RESUMEN
Background/aim: Craniocervical junction (CCJ) can be involved in inflammatory arthritis. We aimed to define types of CCJ involvement in rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) and compare them with patients without inflammatory arthritides. Materials and methods: In this retrospective analysis, cervical CT or MRIs of patients with RA, SpA, or PsA, taken for any reason between 2010 and 2020, according to ICD-10 codes, were scanned. Demographic data of the patients were recorded. CCJ involvements (atlantoaxial, vertical, or subaxial subluxation, odontoid process involvement) were reevaluated by an experienced radiologist. The control group consisted of consecutive patients without inflammatory arthritis. Results: Exactly 459 patients (204 RA, 200 SpA, and 55 PsA) and 78 patients in the control group were included in the study. CCJ involvement was detected in 101 (49.5%) RA, 53 (26.5%) SpA, 10 (18.2%) PsA, and 4 patients (5.1%) in the control group (p < 0.001). The odontoid process was one of the main targets, especially in RA patients (69 (33.8%)), which was significantly higher than in the SpA, PsA, and control groups. Although vertical subluxation (VS) was numerically higher in the RA and SpA groups compared to the control group, VS-related brainstem compression was relatively uncommon: 6 (2.9%) in RA, 1 (0.5%) in AS, and none in the PsA and control groups. Conclusion: CCJ involvement can often be detected in patients with inflammatory arthritis, especially in RA and SpA patients. The odontoid process is the main target of inflammation.
Asunto(s)
Artritis Reumatoide , Imagen por Resonancia Magnética , Tomografía Computarizada por Rayos X , Humanos , Femenino , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Artritis Reumatoide/diagnóstico por imagen , Artritis Reumatoide/complicaciones , Adulto , Espondiloartritis/diagnóstico por imagen , Anciano , Artritis Psoriásica/diagnóstico por imagen , Articulación Atlantoaxoidea/diagnóstico por imagen , Vértebras Cervicales/diagnóstico por imagen , Apófisis Odontoides/diagnóstico por imagenRESUMEN
In this study, nanoparticle-incorporated nanofiber-covered yarns were prepared using a custom-made needle-free electrospinning system. The ultimate goal of this work was to prepare functional nanofibrous surfaces with antibacterial properties and realize high-speed production. As antibacterial agents, we used various amounts of copper oxide (CuO) and vanadium (V) oxide (V2O5) nanoparticles (NPs). Three yarn preparation speeds (100 m/min, 150 m/min, and 200 m/min) were used for the nanofiber-covered yarn. The results indicate a relationship between the yarn speed, quantity of NPs, and antibacterial efficiency of the material. We found a higher yarn speed to be associated with a lower reduction in bacteria. NP-loaded nanofiber yarns were proven to have excellent antibacterial properties against Gram-negative Escherichia coli (E. coli). CuO exhibited a greater inhibition and bactericidal effect against E. coli than V2O5. In brief, the studied samples are good candidates for use in antibacterial textile surface applications, such as wastewater filtration. As greater attention is being drawn to this field, this work provides new insights regarding the antibacterial textile surfaces of nanofiber-covered yarns.
Asunto(s)
Antibacterianos/química , Nanofibras/química , Polivinilos/química , Cobre/química , Vanadio/químicaRESUMEN
INTRODUCTION: The aims of this study were to evaluate the frequency and causes of hospitalizations in the posttransplant period of children, investigate the risk factors, and evaluate the relationship between hospitalizations and renal prognosis in the long term. METHODS: We retrospectively reviewed the files of pediatric renal transplant patients, followed at least 6 months after kidney transplantation, in our center. Clinical information including age at transplantation, gender, primary disease, donor type, immuno-suppressive medication, hospitalization dates, and indications (infections and non-infectious) during follow-up period and graft outcomes was recorded. RESULTS: A total of 74 children (46 males) were followed up for a median of 54 months. Among them, 69 patients (93.2%) were hospitalized 446 times. The most common cause of hospitalizations was infections (314 times, 70%). Urinary tract infections were the most important cause followed by upper respiratory tract infections. Forty (54%) patients were hospitalized 132 times (29.5%) for non-infectious reasons. The most common non-infectious reason was nonspecific graft dysfunction (19 patients, 30 times), followed by rejection (17 patients, 27 times). Younger age, use of induction therapy, and having congenital anomalies of kidney and urinary tract (CAKUT) were found to be risk factors for increased hospitalization rates (p < 0.05). The number of hospitalizations was found to be negatively affecting the final glomerular filtration rate of transplant recipients (p: 0.04, r: -0.023). CONCLUSION: Patients with CAKUT, who received induction therapy, and small children were hospitalized more frequently after transplantation. Strategies to prevent hospitalizations will achieve a better graft prognosis.
