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1.

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.

Schreiber, Stuart L; Kotz, Joanne D; Li, Min; Aubé, Jeffrey; Austin, Christopher P; Reed, John C; Rosen, Hugh; White, E Lucile; Sklar, Larry A; Lindsley, Craig W; Alexander, Benjamin R; Bittker, Joshua A; Clemons, Paul A; de Souza, Andrea; Foley, Michael A; Palmer, Michelle; Shamji, Alykhan F; Wawer, Mathias J; McManus, Owen; Wu, Meng; Zou, Beiyan; Yu, Haibo; Golden, Jennifer E; Schoenen, Frank J; Simeonov, Anton; Jadhav, Ajit; Jackson, Michael R; Pinkerton, Anthony B; Chung, Thomas D Y; Griffin, Patrick R; Cravatt, Benjamin F; Hodder, Peter S; Roush, William R; Roberts, Edward; Chung, Dong-Hoon; Jonsson, Colleen B; Noah, James W; Severson, William E; Ananthan, Subramaniam; Edwards, Bruce; Oprea, Tudor I; Conn, P Jeffrey; Hopkins, Corey R; Wood, Michael R; Stauffer, Shaun R; Emmitte, Kyle A.

Cell ; 161(6): 1252-65, 2015 Jun 04.

Artículo en Inglés | MEDLINE | ID: mdl-26046436

2.

Revisiting the ß-Lactams for Tuberculosis Therapy with a Compound-Compound Synthetic Lethality Approach.

Xiao, Shiqi; Guo, Haidan; Weiner, Warren S; Maddox, Clinton; Mao, Chunhong; Gunosewoyo, Hendra; Pelly, Shaaretha; White, E Lucile; Rasmussen, Lynn; Schoenen, Frank J; Aubé, Jeffrey; Bishai, William R; Lun, Shichun.

Antimicrob Agents Chemother ; 63(11)2019 11.

Artículo en Inglés | MEDLINE | ID: mdl-31427291

3.

Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells.

Oliva, Claudia R; Markert, Tahireh; Ross, Larry J; White, E Lucile; Rasmussen, Lynn; Zhang, Wei; Everts, Maaike; Moellering, Douglas R; Bailey, Shannon M; Suto, Mark J; Griguer, Corinne E.

J Biol Chem ; 291(46): 24188-24199, 2016 Nov 11.

Artículo en Inglés | MEDLINE | ID: mdl-27679486

4.

Discovery of Clinically Approved Agents That Promote Suppression of Cystic Fibrosis Transmembrane Conductance Regulator Nonsense Mutations.

Mutyam, Venkateshwar; Du, Ming; Xue, Xiaojiao; Keeling, Kim M; White, E Lucile; Bostwick, J Robert; Rasmussen, Lynn; Liu, Bo; Mazur, Marina; Hong, Jeong S; Falk Libby, Emily; Liang, Feng; Shang, Haibo; Mense, Martin; Suto, Mark J; Bedwell, David M; Rowe, Steven M.

Am J Respir Crit Care Med ; 194(9): 1092-1103, 2016 11 01.

Artículo en Inglés | MEDLINE | ID: mdl-27104944

5.

Discovery of a novel inhibitor of kinesin-like protein KIFC1.

Zhang, Wei; Zhai, Ling; Wang, Yimin; Boohaker, Rebecca J; Lu, Wenyan; Gupta, Vandana V; Padmalayam, Indira; Bostwick, Robert J; White, E Lucile; Ross, Larry J; Maddry, Joseph; Ananthan, Subramaniam; Augelli-Szafran, Corinne E; Suto, Mark J; Xu, Bo; Li, Rongbao; Li, Yonghe.

Biochem J ; 473(8): 1027-35, 2016 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-26846349

6.

Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein.

Pery, Erez; Sheehy, Ann; Nebane, N Miranda; Brazier, Andrew Jay; Misra, Vikas; Rajendran, Kottampatty S; Buhrlage, Sara J; Mankowski, Marie K; Rasmussen, Lynn; White, E Lucile; Ptak, Roger G; Gabuzda, Dana.

J Biol Chem ; 290(16): 10504-17, 2015 Apr 17.

Artículo en Inglés | MEDLINE | ID: mdl-25724652

7.

Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.

Chung, Dong-Hoon; Jonsson, Colleen B; Tower, Nichole A; Chu, Yong-Kyu; Sahin, Ergin; Golden, Jennifer E; Noah, James W; Schroeder, Chad E; Sotsky, Julie B; Sosa, Melinda I; Cramer, Daniel E; McKellip, Sara N; Rasmussen, Lynn; White, E Lucile; Schmaljohn, Connie S; Julander, Justin G; Smith, Jeffrey M; Filone, Claire Marie; Connor, John H; Sakurai, Yasuteru; Davey, Robert A.

PLoS Pathog ; 10(6): e1004213, 2014 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-24967809

8.

Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.

Liu, Zhiyong; Galemmo, Robert A; Fraser, Kyle B; Moehle, Mark S; Sen, Saurabh; Volpicelli-Daley, Laura A; DeLucas, Lawrence J; Ross, Larry J; Valiyaveettil, Jacob; Moukha-Chafiq, Omar; Pathak, Ashish K; Ananthan, Subramaniam; Kezar, Hollis; White, E Lucile; Gupta, Vandana; Maddry, Joseph A; Suto, Mark J; West, Andrew B.

