Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 27
Filtrar
Más filtros

Banco de datos
Tipo del documento
País de afiliación
Intervalo de año de publicación
1.
Kyobu Geka ; 65(3): 255-7, 2012 Mar.
Artículo en Japonés | MEDLINE | ID: mdl-22374606

RESUMEN

We report 2 cases of lung cancer incidentally detected following pneumothorax. Case 1:A 40-year-old man complaining of dyspnea was admitted with right pneumothorax. Chest computed tomography (CT) after chest drainage showed a cavitary nodule with pleural indentations in the right lower lobe. It was indicated at surgery that pneumothorax was caused by perforation of the tumor into the pleural cavity. Right lower lobectomy was performed because the pathological diagnosis of the nodule was a large cell carcinoma. The final histopathological diagnosis was stage II A (pT2aN1M0). The patient died of recurrence 14 months after surgery. Case 2:A 47-year-old man who admitted with right pneumothorax was found to have a nodule with pleural indentations closely a bulla at the apex of the right lung by chest CT after chest drainage. Pneumothorax was indicated to be caused by rupture of the bulla at surgery. Right upper lobectomy was performed because the pathological diagnosis of the nodule was a squamous carcinoma. The final histopathological diagnosis was stage I A (pT1bN0M0). The patient is alive at 2 years after the operation without recurrence. Lung cancer detected following pneumothorax which was caused by perforation of the tumor is generally considered to have poor prognosis. Whereas, prognosis of lung cancer incidentally detected following pneumothorax depends on its staging.


Asunto(s)
Carcinoma de Células Grandes/diagnóstico , Carcinoma de Células Escamosas/diagnóstico , Neoplasias Pulmonares/diagnóstico , Neumotórax/complicaciones , Adulto , Carcinoma de Células Grandes/complicaciones , Carcinoma de Células Escamosas/complicaciones , Humanos , Hallazgos Incidentales , Neoplasias Pulmonares/complicaciones , Masculino , Persona de Mediana Edad
2.
Kyobu Geka ; 64(2): 173-5, 2011 Feb.
Artículo en Japonés | MEDLINE | ID: mdl-21387628

RESUMEN

A 76-year-old female was admitted to our hospital because of an abnormal shadow on chest computed tomography (CT) which showed the tumor extending from left lower end of the thyroid to the aortic window along the left side of the trachea, indicating the retrosternal goiter. Serum thyroid stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were within normal ranges. The tumor was resected through cervical collar incision and median sternotomy. The pathological diagnosis was an adenomatous goiter. The patient was discharged without complications.


Asunto(s)
Bocio/diagnóstico , Enfermedades del Mediastino/diagnóstico , Anciano , Femenino , Humanos
3.
Kyobu Geka ; 63(13): 1181-3, 2010 Dec.
Artículo en Japonés | MEDLINE | ID: mdl-21174672

RESUMEN

A 39-year-old woman was referred to our hospital because of pneumothorax related to menstruation. Chest X-ray showed right pneumothorax. Right thoracoscopy revealed 3 fenestrations on the diaphragm. Partial resection of the diaphragm including these lesions were performed. Intrathoracic minocycline was applied expecting pleural adhesion after surgery. Histopathological examination confirmed the presence of endometriosis on the resected diaphragm.


Asunto(s)
Neumotórax , Adulto , Diafragma/patología , Diafragma/cirugía , Femenino , Humanos , Neumotórax/diagnóstico , Neumotórax/cirugía
4.
Ophthalmology ; 116(1): 130-4, 2009 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-19019445

