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1.
J Hand Surg Am ; 48(4): 396-401, 2023 04.
Artículo en Inglés | MEDLINE | ID: mdl-36623946

RESUMEN

Intraoperative neuromonitoring is a valuable surgical resource that can assist in decision-making during peripheral nerve surgery using real-time electrophysiologic data. By stimulating a nerve and recording action potentials from a point on the nerve ("nerve action potential") or from a muscle ("triggered electromyography"), nerve lesions can be localized and the extent of nerve damage evaluated. The purpose of this article is to provide an overview of the role, indications, and techniques of intraoperative neuromonitoring of peripheral nerve injuries.


Asunto(s)
Monitoreo Intraoperatorio , Procedimientos Neuroquirúrgicos , Traumatismos de los Nervios Periféricos , Humanos , Potenciales de Acción , Electromiografía , Complicaciones Intraoperatorias/cirugía , Monitoreo Intraoperatorio/métodos , Traumatismos de los Nervios Periféricos/cirugía , Nervios Periféricos/cirugía
2.
J Hand Surg Am ; 48(7): 726-731, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-36914452

RESUMEN

Confirming the presence or absence of a functioning nerve root in traumatic brachial plexus injuries is vital in the surgical decision-making process. Intraoperative neuromonitoring can confirm intact rootlets with the use of motor evoked potentials and somatosensory evoked potentials. The purpose of this article is to describe the rationale and details of intraoperative neuromonitoring to provide a basic understanding of its role in decision-making in patients with brachial plexus injuries.


Asunto(s)
Plexo Braquial , Humanos , Plexo Braquial/cirugía , Plexo Braquial/lesiones , Potenciales Evocados Somatosensoriales/fisiología , Potenciales Evocados Motores , Raíces Nerviosas Espinales/lesiones , Raíces Nerviosas Espinales/cirugía
3.
J Hand Surg Am ; 48(9): 952.e1-952.e7, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-35523637

RESUMEN

PURPOSE: The flexor digitorum superficialis (FDS) tendon transfer can be used to restore opposition of the thumb. Several pulley designs have been proposed for this transfer. Gliding resistance is considered to be an important factor influencing the efficiency of the pulley design. Our purpose was to compare the gliding resistance among 4 commonly used pulleys for the FDS oppositional transfer. METHODS: Ten fresh-frozen cadaver specimens were studied. The ring FDS was used as the donor tendon. An oppositional transfer was created using 4 pulley configurations: FDS passed around the flexor carpi ulnaris (a-FCU), FDS passed through a 2.5-cm circumference distally based FCU loop (2.5-FCU), FDS passed through a 3.5-cm circumference distally based FCU loop (3.5-FCU), and FDS passed through a longitudinal split in the FCU tendon (s-FCU). The gliding resistance was measured with the thumb in radial abduction and maximum opposition. RESULTS: In abduction, the average FDS gliding resistance of a-FCU, 2.5-FCU, 3.5-FCU, and s-FCU was 0.66 N (SD, 0.14 N), 0.70 N (SD, 0.14 N), 0.68 N (SD, 0.16 N), and 0.79 N (SD, 0.15 N), respectively. The peak gliding resistance of a-FCU, 2.5-FCU, 3.5-FCU, and s-FCU was 0.75 N (SD, 0.16 N), 0.74 N (SD, 0.15 N), 0.74 N (SD, 0.15 N), and 0.86 N (SD, 0.15 N), respectively. CONCLUSIONS: The average gliding resistance of the s-FCU was found to be significantly higher than that of the a-FCU and 3.5-FCU pulleys. In opposition, there were no differences in average or peak gliding resistance among the different pulley designs. CLINICAL RELEVANCE: In this in vitro cadaveric study, the FDS split pulley produced higher gliding resistance. Consideration of the pulley configuration may improve the overall thumb function by decreasing forces needed to overcome gliding resistance.


Asunto(s)
Transferencia Tendinosa , Tendones , Humanos , Tendones/cirugía , Dedos , Músculo Esquelético , Pulgar/cirugía , Fenómenos Biomecánicos
4.
J Hand Surg Am ; 48(10): 1058.e1-1058.e9, 2023 10.
Artículo en Inglés | MEDLINE | ID: mdl-35534324