J Biol Chem ; 289(47): 32937-51, 2014 Nov 21.

Artículo en Inglés | MEDLINE | ID: mdl-25228699

9.

A cell based high-throughput screening approach for the discovery of new inhibitors of respiratory syncytial virus.

Chung, Dong-Hoon; Moore, Blake P; Matharu, Daljit S; Golden, Jennifer E; Maddox, Clinton; Rasmussen, Lynn; Sosa, Melinda I; Ananthan, Subramaniam; White, E Lucile; Jia, Fuli; Jonsson, Colleen B; Severson, William E.

Virol J ; 10: 19, 2013 Jan 10.

Artículo en Inglés | MEDLINE | ID: mdl-23302182

10.

NIH: translation centre bridges a gap.

Reed, John C; White, E Lucile.

Nature ; 474(7350): 161, 2011 Jun 08.

Artículo en Inglés | MEDLINE | ID: mdl-21654789

11.

A high-throughput screening assay for inhibitors of bacterial motility identifies a novel inhibitor of the Na+-driven flagellar motor and virulence gene expression in Vibrio cholerae.

Rasmussen, Lynn; White, E Lucile; Pathak, Ashish; Ayala, Julio C; Wang, Hongxia; Wu, Jian-He; Benitez, Jorge A; Silva, Anisia J.

Antimicrob Agents Chemother ; 55(9): 4134-43, 2011 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-21709090

12.

Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.

Manuvakhova, Marina S; Johnson, Guyla G; White, Misti C; Ananthan, Subramaniam; Sosa, Melinda; Maddox, Clinton; McKellip, Sara; Rasmussen, Lynn; Wennerberg, Krister; Hobrath, Judith V; White, E Lucile; Maddry, Joseph A; Grimaldi, Maurizio.

J Neurosci Res ; 89(1): 58-72, 2011 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-21046675

13.

Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.

Mathew, Bini; Srivastava, Shefali; Ross, Larry J; Suling, William J; White, E Lucile; Woolhiser, Lisa K; Lenaerts, Anne J; Reynolds, Robert C.

Bioorg Med Chem ; 19(23): 7120-8, 2011 Dec 01.

Artículo en Inglés | MEDLINE | ID: mdl-22024272

14.

A high-throughput screen for chemical inhibitors of exocytic transport in yeast.

Zhang, Lisha; Nebane, N Miranda; Wennerberg, Krister; Li, Yujie; Neubauer, Valerie; Hobrath, Judith V; McKellip, Sara; Rasmussen, Lynn; Shindo, Nice; Sosa, Melinda; Maddry, Joseph A; Ananthan, Subramaniam; Piazza, Gary A; White, E Lucile; Harsay, Edina.

Chembiochem ; 11(9): 1291-301, 2010 Jun 14.

Artículo en Inglés | MEDLINE | ID: mdl-20461743

15.

HTS-driven discovery of new chemotypes with West Nile Virus inhibitory activity.

Chung, Dong Hoon; Jonsson, Colleen B; Maddox, Clinton; McKellip, Sara N; Moore, Blake P; Heil, Marintha; White, E Lucile; Ananthan, Subramaniam; Li, Qianjun; Feng, Shuang; Rasmussen, Lynn.

Molecules ; 15(3): 1690-704, 2010 Mar 12.

Artículo en Inglés | MEDLINE | ID: mdl-20336008

16.

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis TypeâIII Pantothenate Kinase (PanK).

Shapiro, Justin A; Varga, John J; Parsonage, Derek; Walton, William; Redinbo, Matthew R; Ross, Larry J; White, E Lucile; Bostwick, Robert; Wuest, William M; Claiborne, Al; Goldberg, Joanna B.

ChemMedChem ; 14(1): 78-82, 2019 01 08.

Artículo en Inglés | MEDLINE | ID: mdl-30376607

17.

High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2).

Severson, William E; McDowell, Michael; Ananthan, Subramaniam; Chung, Dong-Hoon; Rasmussen, Lynn; Sosa, Melinda I; White, E Lucile; Noah, James; Jonsson, Colleen B.

J Biomol Screen ; 13(9): 879-87, 2008 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-18812571

18.

Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits.

Mukherjee, Prasenjit; Desai, Prashant; Ross, Larry; White, E Lucile; Avery, Mitchell A.

Bioorg Med Chem ; 16(7): 4138-49, 2008 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-18343121

19.

Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library.

Severson, William E; Shindo, Nice; Sosa, Mindy; Fletcher, Thomas; White, E Lucile; Ananthan, Subramaniam; Jonsson, Colleen B.

J Biomol Screen ; 12(1): 33-40, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-17200104

20.

A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase.

White, E Lucile; Southworth, Kristen; Ross, Larry; Cooley, Sara; Gill, Rachel B; Sosa, Melinda Ingrum; Manouvakhova, Anna; Rasmussen, Lynn; Goulding, Celia; Eisenberg, David; Fletcher, Thomas M.

J Biomol Screen ; 12(1): 100-5, 2007 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-17175524

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