RESUMEN

PURPOSE: Hematic cysts of the orbit are relatively uncommon. These cysts expand gradually, leading to progressive orbital symptoms. To clarify the cause of hematic cyst, especially the mechanisms leading to its gradual expansion, we investigated the immunohistologic expression of tissue-type plasminogen activator (tPA), a key enzyme of fibrinolysis, in cases of hematic cysts. DESIGN: Retrospective small case series. PARTICIPANTS: Three patients with hematic cyst of the orbit were studied. METHODS: Three surgically removed hematic cysts were studied from a histologic perspective, including immunohistochemistry for tPA. The cyst content was also analyzed chemically. MAIN OUTCOME MEASURES: The pathologic features of hematic cyst of the orbit, expression of tPA in the cyst wall, and coagulation-fibrinolytic factors in the content of the cyst. RESULTS: The cyst wall was composed of dense collagen fibers lacking an epithelial lining and contained many fine capillary- or venule-like vessels. Hemosiderin-laden macrophages were observed among the collagen fibers. Strong immunoreactivity for tPA was revealed in the endothelial cells of the vessels in the cyst wall. Chemical analysis of the cyst content revealed a marked delay in the activated partial thromboplastin time and prothrombin time, a low fibrinogen concentration, and high concentrations of the D-dimer and tPA-plasminogen activator inhibitor-1 complex. CONCLUSIONS: Our findings indicate that blood coagulation and hemostasis occur first and that fibrinolysis occurs second in hematic cysts. Gradual expansion of the cyst may be due to hyperfibrinolysis resulting from oversecretion of tPA from the endothelial cells in the cyst wall, thus impairing normal hemostasis. Hemorrhage may then recur, resulting in enlargement of the hematic cyst. These mechanisms are similar to those occurring in chronic subdural hematomas. FINANCIAL DISCLOSURE(S): The author(s) have no proprietary or commercial interest in any materials discussed in this article.


Asunto(s)
Quistes/etiología , Fibrinólisis , Fibrinolíticos/metabolismo , Hematoma/etiología , Enfermedades Orbitales/etiología , Activador de Tejido Plasminógeno/metabolismo , Anciano , Quistes/diagnóstico , Quistes/metabolismo , Endotelio Vascular/metabolismo , Femenino , Hematoma/diagnóstico , Hematoma/metabolismo , Humanos , Técnicas para Inmunoenzimas , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Enfermedades Orbitales/diagnóstico , Enfermedades Orbitales/metabolismo , Tiempo de Tromboplastina Parcial , Inhibidor 1 de Activador Plasminogénico/análisis , Tiempo de Protrombina , Estudios Retrospectivos , Tomografía Computarizada por Rayos X
5.
J Neurosurg ; 111(3): 504-8, 2009 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-19249956

RESUMEN

The authors present a very rare case of benign fibrous histiocytoma of the skull with increased intracranial pressure caused by sinus occlusion. A 33-year-old woman was referred for investigation of a right occipital protrusion with tenderness and double vision. She had only mild divergence insufficiency and bilateral papilledema neurologically. Imaging findings showed that the skull tumor was located at the right occipital bone with bone disruption and a compressed right sigmoid sinus. When planning the resection, caution was required to spare the collateral flow so as to manage the intracranial pressure. Immunohistochemical analysis showed that the tumor was positive for CD68, alpha1-antichymotrypsin, and alpha1-antitrypsin. From these findings, the tumor was diagnosed as a primary benign fibrous histiocytoma of the skull.


Asunto(s)
Senos Craneales , Histiocitoma Fibroso Benigno/fisiopatología , Presión Intracraneal , Neoplasias Craneales/fisiopatología , Adulto , Circulación Cerebrovascular , Femenino , Histiocitoma Fibroso Benigno/diagnóstico , Humanos , Neoplasias Craneales/diagnóstico , Tomografía Computarizada por Rayos X
6.
J Neurosurg ; 106(4): 638-45, 2007 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-17432716

RESUMEN

OBJECT: The receptor for hyaluronan-mediated motility (RHAMM) is frequently overexpressed in brain tumors and was recently identified as an immunogenic antigen by using serological screening of cDNA expression libraries. In this study, which was conducted using a mouse glioma model, the authors tested the hypothesis that vaccination with dendritic cells transfected with RHAMM mRNA induces strong immunological antitumor effects. METHODS: The authors constructed a plasmid for transduction of the mRNAs transcribed in vitro into dendritic cells, which were then used to transport the intracellular protein RHAMM efficiently into major histocompatibility complex class II compartments by adding a late endosomal-lysosomal sorting signal to the RHAMM gene. The dendritic cells transfected with this RHAMM mRNA were injected intraperitoneally into the mouse glioma model 3 and 10 days after tumor cell implantation. The antitumor effects of the vaccine were estimated by the survival rate, histological analysis, and immunohistochemical findings for immune cells. Mice in the group treated by vaccination therapy with dendritic cells transfected with RHAMM mRNA survived significantly longer than those in the control groups. Immunohistochemical analysis revealed that greater numbers of T lymphocytes containing T cells activated by CD4+, CD8+, and CD25+ were found in the group vaccinated with dendritic cells transfected with RHAMM mRNA. CONCLUSIONS: These results demonstrate the therapeutic potential of vaccination with dendritic cells transfected with RHAMM mRNA for the treatment of malignant glioma.


