Bioactive compounds from Cudrania tricuspidata: A natural anticancer source.

The tumor is becoming a critical threat to our lives in these years. Searching for antitumor substances from natural products is a great interest of scientists. Cudrania tricuspidata (C. tricuspidata) is a regional plant containing 158 flavonoids and 99 xanthones, and others ingredients with favorable bioactivity. This review comprehensively analyzes the antitumor compounds from C. tricuspidata against different tumors, and 78 flavonoids plus xanthones are considered as underlying antineoplastic. Importantly, the structure of preylation groups is the primary source of antitumor activity among 45 flavonoids plus xanthones, which could be a direction of structural modification for a better antitumor ability. Additionally, the fruits are also preferable sources of antitumor compounds compared to the roots and barks due to the abundant isoflavones and sustainability. However, many studies only focused on the cells viability inhibition of the compounds, the underlying molecular mechanisms, and the intracellular targets remain ambiguous. In conclusion, C. tricuspidata has a great potential for anti-tumor prevention or therapy, but more attention should be paid to deeper research in vitro and in vivo models.

Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.

Cadmium (Cd) is an environmental contaminant found in soil, water, and food, and can cause oxidative stress and male reproductive damage. During puberty, the male reproductive system is very vulnerable to interference, however, the dysregulation of Cd on spermatogenesis in this period is ambiguous. The anthocyanin cyanidin-3-O-glucoside (C3G) is phytochemical rich in plants and fruits and has been shown to have remarkable anti-oxidant activity, making it an ideal nutrient for nutritional intervention. By modeling Cd-induced damage in male pubertal mice and feeding with C3G, we demonstrated that the C3G could rescue the amount and activity of sperm predominantly. Furthermore, C3G showed partial resistance to Cd-induced histone modification during spermiogenesis and prevented oxidative damage of the DNA in the sperm nucleus. Additionally, C3G mitigated the oxidative stress of testis to achieve the level coinciding with the control group. Meanwhile, Cd-induced mitochondrial apoptosis of sperm cells was reduced significantly via the MAPK signaling pathway in the presence of C3G. Collectively, our findings can offer a potential intervention for combating Cd-induced reproductive damage during puberty by taking anthocyanin as a dietary supplement.