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Bioorg Med Chem Lett
; 17(16): 4657-63, 2007 Aug 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-17570666
RESUMEN
A structure-activity relationship study was conducted on a series of tetrahydro-beta-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2). The compounds were further evaluated for their ability to inhibit TNFalpha production in U937 cells and in vivo. These compounds represent a novel structural class of compounds capable of inhibiting MK-2 with remarkable selectivity.