Asunto(s)
Neoplasias Encefálicas/terapia , Vacunas contra el Cáncer/uso terapéutico , Proteínas de la Matriz Extracelular/genética , Proteínas de la Matriz Extracelular/uso terapéutico , Glioma/terapia , Receptores de Hialuranos/genética , Receptores de Hialuranos/uso terapéutico , Transfección , Animales , Células Dendríticas/fisiología , Modelos Animales de Enfermedad , Genes MHC Clase II , Masculino , Ratones , Ratones Endogámicos C57BL , Transporte de ARN/fisiología , ARN Mensajero/fisiología
7.
No Shinkei Geka ; 35(5): 475-9, 2007 May.
Artículo en Japonés | MEDLINE | ID: mdl-17491343

RESUMEN

A 72-year-old female presented with a lump in the left superior-lateral eyelid. The magnetic resonance imaging showed a well-delineated mass in the left lacrimal gland. The tumor was isointense on both the T1 and T2 weighted images, and it was homogenously enhanced with Gd-DTPA. Surgery via the trans-cranial approach revealed a pinkish and elastic-hard tumor. Total resection was successfully performed. The hematoxilyn-eosin staining of the surgical specimen showed a dense infiltrate of lymphocytes, which were composed predominantly of small lymphocytes, centrocyte-like cells, monocytoid cells, and occasionally transformed lymphocytes. The immunohistochemical findings for CD20, CD3, UCHL-1, CD23, CD5, cyclinD1, and bcl-2 were compatible with Mucosa Associated Lymphoid Tissue (MALT)-type lymphoma. The patient received local radiation therapy (30 Gy/15 fractions). She remained in complete clinical remission of the disease about one and a half years after treatment.


Asunto(s)
Neoplasias del Ojo/diagnóstico , Aparato Lagrimal , Linfoma de Células B de la Zona Marginal/diagnóstico , Anciano , Neoplasias del Ojo/radioterapia , Femenino , Gadolinio DTPA , Humanos , Linfoma de Células B de la Zona Marginal/radioterapia , Imagen por Resonancia Magnética , Dosificación Radioterapéutica , Inducción de Remisión
8.
J Neurosurg ; 126(1): 274-280, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27035176

RESUMEN

OBJECTIVE To avoid ischemic complications, it is important to consider the arteries in resection planning for lesions such as a vascular intraparenchymal tumor and arteriovenous malformation. Here, the clinical application of laser speckle flow imaging (LSFI) as a complementary method for the management of mass lesion-related arteries during surgery was evaluated. METHODS LSFI was performed in 12 patients with mass lesion-related arteries and brain tumor or arteriovenous malformation. The portable LSFI device was centered over the surgical field, and the relative cerebral blood flow (CBF) before and after the temporary interruption of the arteries was measured through continuous recording. CBF fluctuations permitted the classification of 3 kinds of artery-a feeding artery (FA), a "passing through" artery (PA), and a combined FA and PA (FA+PA)-based on decreased relative CBF in the inner resection area and unchanged CBF in the surrounding area (FA), unchanged CBF in the inner area and decreased CBF in the surrounding area (PA), or decreased CBF in both areas (FA+PA). This information allowed the appropriate management of these arteries and avoidance of postoperative ischemic complications. RESULTS Good visualization of CBF in the surgical field and relative CBF measurements in the regions of interest were achieved in real time with excellent spatiotemporal resolution. In 11 patients (92%) and 20 regions of interest, a decline in CBF was observed after temporary interruption of the FA (n = 8), PA (n = 2), and FA+PA (n = 2) types. There was a significant average reduction in CBF of 15.3% ± 29.0%. There were no ischemic complications, and only 1 patient had a postoperative ischemic lesion caused by resection through an artery that could not be viewed by LSFI due to a positional problem. CONCLUSIONS LSFI permits noninvasive and rapid intraoperative real-time recognition of mass lesion-related vasculature. This information can be used to avoid ischemic complications as a procedure complementary to neurophysiological monitoring.