RESUMEN

PURPOSE: In patients with late brachial plexus birth injuries, sequelae after acute flaccid myelitis, or chronic adult brachial plexus injury, donor nerves for functioning muscle transplantation are often scarce. We present the results of a potential strategy using the phrenic nerve with staged free gracilis transplantation for upper extremity reanimation in these scenarios. METHODS: A retrospective review was performed on an institutional database of brachial plexus injury or patients with palsy. All patients underwent a staged reconstruction in which the ipsilateral phrenic nerve was extended by an autogenous nerve graft (PhNG), followed by free-functioning gracilis transplantation (PhNG-gracilis). RESULTS: Nine patients (6 cases of late brachial plexus birth injuries, 2 of acute flaccid myelitis, and 1 of adult chronic brachial plexus injury) were included in this study. The median follow-up period following the PhNG-gracilis procedure was 27 months (range, 12-72 months). The goals of the staged PhNG and PhNG-gracilis were primarily finger extension or finger flexion. In some patients, the technique was used to improve both elbow and finger function, tunneling the muscle through the flexor compartment of the upper arm and under the mobile wad at the elbow. All patients exhibited improvement of muscle strength, including in finger extension (4 patients) from M0 to M2; finger flexion (3 patients) from M0 to M3; elbow extension (1 patient) from M0 to M2; and elbow flexion (1 patient) from M2 to M4. CONCLUSIONS: A 2-stage PhNG-gracilis may restore or enhance the residual elbow and/or finger paralysis in chronic brachial plexus injuries. A minimum follow-up period of 3 years is recommended. This technique may remain useful as one of the last reconstructive options to increase power in patients with scarce donor nerves. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic V.


Asunto(s)
Traumatismos del Nacimiento , Neuropatías del Plexo Braquial , Plexo Braquial , Articulación del Codo , Colgajos Tisulares Libres , Músculo Grácil , Expansión del Nervio , Transferencia de Nervios , Adulto , Humanos , Músculo Grácil/trasplante , Nervio Frénico/cirugía , Nervio Frénico/lesiones , Neuropatías del Plexo Braquial/cirugía , Transferencia de Nervios/métodos , Plexo Braquial/lesiones , Articulación del Codo/cirugía , Estudios Retrospectivos , Colgajos Tisulares Libres/inervación , Traumatismos del Nacimiento/cirugía , Rango del Movimiento Articular/fisiología , Resultado del Tratamiento , Recuperación de la Función/fisiología
5.
J Hand Surg Am ; 48(7): 683-690, 2023 07.
Artículo en Inglés | MEDLINE | ID: mdl-37227364

RESUMEN

PURPOSE: Some female upper extremity (UE) surgeons face unique barriers to participation at in-person academic and professional society meetings due to disparate childcare and household duties relative to male surgeons. Webinars may alleviate some of this travel burden and allow for more balanced participation. Our purpose was to evaluate gender diversity within academic webinars with a focus on UE surgery. METHODS: We queried webinars conducted by the following professional societies: American Academy of Orthopaedic Surgeons, American Society for Surgery of the Hand (ASSH), American Association for Hand Surgery, and American Shoulder and Elbow Surgeons societies. Webinars with an UE focus produced between January 2020 and June 2022 were included. Demographic characteristics, including sex and race, were recorded for webinar speakers and moderators. RESULTS: A total of 175 UE webinars were identified, with 173 of 175 (99%) having functioning video links. The 173 webinars had 706 speakers and 173 (25%) were women. Female representation in professional society webinars exceeded their overall participation in their sponsoring organizations. Although women comprise 6% and 15% of the overall American Academy of Orthopaedic Surgeons and ASSH membership, respectively, they accounted for 26% of American Academy of Orthopaedic Surgeons webinar speakers and 19% of ASSH webinar speakers. CONCLUSIONS: Between 2020 and 2022, women comprised 25% of speakers for professional society academic webinars with a focus on UE surgery, which exceeds the proportion of women in the individual sponsoring professional societies. CLINICAL RELEVANCE: Online webinars may mitigate some of the barriers that female UE surgeons face with respect to professional development and academic advancement. Although female participation in UE webinars often exceeded the current rates of female members in the individual professional societies, women remain underrepresented in UE surgery, relative to the percentage of female medical students.


Asunto(s)
Cirujanos Ortopédicos , Cirujanos , Humanos , Masculino , Femenino , Estados Unidos , Mano/cirugía , Extremidad Superior/cirugía , Codo , Sociedades Médicas
6.
Microsurgery ; 43(6): 597-605, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36916232

