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1.
Science ; 378(6624): 1092-1097, 2022 12 09.
Artículo en Inglés | MEDLINE | ID: mdl-36480631

RESUMEN

Programming is a powerful and ubiquitous problem-solving tool. Systems that can assist programmers or even generate programs themselves could make programming more productive and accessible. Recent transformer-based neural network models show impressive code generation abilities yet still perform poorly on more complex tasks requiring problem-solving skills, such as competitive programming problems. Here, we introduce AlphaCode, a system for code generation that achieved an average ranking in the top 54.3% in simulated evaluations on recent programming competitions on the Codeforces platform. AlphaCode solves problems by generating millions of diverse programs using specially trained transformer-based networks and then filtering and clustering those programs to a maximum of just 10 submissions. This result marks the first time an artificial intelligence system has performed competitively in programming competitions.

2.
Med Image Comput Comput Assist Interv ; 17(Pt 2): 154-61, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-25485374

RESUMEN

In this work we propose a novel framework for generic event monitoring in live cell culture videos, built on the assumption that unpredictable observations should correspond to biological events. We use a small set of event-free data to train a multioutput multikernel Gaussian process model that operates as an event predictor by performing autoregression on a bank of heterogeneous features extracted from consecutive frames of a video sequence. We show that the prediction error of this model can be used as a probability measure of the presence of relevant events, that can enable users to perform further analysis or monitoring of large-scale non-annotated data. We validate our approach in two phase-contrast sequence data sets containing mitosis and apoptosis events: a new private dataset of human bone cancer (osteosarcoma) cells and a benchmark dataset of stem cells.


Asunto(s)
Ciclo Celular , Rastreo Celular/métodos , Microscopía de Contraste de Fase/métodos , Osteosarcoma/patología , Reconocimiento de Normas Patrones Automatizadas/métodos , Células Madre/citología , Técnica de Sustracción , Algoritmos , Células Cultivadas , Simulación por Computador , Interpretación Estadística de Datos , Humanos , Aumento de la Imagen/métodos , Interpretación de Imagen Asistida por Computador/métodos , Modelos Estadísticos , Reproducibilidad de los Resultados , Sensibilidad y Especificidad
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