Asunto(s)
Isquemia Encefálica/prevención & control , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/cirugía , Angiografía Cerebral , Imagen Óptica , Complicaciones Posoperatorias/prevención & control , Adulto , Anciano , Arterias/diagnóstico por imagen , Encéfalo/irrigación sanguínea , Encéfalo/diagnóstico por imagen , Encéfalo/cirugía , Isquemia Encefálica/diagnóstico por imagen , Neoplasias Encefálicas/irrigación sanguínea , Angiografía Cerebral/métodos , Circulación Cerebrovascular , Niño , Preescolar , Femenino , Humanos , Rayos Láser , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/diagnóstico por imagen
9.
Ann Thorac Surg ; 73(4): 1055-8; discussion 1058-9, 2002 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-11996240

RESUMEN

BACKGROUND: Minimal resection of small lung tumors is still controversial. This study was conducted to clarify whether this type of operation is acceptable. METHODS: From January 1992 to December 1994, 73 patients were registered in a multiinstitutional trial of limited resection for peripheral lung tumors less than 2 cm in diameter. The operative procedure consisted of extended segmentectomy in which the cut line of the lung was beyond the burdened segment, confirming N0 disease by intraoperative lymph node examination of frozen sections. The operation was changed to other procedures if the report was positive. RESULTS: All the patients were observed more than 5 years. There were no perioperative deaths and no major complications. A total of 55 patients were finally enrolled in this study. Ten patients died postoperatively, 4 of lung cancer and the remaining 6 died of other diseases, with no signs of recurrence. The 5-year survival rate, excluding these 6 patients, was 91.8%; for all patients including those who died it was 81.8%. A total of 18 patients were not included in this study for various reasons. The decrease in forced vital capacity was 11.3% +/- 9.8% compared with the preoperative value. CONCLUSIONS: Extended segmentectomy is an alternative method as a standard operation for patients with small peripheral lung tumors, and the loss of lung function is minimal. However, patient selection must be strict, with intraoperative pathologic examination, and a wide margin to the lesion beyond the burdened segment is mandatory.


Asunto(s)
Neoplasias Pulmonares/cirugía , Neumonectomía/métodos , Adenocarcinoma/mortalidad , Adenocarcinoma/patología , Adenocarcinoma/cirugía , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/patología , Carcinoma de Células Escamosas/cirugía , Femenino , Humanos , Neoplasias Pulmonares/mortalidad , Neoplasias Pulmonares/patología , Masculino , Persona de Mediana Edad , Tasa de Supervivencia
10.
Neurosurgery ; 54(1): 182-9; discussion 189-90, 2004 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-14683556

RESUMEN

OBJECTIVE: In a syngeneic mouse brain tumor model, we tested the hypothesis that vaccination with tumor cells genetically modified to express B7.1 molecules induces tumor-specific T cells and immunological antitumor effects. METHODS: Malignant glioma cells (RSV-MG) derived from a C3H/He mouse induced by Schmidt-Ruppin Rous sarcoma virus (RSV) were infected with an adenovirus encoding the B7.1 gene (AdB7). To investigate the effects of B7.1 expression on the tumorigenicity of RSV-MG cells, infected cells were implanted subcutaneously into C3H/He mice. The C3H/He mice were vaccinated with AdB7 transfectants injected subcutaneously and 2 weeks later were challenged intracerebrally with wild-type RSV-MG cells to determine whether or not the expression of B7.1 would enhance the immunogenicity of RSV-MG cells. RESULTS: Immunocytochemistry confirmed the expression of B7.1 and major histocompatibility complex Class I antigen on the infected cells. The growth of subcutaneous tumors was markedly retarded in the AdB7 group, whereas tumors had formed and progressively increased in size in the other control groups. In the vaccine experiments, the mice immunized with AdB7 transfectants survived longer than did the mice of the other groups, and a significant difference in survival times was noted. Immunocytochemistry revealed that brain tumors in mice previously vaccinated with AdB7 infectants had been infiltrated by a larger number of CD3(+) lymphocytes and that these CD3(+) lymphocytes contained not only CD4(+) and CD8(+) T cells but also CD25(+)-activated T cells. In addition, a cytotoxicity assay confirmed that vaccination with the AdB7 transfectants induced tumor-specific cytotoxicity. CONCLUSION: These results demonstrate the therapeutic potential of vaccination with tumor cells expressing B7.1 for the treatment of malignant glioma.