RESUMEN

INTRODUCTION: Supinator to posterior interosseous nerve (SPIN) transfer allows reconstruction of finger/thumb extension and thumb abduction for low radial nerve palsy, incomplete C6 tetraplegia, and brachial plexus injury affecting C7-T1. No study has compared dorsal versus volar approach to perform SPIN transfer. This comparison is studied in the present work, assessing supinator motor branch length and ability to achieve nerve transfer from either approach. METHODS: Ten fresh frozen cadavers were randomly allocated to receive either a dorsal or volar approach to PIN and supinator radial and ulnar branches (RB = radial, UB = ulnar). Supinator head innervation patterns were documented. RB and UB lengths, forearm lengths measured from ulnar styloid to olecranon, visualization of extensor carpi radialis brevis (ECRB) motor nerve without additional dissection, and ability to perform tension-free nerve transfer were assessed. RESULTS: Nine of 10 specimens had supinator branches innervating both heads. The ECRB nerve was visualized in all volar but only one dorsal approach. No significant differences in forearm length were found. Volar with elbow extended: mean RB length was 35 ± 7.8 mm and UB was 37.8 ± 9.3 mm. Dorsal with elbow extended: mean RB length was 30 ± 4.1 mm and UB was 38.8 ± 7.3 mm. Dorsal with elbow flexed 90°: RB was 25.6 ± 3.8 mm and UB was 34.8 ± 4.8 mm. No significant differences were found in branch lengths between approaches (dorsal vs. volar UB, p = .339; dorsal vs. volar RB, p = .117). All limbs achieved tension-free coaptation. CONCLUSION: Neither approach demonstrated superiority in achieving tension-free nerve transfer. Volar permitted immediate identification of ECRB nerve whereas this was only visualized in one dorsal specimen without additional dissection. Overall, the volar approach allows direct coaptation in elbow extension, mimicking maximal physiologic tension for neurorrhaphy. It simultaneously permits additional procedures for pinch reconstruction via single exposure, circumventing limb/microscope maneuvering, dorsal dissection, and increased operative time. Ultimate choice of approach should depend on surgeon familiarity and potential need for additional simultaneous transfers.


Asunto(s)
Plexo Braquial , Transferencia de Nervios , Humanos , Antebrazo/cirugía , Nervio Radial/cirugía , Transferencia de Nervios/métodos , Plexo Braquial/cirugía , Plexo Braquial/lesiones , Cadáver
7.
J Reconstr Microsurg ; 39(6): 462-471, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-36462712

RESUMEN

BACKGROUND: The decision between local and free tissue coverage for distal lower leg defects has long been dictated by the location and size of defects. Recent reports of distal defects treated successfully with pedicled perforator flaps demonstrate equivalent clinical outcomes; however, the complication rate can be high. The goal of this study was to evaluate the cost equivalence of free versus pedicled perforator flap to assist decision-making and guide clinical care. METHODS: The institutional database was searched for patients with acute injury over the distal lower extremity requiring free or pedicled perforator flap. Demographic, clinical, and total resource cost was gathered. Patients were matched to Gustilo-Anderson or Arbeitsgemeinschaft fur Osteosynthesefragen classification as well as size of defect and outcomes, and cost compared. RESULTS: We have included 108 free flaps and 22 pedicled perforator flaps in the study. There was no difference in complication rate between groups. Free flaps had significantly more reoperations, required longer operative time, and had longer intensive care unit (ICU) care with higher cost of surgery and overall cost than pedicled flaps. When controlling for size of defect, surgical cost remained significantly different between groups (p = 0.013), but overall cost did not. Multivariable regression analysis indicated flap type to be the primary driver of cost of surgery, while body mass index elevated the total cost. CONCLUSION: Pedicled perforator flap coverage for small to medium-sized defects (< 70 cm2) is a viable and cost-effective option for distal lower leg soft tissue reconstruction after acute traumatic injury with similar clinical outcomes and shorter operative duration and ICU stay.


Asunto(s)
Colgajos Tisulares Libres , Colgajo Perforante , Humanos , Pierna/cirugía , Extremidad Inferior/cirugía , Reoperación
8.
J Reconstr Microsurg ; 39(5): 361-366, 2023 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-36261055

RESUMEN

BACKGROUND: Restoring elbow function is challenging after late presenting brachial plexus birth injury (BPBI). Free functioning muscle transplantation (FFMT) using the gracilis muscle is a reliable procedure to restore elbow flexion in patients with impaired function after spontaneous recovery or failed surgical reconstruction. METHODS: A retrospective review was performed on BPBI patients more than 2 years of age who received a FFMT between January 1993 and January 2018, with the aim of improving elbow flexion as the primary or secondary functional goal. Patients with preoperative elbow flexion Medical Research Council (MRC) grades less than 3 with more than or equal to 18 months of follow-up duration were included in the analysis. Patient demographic information and pre/postoperative clinical parameters including elbow flexion MRC scale, passive elbow range of motion, and complications were recorded. Surgical data including donor nerve choice, site of the FFMT tendon attachment, and necessity of concomitant procedures or reoperation were also analyzed. RESULTS: Fifty-six FFMTs were performed for the primary (29 patients) or secondary (26 patients) objective of restoring elbow flexion. The mean age at the time of the procedure was 9.6 years (standard deviation [SD] = 6.29, R = 3-35). Mean follow-up was 7.9 years (SD = 5.2). Elbow flexion improved from a median MRC grade 2 to 4 after a FFMT (p < 0.05). Patients who had a FFMT to restore two functions had 86% lower elbow flexion MRC grades than those who had a FFMT to restore flexion only (p < 0.05). Patients less than 12 years old at the time of surgery had more complications, reoperations, and rates of a flexion contracture more than or equal to 30 degrees than those aged more than 12 years (p < 0.05). CONCLUSION: FFMT is a reliable option for upper extremity reanimation. Patients aged less than 12 years old at the time of FFMT had significantly more complications, reoperations, and rates of postoperative elbow flexion contracture more than or equal to 30 degrees, but equivalent elbow flexion MRC grades. LEVEL OF EVIDENCE: III.


