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1.

Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin.

Hemmert, Andrew C; Otto, Tamara C; Wierdl, Monika; Edwards, Carol C; Fleming, Christopher D; MacDonald, Mary; Cashman, John R; Potter, Philip M; Cerasoli, Douglas M; Redinbo, Matthew R.

Mol Pharmacol ; 77(4): 508-16, 2010 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-20051531

2.

Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.

Danks, Mary K; Yoon, K Jin; Bush, Rebecca A; Remack, Joanna S; Wierdl, Monika; Tsurkan, Lyudmila; Kim, Seung U; Garcia, Elizabeth; Metz, Marianne Z; Najbauer, Joseph; Potter, Philip M; Aboody, Karen S.

Cancer Res ; 67(1): 22-5, 2007 Jan 01.

Artículo en Inglés | MEDLINE | ID: mdl-17210679

3.

Modifications of human carboxylesterase for improved prodrug activation.

Hatfield, Jason M; Wierdl, Monika; Wadkins, Randy M; Potter, Philip M.

Expert Opin Drug Metab Toxicol ; 4(9): 1153-65, 2008 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-18721110

4.

Targeting ALK in pediatric RMS does not induce antitumor activity in vivo.

Wierdl, Monika; Tsurkan, Lyudmila; Chi, Liying; Hatfield, M Jason; Tollemar, Viktor; Bradley, Cori; Chen, Xiang; Qu, Chunxu; Potter, Philip M.

Cancer Chemother Pharmacol ; 82(2): 251-263, 2018 08.

Artículo en Inglés | MEDLINE | ID: mdl-29855693

5.

Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

Hyatt, Janice L; Moak, Teri; Hatfield, M Jason; Tsurkan, Lyudmila; Edwards, Carol C; Wierdl, Monika; Danks, Mary K; Wadkins, Randy M; Potter, Philip M.

J Med Chem ; 50(8): 1876-85, 2007 Apr 19.

Artículo en Inglés | MEDLINE | ID: mdl-17378546

6.

Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity.

Hyatt, Janice L; Tsurkan, Lyudmila; Wierdl, Monika; Edwards, Carol C; Danks, Mary K; Potter, Philip M.

Mol Cancer Ther ; 5(9): 2281-8, 2006 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-16985062

7.

Tumour-selective targeting of drug metabolizing enzymes to treat metastatic cancer.

Wierdl, Monika; Tsurkan, Lyudmila; Hatfield, M Jason; Potter, Philip M.

Br J Pharmacol ; 173(19): 2811-8, 2016 10.

Artículo en Inglés | MEDLINE | ID: mdl-27423046

8.

Carboxylesterases: General detoxifying enzymes.

Hatfield, M Jason; Umans, Robyn A; Hyatt, Janice L; Edwards, Carol C; Wierdl, Monika; Tsurkan, Lyudmila; Taylor, Michael R; Potter, Philip M.

Chem Biol Interact ; 259(Pt B): 327-331, 2016 Nov 25.

Artículo en Inglés | MEDLINE | ID: mdl-26892220

9.

Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.

Wadkins, Randy M; Hyatt, Janice L; Wei, Xin; Yoon, Kyoung Jin P; Wierdl, Monika; Edwards, Carol C; Morton, Christopher L; Obenauer, John C; Damodaran, Komath; Beroza, Paul; Danks, Mary K; Potter, Philip M.

J Med Chem ; 48(8): 2906-15, 2005 Apr 21.

Artículo en Inglés | MEDLINE | ID: mdl-15828829

10.

Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.

Hyatt, Janice L; Stacy, Vanessa; Wadkins, Randy M; Yoon, Kyoung Jin P; Wierdl, Monika; Edwards, Carol C; Zeller, Matthias; Hunter, Allen D; Danks, Mary K; Crundwell, Guy; Potter, Philip M.

J Med Chem ; 48(17): 5543-50, 2005 Aug 25.

Artículo en Inglés | MEDLINE | ID: mdl-16107154

11.

Update on gene therapy approaches for cancer.

