comparison communities (n = 21) were recruited for a non-randomised trial. To assess long-term outcomes, (1) a cohort of 5th Grade students will be surveyed biennially concerning behaviours (antisocial behaviour and substance use) and well-being as well as risk and protective factors. Additionally, (2) biennial cross-sectional surveys will be conducted in 6th, 8th, 10th, and 11th Grade in each community. To assess short-term outcomes, a cohort of ten key informants per community will be surveyed biennially concerning adoption of science-based prevention, collaboration, community support and community norms. (4) In a cross-sectional design, all ongoing prevention programs and activities in the communities will be assessed biennially and data will be collected about costs, implementation and other characteristics of the programs and activities. (5) To monitor the CTC implementation, the members of the local CTC-boards will be surveyed annually (cross-sectional design) about team functioning and coalition capacity. Data analysis will include general and generalised mixed models to assess the average treatment effect of CTC. Mediation analyses will be performed to test the logical model, e.g., adoption of science-based prevention as a mediator for the effectiveness of the CTC approach. DISCUSSION: This is the first controlled study to evaluate the effectiveness of a comprehensive community prevention approach in Germany. Evaluating the effectiveness of CTC in Germany is an important prerequisite for further diffusion of the CTC approach. TRIAL REGISTRATION: This study was registered with German Clinical Trial Register: DRKS00022819 on Aug 18, 2021.

"I can do that on my own!" On the relevance of subjective factors to the use of formal support, from the perspective of people with dementia.

Our aim was to reach a better insight of the disposition of people living alone with dementia toward the use of care and support services. In biographical narrative interviews, women and men with dementia communicated to us their opinions, needs, and subjectively perceived level of resources regarding their everyday life and care. Both individual and gender-specific differences concerning the use of formal support become evident in their narrations. We offer indications for a future healthcare practice that is specific to dementia. To fully exploit the potential of participatory research, study designs specific to dementia should be developed further.

Physicians' view on sigmoidoscopy as an additionally offered method for colorectal cancer screening.

BACKGROUND: In Germany, colorectal cancer (CRC) screening includes a fecal blood test or colonoscopy, but not a sigmoidoscopy, which has been shown to reduce CRC incidences and mortality. Our aim was to compile physicians' experiences with sigmoidoscopy and their assessments of this procedure being an additional, possible screening method for early CRC detection. METHODS: At the end of 2015, gastroenterologists and internists in Lower Saxony and North Rhine-Westphalia who regularly perform screening colonoscopies in outpatient care were contacted per mail. Standardized telephone interviews consisting of 17 questions and lasting 10-15 minutes were conducted. RESULTS: Nearly two-thirds (56/87) of the respondents reject sigmoidoscopy as an acceptable early detection method. Compared to colonoscopy, key features of the sigmoidoscopy include more favorable patient-related aspects, while procedural aspects, except sedation, clearly rate in favor of the colonoscopy. In the instance that colonoscopy is rejected, 75 % of the physicians consider a sigmoidoscopy to be a possible alternative. CONCLUSIONS: The survey provides important practical insights into outpatient sigmoidoscopy. A majority of the physicians does not support evidence-based sigmoidoscopy for CRC screening. However, individuals who reject a colonoscopy are, in line with the current guideline, identified as a target group for a screening sigmoidoscopy. The benefit from an additionally offered sigmoidoscopy in CRC screening should be further analyzed with special consideration given to the preferences of insurees within the German healthcare system.

[Public Health Education in Health-Related Study Programs in Germany: Perspectives from Course Coordinators]. / Lehre von Public Health in gesundheitsbezogenen Studiengängen in Deutschland: die Sicht von Studiengangsverantwortlichen.

INTRODUCTION: Public health education in Germany takes place in public health courses and in health-related study courses. We aim to provide data and knowledge on structure and content of health-related study courses and on cooperation between universities and/or Universities of Applied Sciences. METHODS: We conducted an online-based cross-sectional study (01.6. - 15.9.2015), involving 93 universities and Universities of Applied Sciences in Germany. Herewith we addressed 351 study course coordinators. We included course coordinators from universities and Universities of Applied Sciences who were members of the German Association of Social Medicine and Prevention (DGSMP) or in the Association Universities for Health (HOGE). RESULTS: 104 course coordinators responded to the survey (43% men, 57% women). Among others, global health and environmental health are primarily taught in public health courses; ethics and psychology primarily in health-related study courses. Financial support for teaching and research is highly needed at universities and at universities of applied sciences. Furthermore, there is a high need of cooperation between institutions. Additionally, course coordinators from universities of applied sciences indicated a need for cooperative doctoral programs. CONCLUSION: In Germany, competence criteria for teaching public health are missing. Additionally, cooperation between study courses needs to be developed further.