Asunto(s)
Traumatismos del Nacimiento , Neuropatías del Plexo Braquial , Plexo Braquial , Contractura , Articulación del Codo , Colgajos Tisulares Libres , Músculo Grácil , Transferencia de Nervios , Humanos , Niño , Codo , Músculo Grácil/trasplante , Neuropatías del Plexo Braquial/cirugía , Plexo Braquial/cirugía , Articulación del Codo/cirugía , Rango del Movimiento Articular/fisiología , Colgajos Tisulares Libres/trasplante , Contractura/cirugía , Recuperación de la Función , Traumatismos del Nacimiento/cirugía , Traumatismos del Nacimiento/complicaciones , Resultado del Tratamiento , Transferencia de Nervios/métodos
9.
J Reconstr Microsurg ; 39(4): 272-278, 2023 May.
Artículo en Inglés | MEDLINE | ID: mdl-34666407

RESUMEN

BACKGROUND: Loss of elbow flexion is a common sequela of acute brachial plexus injuries (BPIs). The Mackinnon/Oberlin-II double fascicular transfer (DFT) is a widely used method to restore this function in acute C5-6 or C5-7 injuries. This study attempted to evaluate if this technique can be applied reliably for cases involving C8 and/or T1 injuries. METHODS: Adult patients with acute BPIs who underwent the Mackinnon/Oberlin-II DFT in our center between 2008 and 2018 were retrospectively identified. Group I (n = 37) included patients with only C5-6 or C5-7 injury, while group II (n = 32) patients presented C5-8 ± T1 injuries. The demographic data, pre- and postoperative neurologic evaluations, electrodiagnostic studies, and grip strength assessment were collected. RESULTS: A total of 69 patients met the inclusion criteria. Preoperatively, the patients in group II presented poorer nerve conduction and electromyography in both the median and the ulnar nerves and the supply muscles. The percentage of M3 achievement in both groups was 91.9 versus 87.5% and M4 was 73.0 and 71.9%, respectively, which both were not statically significant but the achievement of group II was slower than the group I, 1 to 2 months slower, respectively. Both groups had 57.57 and 46.0% of the postoperative grip power compared with the healthy side, the result of shoulder abduction was not different (p = 0.480). CONCLUSION: With careful preoperative evaluation, early intervention, appropriate intraoperative functional fascicle selection, and aggressive postoperative rehabilitation, indications for the Mackinnon/Oberlin-II DFT technique can safely include acute C5-8 injuries and even partial T1 acute BPIs.


Asunto(s)
Neuropatías del Plexo Braquial , Plexo Braquial , Articulación del Codo , Transferencia de Nervios , Adulto , Humanos , Codo , Estudios Retrospectivos , Neuropatías del Plexo Braquial/cirugía , Resultado del Tratamiento , Transferencia de Nervios/métodos , Articulación del Codo/cirugía , Plexo Braquial/lesiones , Rango del Movimiento Articular/fisiología
10.
J Hand Surg Am ; 47(5): 429-436, 2022 05.
Artículo en Inglés | MEDLINE | ID: mdl-35248427

RESUMEN

PURPOSE: Pyrocarbon implant hemiarthroplasty is a treatment option for select patients with trapeziometacarpal joint arthritis. The long-term revision rates after implant arthroplasty can be as high as 30%. Revision to trapeziectomy has been described for patients who require implant removal; however, few studies have assessed outcomes in patients in this subgroup. METHODS: This was a retrospective review of patients who underwent the conversion of a pyrocarbon carpometacarpal implant to trapeziectomy and suspensionplasty from 2003 to 2019. Patients who met the criteria were then compared with a matched cohort who underwent primary trapeziectomy and suspensionplasty. Patients were matched based on the revision procedure, age, and duration of follow-up. Data regarding demographic information, range of motion, grip and pinch strengths, and the need for subsequent procedures were collected. RESULTS: Twenty-five patients underwent the removal of their pyrocarbon carpometacarpal implant. The patients underwent revision to Thompson suspensionplasty (n = 14), the Weilby procedure (n = 5), ligament reconstruction tendon interposition (n = 2), or a suture-based suspension procedure (n = 4). The age, sex, and preoperative range of motion and strength measures were similar between the 2 groups. All the patients complained of moderate-to-severe pain prior to surgery, which improved in both groups after surgery. Patients who underwent the removal of a pyrocarbon arthroplasty implant lost 6.4° of palmar abduction after surgery. The postoperative grip, opposition strength, apposition pinch strength, and radial and palmar abduction were similar between the 2 groups. CONCLUSIONS: The removal of a pyrocarbon carpometacarpal implant using subsequent trapeziectomy successfully relieves pain in patients in whom pyrocarbon arthroplasty has failed. After revision, patients may lose abduction motion but have similar strength compared with those who undergo primary trapeziectomy. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic III.