Asunto(s)
Trasplante de Riñón , Anomalías Urogenitales , Reflujo Vesicoureteral , Masculino , Humanos , Niño , Trasplante de Riñón/efectos adversos , Estudios Retrospectivos , Rechazo de Injerto , Factores de Riesgo , HospitalizaciónRESUMEN
Microbial fuel cells (MFCs) represent simple devices that harness the metabolic activities of microorganisms to produce electrical energy from diverse sources such as organic waste and sustainable biomass. Because of their unique advantage to generate sustainable energy, through the employment of biodegradable and repurposed waste materials, the development of MFCs has garnered considerable interest. Critical elements are typically the electrodes and separator. This mini-review article presents a critical assessment of nanofiber technology used as electrodes and separators in MFCs to enhance energy generation. In particular, the review highlights the application of nanofiber webs in each part of MFCs including anodes, cathodes, and membranes and their influence on energy generation. The role of nanofiber technology in this regard is then analysed in detail, focusing on improved electron transfer rate, enhanced biofilm formation, and enhanced durability and stability. In addition, the challenges and opportunities associated with integrating nanofibers into MFCs are discussed, along with suggestions for future research in this field. Significant developments in MFCs over the past decade have led to a several-fold increase in achievable power density, yet further improvements in performance and the exploration of cost-effective materials remain promising areas for further advancement. This review demonstrates the great promise of nanofiber-based electrodes and separators in future applications of MFCs.
RESUMEN
A novel approach was proposed, utilizing an electrical field and X-ray irradiation to oxidize elemental mercury (Hg0) and encapsulate it within a nanofibrous mat made of Polyamide 6/Chitosan. The X-rays contributed significantly to the conversion of Hg0 into Hg+ by producing electrons through the photoionization of gas molecules. The positive and negative pole electrodes generated an electric field that exerted a magnetic force, resulting in the redirection of oxidized elemental mercury towards the negative pole electrode, which was coupled with a Polyamide 6/Chitosan nanofiber mat. The evaluation of the Polyamide 6/Chitosan nanofibers exposed to oxidized mercury showed that the mercury, found in the steam of a specially designed filtration device, was captured in two different forms. Firstly, it was chemically bonded with concentrations ranging from 0.2 to 10 ng of Hg in total. Secondly, it was retained on the surface of the Polyamide 6/Chitosan nanofibers with a concentration of 10 microg/m3 of Hg per minute. Nevertheless, a concentration of 10 microg/m3 of mercury is considered significant, given that the emission levels of mercury from each coal power plant typically vary from approximately 4.72 to 44.07 microg/m3. Thus, this research presents a viable approach to reducing mercury emissions from coal-fired power plants, which could result in lower operational expenses and less secondary environmental effects.
RESUMEN
Acquired Bartter-like syndrome (BLS), characterized by hypokalemic metabolic alkalosis, hypomagnesemia, hypocalcemia, and normal kidney function, can be induced by diuretics or antibiotics. It is a very rare condition and only anecdotal cases mostly in adults were reported. Although tubulopathy associated with colistin was reported in adults, to the best of our knowledge, colistin-associated BLS neither in adults nor in children has been reported in the literature. We here report a-28-week, 740 g female preterm infant who developed BLS just after colistin treatment for Acinetobacter baumannii infection and recovered few days after the drug cessation, and discuss the possible association of colistin and tubulopathy. More research on colistin pharmacokinetics and pharmacodynamics in critically ill patients and preterm infants is needed to guide adequate colistin dosing at the least toxicity.
