1.
Tetrahedron
; 64(35): 8045-8051, 2008 Aug 25.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19710906
RESUMEN
Sequential exposure of a zinc-organometallic intermediate, generated through a zinc carbenoid-mediated chain extension reaction of a beta-keto carbonyl, to trimethylsilylchloride and iodine provided regioselective formation of an alpha-iodomethyl-gamma-keto carbonyl. The iodomethyl functionality can be further manipulated to provide side chains that are potential mimics of alpha-amino acid side chains.