[Factors Associated with Behavioral Problems in Pre-School Age: Secondary Data Analysis of Routine Examination at School Enrolment 2010/2014 in the Hannover Region]. / Welche Faktoren sind mit Verhaltensauffälligkeiten im Vorschulalter assoziiert? Eine Sekundärdatenanalyse der Schuleingangsuntersuchungen von 2010 bis 2014 in der Region Hannover.

BACKGROUND AND AIM: Mental health and the prevalence of behavioral problems in children and adolescents has been gaining increasing concern in the last years. Several studies have addressed this issue in Germany. The aim of the study presented here is to examine factors associated with behavioral problems in pre-school children with focus on untreated morbidity. METHODS: Data from the routine examination at school enrolment from 2010/11 to 2014/15 (n=40,675) in the Hannover region were analyzed. Behavioral problems and socio-emotional competences were assessed by the Strengths and Difficulties Questionnaire (SDQ) for parents and by doctors' observations during examination. Children who had already been treated for behavioral problems at the time of school enrolment were excluded from the study. Using multivariable logistic regression analyses, associations between behavioral problems and sociodemographic factors, duration of kindergarten attendance, family status and gestational age were assessed. RESULTS: Education level of the parents, calculated from both parents' highest school and professional education level, is the strongest predictor for assessing behavioral problems of children at the time of school enrolment examination (OR 2.5; 95%-CI 2.3-2.7). Further factors are male sex (OR 1.5; 95%-CI 1.4-1.6), no kindergarten attendance (OR 1.3; 95%-CI 1.02-1.6) or kindergarten attendance of only one year (OR 1.4; 95%-CI 1.2-1.6), children living without their biological parents (OR 1.7; 95%-CI 1.2-2.4), preterm births (OR 1.5; 95%-CI 1.2-1.8) and age of 5 ½ years and younger (OR 1.4; 95%-CI 1.3-1.6) at the time of examination. CONCLUSION: The results point to the importance of early development support for children from socially disadvantaged families. The results highlight public health-relevant points and enable the region Hannover to improve preventive efforts targeting such pre-school children.

Migration background and childhood overweight in the Hannover Region in 2010-2014: a population-based secondary data analysis of school entry examinations.

Overweight and obesity constitute a global epidemic with rates that are increasing rapidly in children. The aim of the present study was to examine ethnic differences in the prevalence of overweight in pre-school children in a multicultural context. Data were collected from a compulsory school entry examination in the Hannover Region, Germany (n = 50,716) from 2010 to 2014. The prevalence of overweight (including pre-obesity and obesity status) and obesity was estimated using a German national reference. The migration status of the children was based on the parent's migration history. Multivariable logistic and hierarchical multinomial regression analyses were performed to identify factors associated with the overweight, pre-obesity, and obesity status. The prevalence of overweight was significantly higher among migrant children (12.7%) than among the non-migrant children (6.9%). After adjusting for socioeconomic and child development variables, migration background was strongly associated with weight status. The Turkish migrant children showed the highest odds of being pre-obesity (OR 2.05, 95%CI 1.7-2.56) and obesity (OR 2.09, 95%CI 1.67-2.77) compared to non-migrant children. CONCLUSION: Ethnic and social inequalities exist in childhood overweight among pre-school children in the Hannover Region. Thus, appropriate interventions targeting high-risk migrant groups are needed. What is Known: • The current trend of prevalence rates in Germany for overweight and obesity of pre-school children is becoming stable. • Prevalence of overweight and obesity is clearly higher among migrant children than among non-migrant children. What is New: • This article reveals ethnic variance among different migrant groups. • Turkish migrant children have a higher rate of prevalence even compared to other migrant groups. • Length of child day care attendance fails to exert a strong influence on overweight after adjusting for socio-economic and child development variables.

[Dementia in the focus of health research : A comparative analysis of current ageing studies]. / Demenz im Fokus der Gesundheitsforschung : Eine vergleichende Analyse aktueller Altersstudien.