Asunto(s)
Antígeno B7-1/administración & dosificación , Antígeno B7-1/genética , Neoplasias Encefálicas/tratamiento farmacológico , Técnicas de Transferencia de Gen , Glioma/tratamiento farmacológico , Inmunoterapia Activa/métodos , Adenoviridae , Animales , Virus del Sarcoma Aviar , Neoplasias Encefálicas/virología , Línea Celular Tumoral , Modelos Animales de Enfermedad , Expresión Génica , Vectores Genéticos , Glioma/virología , Ratones , Ratones Endogámicos C3H
11.
Neurol Med Chir (Tokyo) ; 43(11): 534-40, 2003 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-14705319

RESUMEN

The characteristics of seizures associated with parietal lobe epilepsy were investigated in six consecutive patients with medically intractable epilepsy due to parietal lobe lesions. Intracranial electrode recordings were retrospectively reviewed to investigate the seizure onset symptoms and spreading patterns associated with the disorder. All six patients underwent implantation of subdural or depth electrodes and subsequent video/electroencephalography monitoring. Common symptoms included motionless stare, contralateral eye deviation, and head turn. Tonic posturing, contralateral sensory disturbance, and motor weakness were also seen. Asymmetrical generalized tonic and clonic seizures were seen in all six patients. All seizure activities began in the parietal lobe harboring the lesions, and then spread immediately to the adjacent lobes in most seizures, where the clinical symptoms were produced. The parietal lobe is a pure generator of seizures, whereas most clinical symptoms originate from adjacent lobes following seizure onset. No apparent specific symptoms other than sensory disturbance arising from the parietal lobe proper were recognized. Regardless of clinical symptoms, the seizure onset occurred in the parietal lobe harboring the lesion.


Asunto(s)
Electroencefalografía , Epilepsia/fisiopatología , Lóbulo Parietal/fisiopatología , Adulto , Niño , Femenino , Humanos , Masculino
13.
No Shinkei Geka ; 32(1): 49-54, 2004 Jan.
Artículo en Japonés | MEDLINE | ID: mdl-14978924

RESUMEN

Recent progress in diagnostic imaging techniques, such as MRI and CT, has shown that Rathke's cleft cyst is more common than once thought. However, few cases have been reported in which a cerebral arterial aneurysm was merged with a symptomatic Rathke's cleft cyst. We present a case of bilateral internal carotid aneurysms associated with a symptomatic giant Rathke's cleft cyst. A 66-year-old-woman with a visual disturbance was admitted to our hospital. CT and MRI showed a large mass in the frontal base to the suprasellar region. The mass showed isosignal intensity in T1-weighted images (WI), a ringed enhancement with Gd-DTPA, and hyperintensity in T2WI. An angiography showed bilateral A1 elevation but no tumor stain. In addition, unruptured aneurysms appeared in the inside back C2 portion of the bilateral internal carotid arteries. For these lesions, a bifrontal craniotomy was performed. In a single operative approach, the mass lesion was removed and the aneurysms were successfully clipped. The aneurysms adhered strongly to the wall of the mass. The histological diagnosis of the mass was Rathke's cleft cyst. A precise pre-operative understanding of the anatomical structure and a careful operative procedure are important for the treatment of these complex lesions.