Wierdl, Monika; Potter, Philip M.

Curr Hematol Rep ; 4(4): 294-9, 2005 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-16009044

12.

Targeting oxidative stress in embryonal rhabdomyosarcoma.

Chen, Xiang; Stewart, Elizabeth; Shelat, Anang A; Qu, Chunxu; Bahrami, Armita; Hatley, Mark; Wu, Gang; Bradley, Cori; McEvoy, Justina; Pappo, Alberto; Spunt, Sheri; Valentine, Marcus B; Valentine, Virginia; Krafcik, Fred; Lang, Walter H; Wierdl, Monika; Tsurkan, Lyudmila; Tolleman, Viktor; Federico, Sara M; Morton, Chris; Lu, Charles; Ding, Li; Easton, John; Rusch, Michael; Nagahawatte, Panduka; Wang, Jianmin; Parker, Matthew; Wei, Lei; Hedlund, Erin; Finkelstein, David; Edmonson, Michael; Shurtleff, Sheila; Boggs, Kristy; Mulder, Heather; Yergeau, Donald; Skapek, Steve; Hawkins, Douglas S; Ramirez, Nilsa; Potter, Philip M; Sandoval, John A; Davidoff, Andrew M; Mardis, Elaine R; Wilson, Richard K; Zhang, Jinghui; Downing, James R; Dyer, Michael A.

Cancer Cell ; 24(6): 710-24, 2013 Dec 09.

Artículo en Inglés | MEDLINE | ID: mdl-24332040

13.

Global and local molecular dynamics of a bacterial carboxylesterase provide insight into its catalytic mechanism.

Yu, Xiaozhen; Sigler, Sara C; Hossain, Delwar; Wierdl, Monika; Gwaltney, Steven R; Potter, Philip M; Wadkins, Randy M.

J Mol Model ; 18(6): 2869-83, 2012 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-22127613

14.

Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Hemmert, Andrew C; Otto, Tamara C; Chica, Roberto A; Wierdl, Monika; Edwards, Jonathan S; Lewis, Steven M; Lewis, Steven L; Edwards, Carol C; Tsurkan, Lyudmila; Cadieux, C Linn; Kasten, Shane A; Cashman, John R; Mayo, Stephen L; Potter, Philip M; Cerasoli, Douglas M; Redinbo, Matthew R.

PLoS One ; 6(3): e17441, 2011 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-21445272

15.

Evaluation of the 'side door' in carboxylesterase-mediated catalysis and inhibition.

Streit, Timothy M; Borazjani, Abdolsamad; Lentz, Shellaine E; Wierdl, Monika; Potter, Philip M; Gwaltney, Steven R; Ross, Matthew K.

Biol Chem ; 389(2): 149-62, 2008 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-18163883

16.

Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

Hicks, Latorya D; Hyatt, Janice L; Moak, Teri; Edwards, Carol C; Tsurkan, Lyudmila; Wierdl, Monika; Ferreira, Antonio M; Wadkins, Randy M; Potter, Philip M.

Bioorg Med Chem ; 15(11): 3801-17, 2007 Jun 01.

Artículo en Inglés | MEDLINE | ID: mdl-17399985

17.

Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model.

Wierdl, Monika; Morton, Christopher L; Nguyen, Nathan K; Redinbo, Matthew R; Potter, Philip M.

Biochemistry ; 43(7): 1874-82, 2004 Feb 24.

Artículo en Inglés | MEDLINE | ID: mdl-14967028

18.

p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11).

Wierdl, Monika; Morton, Christopher L; Harris, Linda C; Danks, Mary K; Schuetz, John D; Potter, Philip M.

J Pharmacol Exp Ther ; 304(2): 699-705, 2003 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-12538824

19.

Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance.

Wierdl, Monika; Wall, Amelia; Morton, Christopher L; Sampath, Janardhan; Danks, Mary K; Schuetz, John D; Potter, Philip M.

Mol Pharmacol ; 64(2): 279-88, 2003 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-12869632

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