Health research on an increasingly aging population calls for careful consideration of aging-associated phenomena, such as dementia. Accounting for such diseases is a necessary step for gaining a view of health in the elderly. It is moreover imperative to gather data on subjects' mental limitations in surveys to better evaluate the validity of answers disclosed by elderly participants. This article discusses the availability of data on individuals suffering from dementia in national studies on aging. It centers on the question of how surveys respond to the challenge of diagnosing dementia. The analysis is based on a literature review, which focuses on national studies on aging that were conducted no later than 2005, and that enforced an upper age limit of at least 79 years old for their subjects. By evaluating these published studies, and analyzing their data descriptively, it was determined how many subjects suffering from dementia were part of each sample, and which methods were applied to diagnose such illnesses. Overall, the availability of data on age and aging is satisfactory in Germany. The literature review discovered seven studies on aging, as well as five that lend themselves to a framework oriented toward research on aging. The number of subjects suffering from dementia in the samples is between 0 and 14% - over half of the studies reach less than 1.5% of those affected. These results thus point out problems in surveying individuals suffering from dementia. They highlight the limitations of studies on aging that do not account for dementia in their subjects. The following discussion aims to contribute to the debate on relevant research methodology, and to the development of methodological approaches that consider dementia as a crucial factor.

Reaching the Elderly: Understanding of health and preventive experiences for a tailored approach - Results of a qualitative study.

BACKGROUND: Often preventive measures are not accessed by the people who were intended to be reached. Programs for older adults may target men and women, older adults, advanced old age groups and/or chronically ill patients with specific indications. The defined target groups rarely participate in the conception of programs or in the design of information materials, although this would increase accessibility and participation. In the German "Reaching the Elderly" study (2008-2011), an approach to motivating older adults to participate in a preventive home visit (PHV) program was modified with the participatory involvement of the target groups. The study examines how older men and women would prefer to be addressed for health and prevention programs. METHODS: Four focus groups (N = 42 participants) and 12 personal interviews were conducted (women and men in 2 age groups: 65-75 years and ≥ 76 years). Participants from two districts of a major German city were selected from a stratified random sample (N = 200) based on routine data from a local health insurance fund. The study focused on the participants' knowledge about health and disease prevention and how they preferred to be approached and addressed. Videos of the focus groups were recorded and analysed using mind mapping techniques. Interviews were digitally recorded, transcribed verbatim and subjected to qualitative content analysis. RESULTS: A gender-specific approach profile was observed. Men were more likely to favor competitive and exercise-oriented activities, and they associated healthy aging with mobility and physical activity. Women, on the other hand, displayed a broader understanding of healthy aging, which included physical activity as only one aspect as well as a healthy diet, relaxation/wellness, memory training and independent living; they preferred holistic and socially oriented services that were not performance-oriented. The "older seniors" (76+) were ambivalent towards certain wordings referring to aging. CONCLUSIONS: Our results suggest that gender-specific needs must be considered in order to motivate older adults to participate in preventive services. Age-specific characteristics seem to be less relevant. It is more important to pay attention to factors that vary according to the individual state of health and life situation of the potential participants.

Mothers and Fathers Both Matter: The Positive Influence of Parental Physical Activity Modelling on Children's Leisure-Time Physical Activity.

PURPOSE: To investigate associations between maternal and paternal sport participation, and children's leisure-time physical activity, and to explore differences by child gender. METHOD: The sample comprised 737 year five students (mean age: 11.0 ± 0.6 years, 52% male) recruited through the Fit for Pisa Project which was conducted in 2008 at 6 secondary schools in Goettingen, Germany. Maternal and paternal sport participation were assessed through child reports of mothers' and fathers' weekly participation in sport. Children's leisure-time physical activity was measured as minutes/week that children engaged in organized and nonorganized sport. Multiple linear regression was used to assess associations between maternal and paternal sport participation, and children's leisure-time physical activity. RESULTS: Both maternal and paternal sport participation were positively associated with children's leisure-time physical activity (maternal: b = 34.20, p < .001; paternal: b = 25.32, p < .05). When stratifying analyses by child gender, maternal sport participation remained significantly associated with leisure-time physical activity in girls (b = 60.64, p < .001). In contrast, paternal sport participation remained significantly associated with leisure-time physical activity in boys (b = 43.88, p < .01). CONCLUSION: Both maternal and paternal modeling positively influence children's leisure-time physical activity.