Asunto(s)
Aneurisma/complicaciones , Aneurisma/cirugía , Enfermedades de las Arterias Carótidas/complicaciones , Enfermedades de las Arterias Carótidas/cirugía , Arteria Carótida Interna , Quistes del Sistema Nervioso Central/complicaciones , Quistes del Sistema Nervioso Central/cirugía , Anciano , Aneurisma/diagnóstico , Enfermedades de las Arterias Carótidas/diagnóstico , Quistes del Sistema Nervioso Central/diagnóstico , Femenino , Humanos , Imagen por Resonancia Magnética , Procedimientos Neuroquirúrgicos , Tomografía Computarizada por Rayos X , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares , Trastornos de la Visión/etiología
14.
Brain Tumor Pathol ; 31(2): 77-84, 2014 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-23670138

RESUMEN

Glioma stem cells (GSCs) may be a source of tumor progression and recurrence after multimodal therapy, because of their high invasive potential. The purpose of this study was to compare the invasive and migratory properties of GSCs and non-GSCs and examine the distribution of these cells in a mouse xenograft model. Three GSC lines, G144, Y02, and Y10, cultured from human glioblastoma, were used in the study. Matrigel-invasion assays of infiltration and time-lapse studies of migration were performed for comparison of the GSCs with the corresponding differentiated non-GSC lines. Cells were also transplanted into mouse brain and the different distribution of GSCs and non-GSCs was examined in the tumor xenograft model. All 3 GSC lines had greater invasion and migration ability than the corresponding non-GSCs. In vivo, GSCs infiltrated more widely than non-GSCs and reached the contralateral hemisphere via the corpus callosum in the early stage of tumorigenesis. GSCs also primarily penetrated the subventricular zone (SVZ). GSCs have high invasive potential and tend to be present in the outer tumor bulk and infiltrate the contralateral hemisphere via the corpus callosum, in addition to penetrating the SVZ.


Asunto(s)
Neoplasias Encefálicas/patología , Glioma/patología , Células Madre Neoplásicas/patología , Animales , Línea Celular Tumoral , Movimiento Celular , Cuerpo Calloso/patología , Modelos Animales de Enfermedad , Xenoinjertos , Humanos , Ventrículos Laterales/patología , Ratones Endogámicos NOD , Ratones SCID , Invasividad Neoplásica , Trasplante de Neoplasias
15.
Int J Oncol ; 45(5): 1857-66, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-25118635

RESUMEN

Cancer stem cells (CSCs) have been studied for their self-renewal capacity and pluripotency, as well as their resistance to anticancer therapy and their ability to metastasize to distant organs. CSCs are difficult to study because their population is quite low in tumor specimens. To overcome this problem, we established a culture method to induce a pancreatic cancer stem-like cell (P-CSLC)-enriched population from human pancreatic cancer cell lines. Human pancreatic cancer cell lines established at our department were cultured in CSC-inducing media containing epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), leukemia inhibitory factor (LIF), neural cell survivor factor-1 (NSF-1), and N-acetylcysteine. Sphere cells were obtained and then transferred to a laminin-coated dish and cultured for approximately two months. The surface markers, gene expression, aldehyde dehydrogenase (ALDH) activity, cell cycle, and tumorigenicity of these induced cells were examined for their stem cell-like characteristics. The population of these induced cells expanded within a few months. The ratio of CD24high, CD44high, epithelial specific antigen (ESA) high, and CD44variant (CD44v) high cells in the induced cells was greatly enriched. The induced cells stayed in the G0/G1 phase and demonstrated mesenchymal and stemness properties. The induced cells had high tumorigenic potential. Thus, we established a culture method to induce a P-CSLC-enriched population from human pancreatic cancer cell lines. The CSLC population was enriched approximately 100-fold with this method. Our culture method may contribute to the precise analysis of CSCs and thus support the establishment of CSC-targeting therapy.


