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1.

PIKFYVE inhibition mitigates disease in models of diverse forms of ALS.

Hung, Shu-Ting; Linares, Gabriel R; Chang, Wen-Hsuan; Eoh, Yunsun; Krishnan, Gopinath; Mendonca, Stacee; Hong, Sarah; Shi, Yingxiao; Santana, Manuel; Kueth, Chuol; Macklin-Isquierdo, Samantha; Perry, Sarah; Duhaime, Sarah; Maios, Claudia; Chang, Jonathan; Perez, Joscany; Couto, Alexander; Lai, Jesse; Li, Yichen; Alworth, Samuel V; Hendricks, Eric; Wang, Yaoming; Zlokovic, Berislav V; Dickman, Dion K; Parker, J Alex; Zarnescu, Daniela C; Gao, Fen-Biao; Ichida, Justin K.

Cell ; 186(4): 786-802.e28, 2023 02 16.

Artículo en Inglés | MEDLINE | ID: mdl-36754049

2.

Ferrying wingless across the synaptic cleft.

Zarnescu, Daniela C; Zinsmaier, Konrad E.

Cell ; 139(2): 229-31, 2009 Oct 16.

Artículo en Inglés | MEDLINE | ID: mdl-19837027

3.

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease.

Bakkar, Nadine; Starr, Alexander; Rabichow, Benjamin E; Lorenzini, Ileana; McEachin, Zachary T; Kraft, Robert; Chaung, Matthew; Macklin-Isquierdo, Sam; Wingfield, Taylor; Carhart, Briggs; Zahler, Nathan; Chang, Wen-Hsuan; Bassell, Gary J; Betourne, Alexandre; Boulis, Nicholas; Alworth, Samuel V; Ichida, Justin K; August, Paul R; Zarnescu, Daniela C; Sattler, Rita; Bowser, Robert.

Neurobiol Dis ; 149: 105228, 2021 02.

Artículo en Inglés | MEDLINE | ID: mdl-33359139

4.

Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1.

Chu, Miensheng; Novak, Stefanie Mares; Cover, Cathleen; Wang, Anne A; Chinyere, Ikeotunye Royal; Juneman, Elizabeth B; Zarnescu, Daniela C; Wong, Pak Kin; Gregorio, Carol C.

Circulation ; 137(6): 605-618, 2018 02 06.

Artículo en Inglés | MEDLINE | ID: mdl-29101288

5.

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.

Joardar, Archi; Menzl, Judith; Podolsky, Taylor C; Manzo, Ernesto; Estes, Patricia S; Ashford, Sarah; Zarnescu, Daniela C.

Hum Mol Genet ; 24(6): 1741-54, 2015 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-25432537

6.

PABPN1 suppresses TDP-43 toxicity in ALS disease models.

Chou, Ching-Chieh; Alexeeva, Olga M; Yamada, Shizuka; Pribadi, Amy; Zhang, Yi; Mo, Bi; Williams, Kathryn R; Zarnescu, Daniela C; Rossoll, Wilfried.

Hum Mol Genet ; 24(18): 5154-73, 2015 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-26130692

7.

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.

Coyne, Alyssa N; Yamada, Shizuka B; Siddegowda, Bhavani Bagevalu; Estes, Patricia S; Zaepfel, Benjamin L; Johannesmeyer, Jeffrey S; Lockwood, Donovan B; Pham, Linh T; Hart, Michael P; Cassel, Joel A; Freibaum, Brian; Boehringer, Ashley V; Taylor, J Paul; Reitz, Allen B; Gitler, Aaron D; Zarnescu, Daniela C.

Hum Mol Genet ; 24(24): 6886-98, 2015 Dec 15.

Artículo en Inglés | MEDLINE | ID: mdl-26385636

8.

-2019 PLOS Genetics Research Prize: Fruit fly school - language and dialects for communicating a threat.

Barsh, Gregory S; Copenhaver, Gregory P; Prakash, Elapulli Sankaranarayanan; Zarnescu, Daniela C.

PLoS Genet ; 15(9): e1008381, 2019 09.

Artículo en Inglés | MEDLINE | ID: mdl-31513586

9.

Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.

Coyne, Alyssa N; Siddegowda, Bhavani Bagevalu; Estes, Patricia S; Johannesmeyer, Jeffrey; Kovalik, Tina; Daniel, Scott G; Pearson, Antony; Bowser, Robert; Zarnescu, Daniela C.