[Non-selective primary prevention programs for childhood overweight : An overview]. / Universelle Programme zur Primärprävention kindlichen Übergewichts : Ein Überblick.

BACKGROUND: Despite an obvious stabilization the prevalence of childhood overweight and obesity is still too high. Since childhood obesity may track into adulthood and lead to major health consequences, effective primary prevention programs are of high relevance. OBJECTIVE: In recent years several universal primary prevention programs, measures or projects have been developed and evaluated in Germany. This paper gives an overview. METHODS: An internet search and a search in the archive of the Deutsche Ärzteblatt were conducted to identify universal programs in Germany from 2006 to 2015. We used the combination of primary prevention, children, obesity and project for this online search. RESULTS: We identified 38 programs and measures. After exclusion of non-adequate interventions (e. g. selective instead of universal) and any duplicates we selected 13 projects to be described. DISCUSSION: Some projects provided insufficient information since they have not been adequately published. On the positive side, most projects simultaneously addressed various potential risk factors and achieved a successful networking of various relevant actors. In addition, many projects strived for creating the groundwork to allow for a sustainable change in the living environment of children. However, despite the fact that the concept of most projects was theory-based in most cases only weak intervention effects were observed on strong endpoints like anthropometric indicators and on health-related behaviors.

[Effectiveness of combined interventions for the prevention of overweight for children and youths : A systematic review]. / Wirksamkeit kombinierter Interventionen zur Prävention von Übergewicht bei Kindern und Jugendlichen : Ein systematisches Review.

BACKGROUND: Prevalence rates of overweight children and youths remain high meaning that preventive measures are still necessary. Combined interventions are rated highly in the field of overweight prevention, particularly with regard to the key areas of diet, physical activity and life skills. OBJECTIVES: It is our aim to give an overview of current studies with combined interventions for the prevention of overweight, to derive comprehensive insights and to identify knowledge gaps. METHODS: A systematic review of combined interventions for 6-16 year old children and youths forms the basis of this contribution. Twelve data bases, the internet and references were searched for controlled studies. Study quality was appraised with the EPHPP-tool; if randomisation was present the risk of bias was assessed. Studies with the explicit aim of preventing overweight were analysed separately. RESULTS: Thirteen studies remained from 12,136 screened titles. Interventions were school-based and occasionally different intervention sites were linked to each other. All 13 interventions involved measures focusing on diet, physical activity and life skills; measures targeting structures and conditions were inadequately represented. The duration of intervention and follow-up time points varied widely. More than half of the studies reported positive effects on body mass index. CONCLUSIONS: The number of published controlled studies with combined interventions is surprisingly low. With regard to the prevention of overweight, the potential of life skills programs seems not yet to be exhausted; measures targeting structures and conditions are insufficiently utilised.

Intended and Actual Participation in the Colorectal Cancer Screening Program­a Prospective Cohort Study With AOK Insurees.

BACKGROUND: The public generally has a positive view of colorectal cancer screening, but there is still room for improvement in participation rates. The aim of this study was to identify factors that are associated with intended and actual participation. METHODS: We conducted a prospective cohort study of a random sample of insurees of the AOK (a statutory health insurance carrier) in the German federal state of Lower Saxony. 50-year-old men and 55-year-old women who were eligible for their first screening colonoscopy received a written questionnaire in June 2020, three weeks after being invited to undergo colorectal cancer screening. For those who intended to do so, we used multivariable logistic regression analysis to determine any statistical associations between sociodemographic and medical characteristics and participation rates within 30 months. RESULTS: 82.7% of the respondents (239/298) intended to participate, and 43.3% (129/298) actually did so within 30 months. The participation rates among persons who had already decided to have a stool test or a colonoscopy were 50.7% (36/71) and 55.2% (58/105), respectively; the participation rate among undecided persons was 33.3% (19/57). The strongest association in the regression model was with an already made appointment (OR = 11.1, 95% confidence interval: [3.9; 31.8]). After exclusion of the existing-appointment variable from the regression model, living in a smaller town (OR = 2.41 [1.08; 5.35]) and a stated preference for colonoscopy (OR = 2.52; [1.20; 5.27]) were positively associated with participation. Insurees with a parent affected by colorectal cancer participated less frequently, even after adjustment for prior colonoscopies (OR = 0.31 [0.12; 0.80]). CONCLUSION: The wide gap between intended and actual participation implies that there is potential for improvement in the prevention of colorectal cancer, and that certain groups of people could benefit from targeted support in making their intention to undergo screening a reality. Because of the methodological limitations of this initial investigation, its findings need to be confirmed by further studies.