Asunto(s)
Articulaciones Carpometacarpianas , Osteoartritis , Hueso Trapecio , Artroplastia/métodos , Carbono , Articulaciones Carpometacarpianas/cirugía , Humanos , Osteoartritis/cirugía , Dolor/cirugía , Rango del Movimiento Articular , Pulgar/cirugía , Hueso Trapecio/cirugía
11.
J Hand Surg Am ; 46(2): 106-113, 2021 02.
Artículo en Inglés | MEDLINE | ID: mdl-32950317

RESUMEN

PURPOSE: This study examined the effect of low-profile volar rim plates (VR), proximally placed standard variable-angle locking plates (pVA-LCP), and distally placed standard variable-angle locking plates (dVA-LCP) on the flexor pollicis longus (FPL) tendon in a cadaver model. We hypothesized that tendons from the VR and pVA-LCP groups would exhibit similar contact pressures, wear patterns, and post-fatigue testing mechanical properties, whereas dVA-LCP tendons would exhibit higher contact pressures, increased tendon wear patterns, and decreased mechanical properties. METHODS: Nine matched pairs of cadaveric specimens were used in this study. Thin-film pressure sensors were used to measure the initial contact loads between plates and FPL tendons. Specimens were cyclically loaded for 10,000 cycles by actuating the FPL tendon. Cycled tendons were harvested, photographed with a stereomicroscope, and graded for wear on a Likert scale by 5 observers who were blinded to the study protocol. Uniaxial tensile testing measured mechanical properties of the tendon: ultimate failure load, ultimate stress, percent stress relaxation, elastic modulus, and stiffness. RESULTS: With regard to the cadaveric FPL tendon, VR and dVA-LCP had increased contact pressure and tendon wear compared with pVA-LCP. There were no significant differences in contact pressure or tendon wear between dVA-LCP and VR. There was no major difference in the tested mechanical properties of the FPL tendon among any of the groups. CONCLUSIONS: Plates placed directly on or beyond the volar rim demonstrate increased contact pressures and increased tendon wear in a cadaveric model. CLINICAL RELEVANCE: Although low-profile plates allow for fixation of smaller volar fragments in the distal radius, they cause substantial contact with the FPL tendon, which may rupture if the plate is not removed.


Asunto(s)
Fracturas del Radio , Traumatismos de los Tendones , Placas Óseas , Cadáver , Fijación Interna de Fracturas , Humanos , Traumatismos de los Tendones/cirugía , Tendones/cirugía
12.
J Hand Surg Am ; 45(2): 131-139, 2020 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-31866152

RESUMEN

Nondissociative carpal instability is instability of an entire carpal row and can lead to vague ulnar-sided wrist pain as well as a clunking wrist. The etiology of this process is most often generalized ligamentous laxity; however, it can infrequently occur as a result of trauma or malalignment of the radiocarpal joint. Whereas treatment remains controversial, the literature supports nonsurgical management and includes patient education, dynamic placement of orthoses, proprioceptive therapy, and extensor carpi ulnaris strengthening. If extensive nonsurgical therapy fails, surgical intervention includes soft tissue and bony procedures, all with high complication and failure rates and limited long-term outcome data.


Asunto(s)
Huesos del Carpo , Inestabilidad de la Articulación , Traumatismos de la Muñeca , Humanos , Inestabilidad de la Articulación/terapia , Muñeca , Articulación de la Muñeca
13.
J Pediatr Orthop ; 38(7): e411-e416, 2018 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-29727409

RESUMEN

BACKGROUND: Price transparency allows patients to make value-based health care decisions and is particularly important for individuals who are uninsured or enrolled in high-deductible health care plans. The availability of consumer prices for children undergoing orthopaedic surgery has not been previously investigated. We aimed to determine the availability of price estimates from hospitals in the United States for an archetypal pediatric orthopaedic surgical procedure (closed reduction and percutaneous pinning of a distal radius fracture) and identify variations in price estimates across hospitals. METHODS: This prospective investigation utilized a scripted telephone call to obtain price estimates from 50 "top-ranked hospitals" for pediatric orthopaedics and 1 "non-top-ranked hospital" from each state and the District of Columbia. Price estimates were requested using a standardized script, in which an investigator posed as the mother of a child with a displaced distal radius fracture that needed closed reduction and pinning. Price estimates (complete or partial) were recorded for each hospital. The number of calls and the duration of time required to obtain the pricing information was also recorded. Variation was assessed, and hospitals were compared on the basis of ranking, teaching status, and region. RESULTS: Less than half (44%) of the 101 hospitals provided a complete price estimate. The mean price estimate for top-ranked hospitals ($17,813; range, $2742 to $49,063) was 50% higher than the price estimate for non-top-ranked hospitals ($11,866; range, $3623 to $22,967) (P=0.020). Differences in price estimates were attributable to differences in hospital fees (P=0.003), not surgeon fees. Top-ranked hospitals required more calls than non-top-ranked hospitals (4.4±2.9 vs. 2.8±2.3 calls, P=0.003). A longer duration of time was required to obtain price estimates from top-ranked hospitals than from non-top-ranked hospitals (8.2±9.4 vs. 4.1±5.1 d, P=0.024). CONCLUSIONS: Price estimates for pediatric orthopaedic procedures are difficult to obtain. Top-ranked hospitals are more expensive and less likely to provide price information than non-top-ranked hospitals, with price differences primarily caused by variation in hospital fees, not surgeon fees. LEVEL OF EVIDENCE: Level II-economic and decision analyses.


Asunto(s)
Reducción Cerrada/economía , Precios de Hospital , Procedimientos Ortopédicos/economía , Fracturas del Radio/economía , Acceso a la Información , Niño , Femenino , Humanos , Masculino , Estudios Prospectivos , Fracturas del Radio/cirugía , Teléfono , Estados Unidos
14.
Proc Natl Acad Sci U S A ; 111(47): E5114-22, 2014 Nov 25.
Artículo en Inglés | MEDLINE | ID: mdl-25385580

RESUMEN

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in cartilage, regulate their metabolic activities in response to mechanical loading. Pathological mechanical stress can lead to maladaptive cellular responses and subsequent cartilage degeneration. We sought to deconstruct chondrocyte mechanotransduction by identifying mechanosensitive ion channels functioning at injurious levels of strain. We detected robust expression of the recently identified mechanosensitive channels, PIEZO1 and PIEZO2. Combined directed expression of Piezo1 and -2 sustained potentiated mechanically induced Ca(2+) signals and electrical currents compared with single-Piezo expression. In primary articular chondrocytes, mechanically evoked Ca(2+) transients produced by atomic force microscopy were inhibited by GsMTx4, a PIEZO-blocking peptide, and by Piezo1- or Piezo2-specific siRNA. We complemented the cellular approach with an explant-cartilage injury model. GsMTx4 reduced chondrocyte death after mechanical injury, suggesting a possible therapy for reducing cartilage injury and posttraumatic osteoarthritis by attenuating Piezo-mediated cartilage mechanotransduction of injurious strains.


Asunto(s)
Cartílago Articular/fisiología , Canales Iónicos/fisiología , Estrés Mecánico , Animales , Señalización del Calcio , Condrocitos/fisiología , Canales Iónicos/genética , Ratones , ARN Interferente Pequeño
15.
Hand (N Y) ; : 15589447241247246, 2024 Apr 23.
Artículo en Inglés | MEDLINE | ID: mdl-38654498

RESUMEN

BACKGROUND: In recent years, ChatGPT has become a popular source of information online. Physicians need to be aware of the resources their patients are using to self-inform of their conditions. This study investigates physician-graded accuracy and completeness of ChatGPT regarding various questions patients are likely to ask the artificial intelligence (AI) system concerning common upper limb orthopedic conditions. METHODS: ChatGPT 3.5 was interrogated concerning 5 common orthopedic hand conditions: carpal tunnel syndrome, Dupuytren contracture, De Quervain tenosynovitis, trigger finger, and carpal metacarpal arthritis. Questions evaluated conditions' symptoms, pathology, management, surgical indications, recovery time, insurance coverage, and workers' compensation possibility. Each topic had 12 to 15 questions and was established as its own ChatGPT conversation. All questions regarding the same diagnosis were presented to the AI, and its answers were recorded. Each question was then graded for both accuracy (Likert scale of 1-6) and completeness (Likert scale of 1-3) by 10 fellowship trained hand surgeons. Descriptive statistics were performed. RESULTS: Overall, the mean accuracy score for ChatGPT's answers to common orthopedic hand diagnoses was 4.83 out of 6 ± 0.95. The mean completeness of answers was 2 out of 3 ± 0.59. CONCLUSIONS: Easily accessible online AI such as ChatGPT is becoming more advanced and thus more reliable in its ability to answer common medical questions. Physicians can anticipate such online resources being mostly correct, however incomplete. Patients should beware of relying on such resources in isolation.