J Neurosci ; 34(48): 15962-74, 2014 Nov 26.

Artículo en Inglés | MEDLINE | ID: mdl-25429138

10.

A Helping Hand: RNA-Binding Proteins Guide Gene-Binding Choices by Cohesin Complexes.

Coyne, Alyssa N; Zarnescu, Daniela C.

PLoS Genet ; 12(11): e1006419, 2016 11.

Artículo en Inglés | MEDLINE | ID: mdl-27855157

11.

Wild-type and A315T mutant TDP-43 exert differential neurotoxicity in a Drosophila model of ALS.

Estes, Patricia S; Boehringer, Ashley; Zwick, Rebecca; Tang, Jonathan E; Grigsby, Brianna; Zarnescu, Daniela C.

Hum Mol Genet ; 20(12): 2308-21, 2011 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-21441568

12.

Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle.

Whitman, Samantha A; Cover, Cathleen; Yu, Lily; Nelson, David L; Zarnescu, Daniela C; Gregorio, Carol C.

Circ Res ; 109(3): 262-71, 2011 Jul 22.

Artículo en Inglés | MEDLINE | ID: mdl-21659647

13.

Modelling TDP-43 proteinopathy in Drosophila uncovers shared and neuron-specific targets across ALS and FTD relevant circuits.

Godfrey, R Keating; Alsop, Eric; Bjork, Reed T; Chauhan, Brijesh S; Ruvalcaba, Hillary C; Antone, Jerry; Gittings, Lauren M; Michael, Allison F; Williams, Christi; Hala'ufia, Grace; Blythe, Alexander D; Hall, Megan; Sattler, Rita; Van Keuren-Jensen, Kendall; Zarnescu, Daniela C.

Acta Neuropathol Commun ; 11(1): 168, 2023 10 20.

Artículo en Inglés | MEDLINE | ID: mdl-37864255

14.

Fragile X protein controls neural stem cell proliferation in the Drosophila brain.

Callan, Matthew A; Cabernard, Clemens; Heck, Jennifer; Luois, Samantha; Doe, Chris Q; Zarnescu, Daniela C.

Hum Mol Genet ; 19(15): 3068-79, 2010 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-20504994

15.

The cell adhesion molecule Roughest depends on beta(Heavy)-spectrin during eye morphogenesis in Drosophila.

Lee, Hyun-Gwan; Zarnescu, Daniela C; MacIver, Bryce; Thomas, Claire M.

J Cell Sci ; 123(Pt 2): 277-85, 2010 01 15.

Artículo en Inglés | MEDLINE | ID: mdl-20048344

16.

Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production.

Bjork, Reed T; Mortimore, Nicholas P; Loganathan, Suvithanandhini; Zarnescu, Daniela C.

Front Neurosci ; 16: 840357, 2022.

Artículo en Inglés | MEDLINE | ID: mdl-35321094

17.

TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS.

Loganathan, Suvithanandhini; Wilson, Bryce A; Carey, Sara B; Manzo, Ernesto; Joardar, Archi; Ugur, Berrak; Zarnescu, Daniela C.

Metabolites ; 12(2)2022 Jan 21.

Artículo en Inglés | MEDLINE | ID: mdl-35208176

18.

Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells.

Callan, Matthew A; Zarnescu, Daniela C.

Genesis ; 49(6): 424-40, 2011 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-21404421

19.

Measuring Glucose Uptake in Drosophila Models of TDP-43 Proteinopathy.

Loganathan, Suvithanandhini; Ball, Hannah E; Manzo, Ernesto; Zarnescu, Daniela C.

J Vis Exp ; (174)2021 08 03.

Artículo en Inglés | MEDLINE | ID: mdl-34424253

20.

TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.

Lehmkuhl, Erik M; Loganathan, Suvithanandhini; Alsop, Eric; Blythe, Alexander D; Kovalik, Tina; Mortimore, Nicholas P; Barrameda, Dianne; Kueth, Chuol; Eck, Randall J; Siddegowda, Bhavani B; Joardar, Archi; Ball, Hannah; Macias, Maria E; Bowser, Robert; Van Keuren-Jensen, Kendall; Zarnescu, Daniela C.

Acta Neuropathol Commun ; 9(1): 52, 2021 03 24.

Artículo en Inglés | MEDLINE | ID: mdl-33762006

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