Incidence and long-term risk of de novo malignancies after liver transplantation with implications for prevention and detection.

The goal of this study was the characterization of long-term cancer risks after liver transplantation (LT) with implications for prevention and detection. Site-specific cancer incidence rates and characteristics were compared retrospectively for 2000 LT patients from a single institution (January 1, 1983 to December 31, 2010) and the general German population with standardized incidence ratios (SIRs); the total follow-up at December 31, 2011 was 14,490 person-years. The cancer incidence rates for the LT recipients were almost twice as high as those for the age- and sex-matched general population (SIR = 1.94, 95% CI = 1.63-2.31). Significantly increased SIRs were observed for vulvar carcinoma (SIR = 23.80), posttransplant lymphoproliferative disorder/non-Hodgkin lymphoma (SIR = 10.95), renal cell carcinoma (SIR = 2.65), lung cancer (SIR = 1.85), and colorectal cancer (SIR = 1.41). The mean time between transplantation and diagnosis was 6.8 years. The mean age at the time of diagnosis was significantly lower for the cohort versus the general population with similar malignancies [50 years (both sexes) versus 69 and 68 years (males and females), P ≤ 0.006]. Tumors were diagnosed at more advanced stages, and there was a trend of higher grading, which suggested more aggressive tumor growth. Tumor treatment was performed according to accepted guidelines. Surprisingly, 5-year survival was slightly better in the study cohort versus the general population for renal cell carcinoma, lung cancer, colorectal cancer, and thyroid cancer. Long-term immunosuppression with different protocols did not lead to significantly different SIRs, although patients treated with mycophenolate mofetil had the lowest SIR for de novo cancers (1.65, 95% CI = 1.2-2.4). Alcoholic liver disease (SIR = 2.30) and primary sclerosing cholangitis (SIR = 3.40) as indications for LT were associated with an increased risk of de novo malignancies. In conclusion, risk-adapted cancer surveillance is proposed. Tumor treatment performed according to accepted guidelines appears adequate. Mycophenolate may lead to lower long-term risks for de novo cancers.

Do preschools differ in promoting children's physical activity? An instrument for the assessment of preschool physical activity programmes.

BACKGROUND: Preschools offer high potential for preventive interventions. However, little is known about the structure of preschool programmes to promote physical activity (PA) in preschoolers although almost all children aged three to six years spend one third of the day at preschool. The aim of this study was to determine whether and to what extent preschools implement systematic PA promotion measures using an instrument specifically developed to assess and systematize preschool PA programmes. METHODS: In the cross-sectional study a baseline survey of preschool education policies was conducted to identify and assess the type and extent of PA programmes and opportunities in preschools in the State of Lower Saxony, Germany. An assessment instrument was developed to identify preschools with systematic PA programmes (type 1) and those without PA programmes (type 2) based on the following quality criteria: A) written PA policy, B) structured weekly PA offerings for all children; C) at least one qualified physical education teacher; D) PA-friendly indoor and outdoor facilities (exercise room, situational PA opportunities, outdoor areas, play equipment etc.), and E) structured PA promotion in place for at least two years. A third type of preschool that promotes PA in children to some extent (i.e., that meets the criteria partially but not completely) was classified as "preschools with limited PA programmes". RESULTS: 2415 preschools participated in the survey (response rate: 59%). The results show that 26% (n = 554) have a systematic PA programme while 3% (n = 64) have no PA programme. Most (71%, n = 1514) were classified as limited PA programme preschools. All three types of preschools differed significantly (p = .000) from each other in terms of size (small vs. large). Most of the preschools without PA programmes are small half-day preschools. CONCLUSIONS: The study investigated an assessment-instrument providing extensive insight into the nature, extent and routine practical implementation of PA promotion in preschools. The criteria used to evaluate preschool PA programmes are well-suited to identify the different preschool PA programme types and target areas in the field of PA promotion in which specific measures (teacher education, structured PA offerings, etc.) can be implemented in future interventions.