16.
Clin Orthop Relat Res ; 471(11): 3618-25, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23868423

RESUMEN

BACKGROUND: Tumor-induced osteomalacia is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. Phosphaturic mesenchymal tumors represent a rare etiology of tumor-induced osteomalacia. Nonspecific symptoms of fatigue, bone pain, and musculoskeletal weakness make the diagnosis elusive and lead to a delay in surgical treatment. QUESTIONS/PURPOSES: In this case series, the following three questions were asked: (1) How do the clinical presentation and features of phosphaturic mesenchymal tumors delay the diagnosis? (2) What is the clinical course after surgical treatment of phosphaturic mesenchymal tumors? (3) How frequently do phosphaturic mesenchymal tumors recur and are there factors associated with recurrence? METHODS: This study retrospectively reviewed the cases of five adults diagnosed and treated for phosphaturic mesenchymal tumors. Patients were identified through an internal orthopaedic oncology database with clinical, surgical, and histologic data obtained through a systematic chart review. RESULTS: Five patients presented with a long-standing history of osteomalacia, generalized fatigue, pain, and weakness before the diagnosis was reached at an average of 7.2 years (range, 2-12 years) after initial symptom onset. The diagnosis appeared to be delayed owing to the cryptic medical presentation, difficulty in locating tumor by imaging, and confirming histologic appearance. Two patients treated with wide surgical resection did not experience recurrence compared with three patients who did show recurrent signs and symptoms after marginal excision. A postoperative increase in fibroblast-derived growth factor-23 was associated with recurrent disease. CONCLUSIONS: Although uncommon, the diagnosis of phosphaturic mesenchymal tumor should be considered in any patient who presents with hypophosphaturic osteomalacia and no other physiologic cause. Definitive treatment is early, wide surgical resection.


Asunto(s)
Diagnóstico Tardío , Hipofosfatemia/etiología , Mesenquimoma/diagnóstico , Mesenquimoma/cirugía , Neoplasias de Tejido Conjuntivo/etiología , Síndromes Paraneoplásicos/etiología , Tiempo de Tratamiento , Adulto , Anciano , Biomarcadores/sangre , Biomarcadores/orina , Femenino , Factor-23 de Crecimiento de Fibroblastos , Factores de Crecimiento de Fibroblastos/sangre , Humanos , Hipofosfatemia/diagnóstico , Masculino , Mesenquimoma/sangre , Mesenquimoma/complicaciones , Persona de Mediana Edad , Recurrencia Local de Neoplasia , Neoplasias de Tejido Conjuntivo/diagnóstico , Osteomalacia , Síndromes Paraneoplásicos/diagnóstico , Fosfatos/sangre , Fosfatos/orina , Valor Predictivo de las Pruebas , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento
17.
Hand (N Y) ; 18(2_suppl): 102S-110S, 2023 03.
Artículo en Inglés | MEDLINE | ID: mdl-35130736

RESUMEN

BACKGROUND: Radioscapholunate (RSL) fusion is performed for painful radiocarpal arthritis that is typically posttraumatic or inflammatory in nature. The purpose of this study was to determine whether patients with inflammatory conditions undergoing RSL fusion had comparable outcomes as those with posttraumatic arthritis and to determine factors impacting union. METHODS: This was a retrospective review of all RSL fusions over a 25-year period. Demographic information, wrist range of motion, postoperative complications, and surgical technique, including presence or absence of resection of distal scaphoid pole, data were collected. Radiographs were examined for evidence of healing of the RSL fusion site as well as development of midcarpal arthritis. RESULTS: Fifty-six patients underwent RSL fusion. Eight patients required revision of radiocarpal arthrodesis for painful nonunion. The fusion rate was 85.7%, and median 25th to 75th percentile (time to healing was 4.0 3.2-5.2) months. There were no differences in time to or rate of union by inflammatory arthropathy status. Grip strength increased significantly and pain decreased significantly with surgery. Union rate was 90% with the use of K-wires, screws, or staples, which was significantly greater than plates, fusion cups, or multiple implant types. The use of autologous bone graft significantly decreased the rate of nonunion and significantly decreased time to union by 3 months compared to allograft alone. Extension was significantly improved with scaphoid distal pole resection versus without distal scaphoid pole resection. CONCLUSIONS: Radioscapholunate (RSL) fusion is an effective treatment for radiocarpal arthritis but has high nonunion rates. Fixation with K-wires, screws, or staples and use of autograft confers improved union rate.


Asunto(s)
Artritis , Hueso Semilunar , Hueso Escafoides , Humanos , Radio (Anatomía)/cirugía , Hueso Semilunar/diagnóstico por imagen , Hueso Semilunar/cirugía , Hueso Escafoides/diagnóstico por imagen , Hueso Escafoides/cirugía , Artritis/etiología , Artritis/cirugía , Artrodesis/métodos
18.
Tech Hand Up Extrem Surg ; 27(3): 194-198, 2023 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-37218464

RESUMEN

Free functional gracilis transfer is a technique for restoration of upper extremity function following brachial plexus injury, as well as muscle loss from traumatic, oncologic, and congenital causes. However, when used for the latter applications, a functional muscle as well as large skin paddle can be required. Historically, skin paddle size was limited by venous outflow of the gracilis flap, using 1 or 2 venae comitantes, and large unreliable skin paddles resulting in partial necrosis. Therefore, to restore form and function, we herein present a technique of free functional gracilis muscle harvest with inclusion of adjacent greater saphenous vein for inclusion of a large skin paddle with 2 venous drainage systems.