Asunto(s)
Medios de Cultivo/farmacología , Péptidos y Proteínas de Señalización Intercelular/metabolismo , Células Madre Neoplásicas/efectos de los fármacos , Neoplasias Pancreáticas/patología , Línea Celular Tumoral , Transición Epitelial-Mesenquimal/efectos de los fármacos , Citometría de Flujo , Humanos , Péptidos y Proteínas de Señalización Intercelular/química , Células-Madre Neurales/efectos de los fármacos , Células-Madre Neurales/patología , Neoplasias Pancreáticas/genética , Neoplasias Pancreáticas/terapia , Neoplasias Pancreáticas
16.
Neurol Med Chir (Tokyo) ; 53(10): 655-62, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-24077276

RESUMEN

Abnormal hemodynamics during extirpation of a para-medulla oblongata (MO) tumor is common and may be associated with direct vagal stimulation of the medullary circuit. However, resection of tumors on the dorsal MO may also induce hemodynamic instability without direct vagal stimulus. The objective of this study was to examine the characteristics of hemodynamic instability unrelated to vagal stimulus during dissection of an intra-fourth ventricular tumor with attachment to the dorsal MO. A retrospective analysis was performed in 13 patients. Abnormal hemodynamics were defined as a > 20% change from the means of the intraoperative mean arterial pressure (MAP) and heart rate (HR). Relationships of intraoperative hemodynamics were evaluated with various parameters, including the volume of the MO. Six patients (46.2%) had intraoperative hypertension during separation of the tumor bulk from the dorsal MO. The maximum MAP and HR in these patients were significantly greater than those in patients with normal hemodynamics (116.0 ± 18.0 mmHg versus 85.6 ± 6.5 mmHg; 124.3 ± 22.8 bpm versus 90.5 ± 14.7 bpm). All six cases with abnormal hemodynamics showed hemodynamic fluctuation during separation of the tumor bulk from the dorsal MO. The preoperative volume of the MO in these patients was 1.11 cc less than that in patients with normal hemodynamics, but the volume after tumor resection was similar in the two groups (5.23 cc and 5.12 cc). This suggests that the MO was compressed by the conglutinate tumor bulk, with resultant fluctuation of hemodynamics. Recognition of and preparation for this phenomenon are important for surgery on a tumor located on the dorsal MO.


Asunto(s)
Bradicardia/etiología , Neoplasias del Ventrículo Cerebral/cirugía , Hemodinámica , Hipertensión/etiología , Hipotensión/etiología , Neoplasias Infratentoriales/cirugía , Complicaciones Intraoperatorias/etiología , Bulbo Raquídeo/cirugía , Taquicardia/etiología , Adolescente , Adulto , Astrocitoma/cirugía , Bradicardia/fisiopatología , Niño , Preescolar , Craneotomía , Ependimoma/cirugía , Femenino , Cuarto Ventrículo , Hemangioblastoma/cirugía , Humanos , Hipertensión/fisiopatología , Hipotensión/fisiopatología , Complicaciones Intraoperatorias/fisiopatología , Masculino , Bulbo Raquídeo/patología , Tamaño de los Órganos , Papiloma del Plexo Coroideo/cirugía , Estudios Retrospectivos , Taquicardia/fisiopatología , Nervio Vago/fisiopatología , Adulto Joven
17.
Brain Tumor Pathol ; 30(4): 247-52, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23306965

RESUMEN

We report a case of intracranial yolk sac tumor in a 17-year-old girl with Down syndrome who presented with left slowly progressive hemiparesis. Initial magnetic resonance imaging (MRI) showed a small area of ill-defined abnormal signal intensity without a mass in the bilateral basal ganglia. These findings progressed very slowly for 2 years, but then the lesion rapidly progressed to a huge mass on MRI 4 months after the previous scan. The patient subsequently underwent a blood examination and endoscopic biopsy, and was finally diagnosed with yolk sac tumor. Standard platinum-based chemotherapy and radiotherapy were performed as soon as practicable. The frequency of solid cancer in patients with Down syndrome is generally lower than that in individuals without this disorder. Brain tumor is also rare in Down syndrome, but half of these cases are germ cell tumors. Moreover, slowly progressive non-tumor-like lesions in the basal ganglia may also be germ cell tumors. Therefore, MRI signal abnormalities in the basal ganglia in patients with Down syndrome require careful and frequent follow-up scans based on the possibility of a germ cell tumor that may exhibit rapid growth.