Asunto(s)
Antibacterianos/efectos adversos , Colistina/efectos adversos , Enfermedades del Prematuro/inducido químicamente , Enfermedades Renales/inducido químicamente , Adulto , Síndrome de Bartter/inducido químicamente , Síndrome de Bartter/diagnóstico , Enterocolitis Necrotizante/tratamiento farmacológico , Femenino , Humanos , Recién Nacido , Recien Nacido Prematuro , Enfermedades del Prematuro/tratamiento farmacológico , Enfermedades Renales/diagnóstico , EmbarazoRESUMEN
Cardiovascular disease is anticipated to remain the leading cause of death globally. Due to the current problems connected with using autologous arteries for bypass surgery, researchers are developing tissue-engineered vascular grafts (TEVGs). The major goal of vascular tissue engineering is to construct prostheses that closely resemble native blood vessels in terms of morphological, mechanical, and biological features so that these scaffolds can satisfy the functional requirements of the native tissue. In this setting, morphology and cellular investigation are usually prioritized, while mechanical qualities are generally addressed superficially. However, producing grafts with good mechanical properties similar to native vessels is crucial for enhancing the clinical performance of vascular grafts, exposing physiological forces, and preventing graft failure caused by intimal hyperplasia, thrombosis, aneurysm, blood leakage, and occlusion. The scaffold's design and composition play a significant role in determining its mechanical characteristics, including suturability, compliance, tensile strength, burst pressure, and blood permeability. Electrospun prostheses offer various models that can be customized to resemble the extracellular matrix. This review aims to provide a comprehensive and comparative review of recent studies on the mechanical properties of fibrous vascular grafts, emphasizing the influence of structural parameters on mechanical behavior. Additionally, this review provides an overview of permeability and cell growth in electrospun membranes for vascular grafts. This work intends to shed light on the design parameters required to maintain the mechanical stability of vascular grafts placed in the body to produce a temporary backbone and to be biodegraded when necessary, allowing an autologous vessel to take its place.
RESUMEN
Membrane fouling is one of the most significant issues to overcome in membrane-based technologies as it causes a decrease in the membrane flux and increases operational costs. This study investigates the effect of common chemical cleaning agents on polymeric nanofibrous membranes (PNM) prepared by polyvinylidene fluoride (PVDF), polyacrylonitrile (PAN), and polyamide 6 (PA6) nanofibers. Common alkaline and acid membrane cleaners were selected as the chemical cleaning agents. Membrane surface morphology was investigated. The PAN PNM were selected and fouled by engine oil and then cleaned by the different chemical cleaning agents at various ratios. The SEM results indicated that the use of chemical agents had some effects on the surface of the nanofibrous membranes. Moreover, alkaline cleaning of the fouled membrane using the Triton X 100 surfactant showed a two to five times higher flux recovery than without using a surfactant. Among the tested chemical agents, the highest flux recovery rate was obtained by a binary solution of 5% sodium hydroxide + Triton for alkaline cleaning, and an individual solution of 1% citric acid for acidic cleaning. The results presented here provide one of the first investigations into the chemical cleaning of nanofiber membranes.
RESUMEN
In order to protect the environment, it is important that oily industrial wastewater is degreased before discharging. Membrane filtration is generally preferred for separation of oily wastewater as it does not require any specialised chemical knowledge, and also for its ease of processing, energy efficiency and low maintenance costs. In the present work, hybrid polyacrylonitrile (PAN) nanofibrous membranes were developed for oily wastewater filtration. Membrane surface modification changed nitrile groups on the surface into carboxylic groups, which improve membrane wettability. Subsequently, TiO2 nanoparticles were grafted onto the modified membranes to increase flux and permeability. Following alkaline treatment (NaOH, KOH) of the hydrolysed PAN nanofibres, membrane water permeability increased two- to eight-fold, while TiO2 grafted membrane permeability increase two- to thirteen-fold, compared to unmodified membranes. TiO2 grafted membranes also displayed amphiphilic properties and a decrease in water contact angle from 78.86° to 0°. Our results indicate that modified PAN nanofibrous membranes represent a promising alternative for oily wastewater filtration.
RESUMEN
Membrane fouling is one of the main drawbacks encountered during the practical application of membrane separation processes. Cleaning of a membrane is important to reduce fouling and improve membrane performance. Accordingly, an effective cleaning method is currently of crucial importance for membrane separation processes in water treatment. To clean the fouling and improve the overall efficiency of membranes, deep research on the cleaning procedures is needed. So far, physical, chemical, or combination techniques have been used for membrane cleaning. In the current work, we critically reviewed the fouling mechanisms affecting factors of fouling such as the size of particle or solute; membrane microstructure; the interactions between membrane, solute, and solvent; and porosity of the membrane and also examined cleaning methods of microfiltration (MF) membranes such as physical cleaning and chemical cleaning. Herein, we mainly focused on the chemical cleaning process. Factors affecting the chemical cleaning performance, including cleaning time, the concentration of chemical cleaning, and temperature of the cleaning process, were discussed in detail. This review is carried out to enable a better understanding of the membrane cleaning process for an effective membrane separation process.
RESUMEN
Chronic wounds are caused by bacterial infections and create major healthcare discomforts; to overcome this issue, wound dressings with antibacterial properties are to be utilized. The requirements of antibacterial wound dressings cannot be fulfilled by traditional wound dressing materials. Hence, to improve and accelerate the process of wound healing, an antibacterial wound dressing is to be designed. Electrospun nanofibers offer a promising solution to the management of wound healing, and numerous options are available to load antibacterial compounds onto the nanofiber webs. This review gives us an overview of some recent advances of electrospun antibacterial nanomaterials used in wound dressings. First, we provide a brief overview of the electrospinning process of nanofibers in wound healing and later discuss electrospun fibers that have incorporated various antimicrobial agents to be used in wound dressings. In addition, we highlight the latest research and patents related to electrospun nanofibers in wound dressing. This review also aims to concentrate on the importance of nanofibers for wound dressing applications and discuss functionalized antibacterial nanofibers in wound dressing.
RESUMEN
Purpose: To report the manifestations, patterns of disease, treatment strategies and outcomes in pediatric patients with noninfectious uveitis.Methods: Demographic information of 76 cases was recorded. Symptoms, anatomic location, laterality, visual acuity (VA), intraocular pressure, associated systemic diseases, therapeutic strategies, side effects, complications were reviewed.Results: Thirty-one patients were diagnosed as uveitis on routine surveillance because of underlying systemic disease. The most common anatomic location was intermediate uveitis (34.2%). Juvenile idiopathic arthritis (JIA) was the most common underlying systemic disease (25%). Glaucoma was the most common complication (7.7%). The patients with refractory uveitis received adalimumab (26.5%), infliximab (4.6%) and tocilizumab (3.1%). The mean first-year VA was between 20/32 and 20/20 in 116/140 eyes.Conclusion: Most pediatric noninfectious uveitis cases have bilateral intermediate uveitis. JIA was the most common systemic association. The first-year VA was good in most eyes which may be due to early use of corticosteroid-sparing agents.
Asunto(s)
Angiografía con Fluoresceína/métodos , Centros de Atención Terciaria , Tomografía de Coherencia Óptica/métodos , Úvea/diagnóstico por imagen , Uveítis/diagnóstico , Agudeza Visual , Niño , Femenino , Estudios de Seguimiento , Fondo de Ojo , Humanos , Incidencia , Masculino , Estudios Retrospectivos , Factores de Tiempo , Turquía/epidemiología , Uveítis/epidemiologíaRESUMEN
Cleaning of wastewater for the environment is an emerging issue for the living organism. The separation of oily wastewater, especially emulsified mixtures, is quite challenged due to a large amount of wastewater produced in daily life. In this review, the membrane technology for oily wastewater treatment is presented. In the first part, the global membrane market, the oil spill accidents and their results are discussed. In the second and third parts, the source of oily wastewater and conventional treatment methods are represented. Among all methods, membrane technology is considered the most efficient method in terms of high separation performance and easy to operation process. In the fourth part, we provide an overview of membrane technology, fouling problem, and how to improve the self-cleaning surface using functional groups for effectively treating oily wastewater. The recent development of surface-modified membranes for oily wastewater separation is investigated. It is believed that this review will promote understanding of membrane technology and the development of surface modification strategies for anti-fouling membranes.
RESUMEN
Nanofibrous materials produced by electrospinning processes have potential advantages in tissue engineering because of their biocompatibility, biodegradability, biomimetic architecture, and excellent mechanical properties. The aim of the current work is to study the influence of the electron beam on the poly L-lactide acid/ carboxy-methyl starch/ß-tricalcium phosphate (PLLA/CMS/ß-TCP) composite nanofibers for potential applications as bone-tissue scaffolds. The composite nanofibers were prepared by electrospinning in the combination of 5% v/v carboxy-methyl starch (CMS) and 0.25 wt% of ß-TCP with the PLLA as a matrix component. The composites nanofibers were exposed under 5, 30, and 100 kGy of irradiation dose. The electron-beam irradiation showed no morphological damage to the fibers, and slight reduction in the water-contact angle and mechanical strength at the higher-irradiation doses. The chain scission was found to be a dominant effect; the higher doses of electron-beam irradiation thus increased the in vitro degradation rate of the composite nanofibers. The chemical interaction due to irradiation was indicated by the Fourier transform infrared (FTIR) spectrum and thermal behavior was investigated by a differential scanning calorimeter (DSC). The results showed that the electron-beam-induced poly L-lactide acid/carboxy-methyl starch/ß-tricalcium phosphate (PLLA/CMS/ß-TCP) composite nanofibers may have great potential for bone-tissue engineering.
RESUMEN
Novel electrospun polyacrylonitrile (PAN) nanofibrous membranes were prepared by using heat-press lamination under various conditions. The air permeability and the burst-pressure tests were run to select the membranes for point-of-use air and water cleaning. Membrane characterization was performed by using scanning electron microscopy, contact angle, and average pore size measurements. Selected membranes were used for both air dust filtration and cross-flow water filtration tests. Air dust filter results indicated that electrospun PAN nanofibrous membranes showed very high air-dust filtration efficiency of more than 99.99 % in between PM0.3 and PM2.5, whereas cross-flow filtration test showed very high water permeability over 600â L/(m2hbar) after 6â h of operation. Combining their excellent efficiency and water permeability, these membranes offer an ideal solution to filter both air and water pollutants.
RESUMEN
Preparing easily scaled up, cost-effective, and recyclable membranes for separation technology is challenging. In the present study, a unique and new type of modified polyvinylidene fluoride (PVDF) nanofibrous membrane was prepared for the separation of oil-water emulsions. Surface modification was done in two steps. In the first step, dehydrofluorination of PVDF membranes was done using an alkaline solution. After the first step, oil removal and permeability of the membranes were dramatically improved. In the second step, TiO2 nanoparticles were grafted onto the surface of the membranes. After adding TiO2 nanoparticles, membranes exhibited outstanding anti-fouling and self-cleaning performance. The as-prepared membranes can be of great use in new green separation technology and have great potential to deal with the separation of oil-water emulsions in the near future.
RESUMEN
In the present study, PCL (polycaprolactone) nanofibres were produced by the electrospinning method. The use of PCL electrospun biopolymer in biomedical applications has attracted considerable interest due to its chemical resistance, biodegradability, biocompatibility, and non-toxic characteristics. However, the hydrophobic nature of PCL polymer restricts the useage of PCL nanofibres for the cell adhesion and absorption. A hydrophilic and biocompatible PCL electrospun mat with a low water contact angle is an attractive strategy for development in tissue engineering and wound dressing. In this study, we demonstrate a feasible and simple method to produce hydrophilic PCL nanofibres for possible application in wound dressing. Chloroform/ethanol (EtOH) and chloroform/dimethylformamide (DMF) mixtures were used as two different solvent systems. The impact of the polymeric solution concentration, applied voltage, and solvent mixtures on the fibre surface morphology and water contact angle was investigated. Consequently, bead structures were observed at low concentrations but disappeared with increases in the concentration. It was observed that the size of beads decreased and the diameter of fibres increased with increasing voltage. The wettability of the webs changed from hydrophobic to hydrophilic with changes of the polymer concentration. The contact angle of the nanofibre mats decreased in both solvent systems as the concentration increased. The results showed that the lowest contact angle was obtained in 24% wt. PCL+chloroform/EtOH solution and was 68°. The highest contact angle was obtained in 4% wt. PCL+chloroform/EtOH solution and was 112°. Using this method, the surface hydrophilicity of the PCL nanofibres improved easily without any surface treatment.
RESUMEN
A natural polymer of carboxymethyl starch (CMS) was used in combination with the inorganic mineral of ß-Tricalcium Phosphate (ß-TCP) and Poly l-lactide (PLLA) to prepare composite nanofibers with the potential to be used as a biomedical membrane. ß-TCP contents varied in the range of 0.25% to 1% in the composition of PLLA and CMS. A mixed composition of these organic and inorganic materials was electro-spun to produce composite nanofibers. Morphological investigation indicated that smooth and uniform nanofibers could be produced via this technique. The average of the nanofiber diameters was slightly increased from 190 to 265 nm with the ß-TCP content but some agglomeration of particles began to impede in the fiber at a higher content of ß-TCP. It was observed that the fibers were damaged at a higher content of ß-TCP nanoparticles. With the presence of higher ß-TCP, the wettability of the PLLA was also improved, as indicated by the water contact angle measurement from 127.3° to 118°. The crystallization in the composite decreased, as shown in the changes in glass transition (Tg) and melting temperature (Tm) by differential scanning calorimeter (DSC) and X-ray diffraction analysis. Increases in ß-TCP contributed to weaker mechanical strength, from 8.5 to 5.7 MPa, due to imperfect fiber structure.
RESUMEN
Membranes are considered as a promising technology for separation and filtration processes. Here, novel polyvinylidene fluoride (PVDF) nanofibrous multilayer membranes were fabricated by wire-based industrial electrospinning equipment following by a lamination process. The lamination process was optimised under various applied temperature, force of lamination, and lamination time. Air permeability and burst-pressure tests were run to determine the optimum membranes for filtration application. The structures of the prepared membranes were characterised by scanning electron microscopy and pore-size analysis. The hydrophilic properties of the membranes were evaluated using water contact angle measurement, and the mechanical strength of the membranes was analysed. Air and water filtration tests were run to find the possible application of prepared membranes. The air filtration results showed that membranes had high filtration efficiencies: Over 99.00% for PM2.5, and PM0.1. The water filtration results indicated that permeability of the membranes changed from 288 to 3275 L/m²hbar. The successful preparation of such an interesting material may provide a new approach for the design and development of electrospun filter membranes.
RESUMEN
In the new century, electrospun nanofibrous webs are widely employed in various applications due to their specific surface area and porous structure with narrow pore size. The mechanical properties have a major influence on the applications of nanofiber webs. Lamination technology is an important method for improving the mechanical strength of nanofiber webs. In this study, the influence of laminating pressure on the properties of polyacrylonitrile (PAN) and polyvinylidene fluoride (PVDF) nanofibers/laminate was investigated. Heat-press lamination was carried out at three different pressures, and the surface morphologies of the multilayer nanofibrous membranes were observed under an optical microscope. In addition, air permeability, water filtration, and contact angle experiments were performed to examine the effect of laminating pressure on the breathability, water permeability and surface wettability of multilayer nanofibrous membranes. A bursting strength test was developed and applied to measure the maximum bursting pressure of the nanofibers from the laminated surface. A water filtration test was performed using a cross-flow unit. Based on the results of the tests, the optimum laminating pressure was determined for both PAN and PVDF multilayer nanofibrous membranes to prepare suitable microfilters for liquid filtration.