Asunto(s)
Plexo Braquial , Músculo Grácil , Humanos , Músculo Grácil/trasplante , Músculo Esquelético/trasplante , Vena Safena/cirugía , Colgajos Quirúrgicos/irrigación sanguínea , Plexo Braquial/lesiones
19.
Plast Reconstr Surg ; 152(3): 472e-475e, 2023 09 01.
Artículo en Inglés | MEDLINE | ID: mdl-36917744

RESUMEN

BACKGROUND: Obstetric brachial plexus palsy can cause deformities of the upper extremity in up to 92% of patients. Elbow reconstruction is difficult because co-contraction of the elbow flexor (EF) and elbow extensor (EE) muscles makes the traditional treatment strategy ineffective. The authors propose a novel strategy to minimize the effect of co-contraction, comprising transfer of an EF to the triceps and a staged gracilis muscle transplantation [functioning free muscle transplantation (FFMT)] to augment EF. The authors hypothesize this will lead to improved elbow flexion and extension, as well as decreased elbow flexion contracture. METHODS: A single-center retrospective review of patients who received a gracilis FFMT for EF after EF-to-EE transfer was performed. EF/EE strength and range of motion data were collected from the last clinical visit. Patients were excluded if they had fewer than 1.5 years of follow-up. A control group with sequelae of obstetric brachial plexus palsy and nonsurgical treatment was used for comparison. RESULTS: Twenty-one patients were included. Average age at muscle transfer was 7.6 ± 5.5 years (range, 3 to 22 years) and at gracilis FFMT was 10.4 ± 6.0 years (range, 5 to 26 years). Average follow-up was 7.3 ± 6.5 years (range, 1.5 to 14.8 years). After EF-to-EE transfer, EE strength increased significantly from Medical Research Council grade 2.2 ± 0.4 to 3.4 ± 0.5 ( P < 0.0001) and EF decreased from 3.2 ± 1.1 to 1.1 ± 1.1 ( P < 0.0001) and recovered to grade 3.3 ± 0.7 after gracilis FFMT. EF contracture was significantly lower compared with that in the nonsurgical cohort ( P = 0.029). CONCLUSION: Patients who undergo EF-to-EE transfer followed by gracilis FFMT have equivalent EF strength with significantly improved EE and improved elbow flexion contracture. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.


Asunto(s)
Neuropatías del Plexo Braquial , Plexo Braquial , Contractura , Articulación del Codo , Transferencia de Nervios , Femenino , Embarazo , Humanos , Codo , Estudios de Cohortes , Plexo Braquial/cirugía , Articulación del Codo/cirugía , Articulación del Codo/fisiología , Neuropatías del Plexo Braquial/complicaciones , Neuropatías del Plexo Braquial/cirugía , Contractura/etiología , Contractura/cirugía , Estudios Retrospectivos , Rango del Movimiento Articular/fisiología , Parálisis , Resultado del Tratamiento , Transferencia de Nervios/efectos adversos
20.
Plast Reconstr Surg ; 151(3): 655-663, 2023 03 01.
Artículo en Inglés | MEDLINE | ID: mdl-36730250

RESUMEN

BACKGROUND: Early soft-tissue reconstruction of open fractures has been shown to decrease infection rates and improve rates of bony union. The purpose of this study was to compare the rates and time to union of open tibia fractures that underwent soft-tissue coverage. METHODS: A retrospective chart review of 118 patients with open tibia fractures requiring soft-tissue reconstruction treated at a single level 1 trauma center was performed. Demographic data as well as flap type were collected. Union status was determined using modified Radiographic Union Scale in Tibia Fractures score greater than 11. RESULTS: Limb salvage was achieved in 90% of patients. The overall rate of nonunion was 33%. Flap type significantly affected time to union, with local fasciocutaneous and keystone flaps having significantly longer time to union [202 days (SD 120.3)] than all other flap groups ( P = 0.01). Free flaps had significantly shorter time to union than local flaps [115 days (SD 49.6) versus 149 days (SD 75.4); P = 0.02]. Muscle flaps had significantly shorter time to union than fasciocutaneous flaps [123 days (SD 52.4) versus 165 days (SD 104.1); P = 0.04]. This remained true after controlling for fracture location, patient age, need for second flap, and fixation method ( P = 0.037). Patients who underwent an initial soft-tissue reconstruction with a local muscle flap were more likely to require a second flap to achieve wound closure (OR, 3.7; P = 0.008) and needing a second flap significantly increased time to union [162 days (SD 95.9) versus 122 days (SD 51.9); P = 0.03]. CONCLUSION: Flap type affects time to union but not nonunion rate in open tibia fractures. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.


Asunto(s)
Fracturas Abiertas , Colgajos Tisulares Libres , Fracturas de la Tibia , Humanos , Tibia/cirugía , Estudios Retrospectivos , Resultado del Tratamiento , Fracturas de la Tibia/cirugía , Fracturas Abiertas/cirugía
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