Asunto(s)
Ganglios Basales , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/terapia , Síndrome de Down/complicaciones , Tumor del Seno Endodérmico/diagnóstico , Tumor del Seno Endodérmico/terapia , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias Encefálicas/patología , Quimioradioterapia , Cisplatino/administración & dosificación , Progresión de la Enfermedad , Tumor del Seno Endodérmico/patología , Etopósido/administración & dosificación , Femenino , Humanos , Ifosfamida/administración & dosificación , Imagen por Resonancia Magnética , Paresia/etiología , Resultado del Tratamiento
18.
J Neurosurg Pediatr ; 7(6): 604-8, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21631196

RESUMEN

The authors report a rare case of intracranial yolk sac tumor in a 13-year-old boy with Down syndrome who presented with left hemiparesis. Admission MR imaging revealed a tumor in the right basal ganglia. Serum α-fetoprotein was markedly elevated. Yolk sac tumor was diagnosed radiologically and serologically. The standard therapy for intracranial yolk sac tumor is platinum-based chemotherapy with concomitant radiotherapy. However, the authors used reduced-dose chemotherapy and asynchronized radiotherapy because of the well-known low tolerance of patients with Down syndrome to chemotherapy. This treatment was successful with no complications. Blood cancers are frequently associated with Down syndrome, whereas solid tumors occur less frequently in these patients, and the risk of chemoradiotherapy is unclear. The results indicate that dose-reduction therapy can be effective for treatment of a brain tumor in a patient with Down syndrome.


Asunto(s)
Antineoplásicos/administración & dosificación , Neoplasias Encefálicas/tratamiento farmacológico , Neoplasias Encefálicas/radioterapia , Cisplatino/administración & dosificación , Síndrome de Down/complicaciones , Tumor del Seno Endodérmico/tratamiento farmacológico , Tumor del Seno Endodérmico/radioterapia , Adolescente , Ganglios Basales/patología , Biomarcadores de Tumor/análisis , Neoplasias Encefálicas/sangre , Neoplasias Encefálicas/diagnóstico por imagen , Neoplasias Encefálicas/etiología , Quimioterapia Adyuvante/métodos , Supervivencia sin Enfermedad , Tumor del Seno Endodérmico/sangre , Tumor del Seno Endodérmico/diagnóstico por imagen , Tumor del Seno Endodérmico/etiología , Humanos , Imagen por Resonancia Magnética , Masculino , Radiografía , Radioterapia Adyuvante/métodos , alfa-Fetoproteínas/análisis
20.
J Neurosurg ; 113(2): 369-73, 2010 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-19911894

RESUMEN

A very rare case of continuous hypertension and tachycardia after excision of a cerebellar hemangioblastoma at the dorsal medulla oblongata is presented. This 21-year-old man was admitted to the authors' hospital with a headache and dizziness. Radiological examination revealed a tumor located behind the dorsal medulla oblongata and compressing it substantially. The tumor was completely resected, but after the surgery the patient experienced prolonged hypertension and tachycardia. Postoperative MR imaging showed a small injury at the dorsocaudal medulla that was located at the caudal site of the nucleus of the tractus solitarius (NTS). Because the NTS has been reported to play a central role in cardiovascular regulation along with the rostral ventrolateral medulla, the authors considered it possible that the NTS injury was the cause of the prolonged elevation of sympathetic tone.


Asunto(s)
Enfermedades del Sistema Nervioso Autónomo/etiología , Neoplasias del Tronco Encefálico/cirugía , Hemangioblastoma/cirugía , Hipertensión/etiología , Complicaciones Posoperatorias/etiología , Taquicardia/etiología , Antagonistas Adrenérgicos beta/administración & dosificación , Enfermedades del Sistema Nervioso Autónomo/tratamiento farmacológico , Enfermedades del Sistema Nervioso Autónomo/patología , Barorreflejo , Neoplasias del Tronco Encefálico/patología , Bloqueadores de los Canales de Calcio/administración & dosificación , Diltiazem/administración & dosificación , Hemangioblastoma/patología , Humanos , Hipertensión/tratamiento farmacológico , Imagen por Resonancia Magnética , Masculino , Bulbo Raquídeo/patología , Morfolinas/administración & dosificación , Complicaciones Posoperatorias/tratamiento farmacológico , Complicaciones Posoperatorias/patología , Núcleo Solitario/patología , Taquicardia/tratamiento farmacológico , Urea/administración & dosificación , Urea/análogos & derivados , Sistema Vasomotor/patología , Adulto Joven
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA