Retraction Note: Diagnostic and prognostic value of plasma microRNA-195 in patients with non-small cell lung cancer.

This article [1] is retracted at the request of Editor-in-Chief due to overlap with articles [2-5].None of the authors have responded to any correspondence from the editor or publisher about this retraction.

Diagnostic and prognostic value of plasma microRNA-195 in patients with non-small cell lung cancer.

BACKGROUND: Recently, circulating microRNAs (miRNAs) have been reported to be stably detectable in plasma/serum and to function as potent biomarkers in various cancers. The aim of this study was to evaluate the expression level of plasma miRNA-195 in patients with non-small cell lung cancer (NSCLC) and investigate its diagnostic and prognostic value. METHODS: Quantitative real-time PCR was performed to evaluate plasma miRNA-195 levels in 100 NSCLC patients and 100 healthy volunteers. The association between miRNA-195 expression and clinicopathological factors as well as the overall survival was analyzed. Receiver-operating characteristic (ROC) curve analysis was carried out to assess the potential value of plasma miRNA-195 for NSCLC diagnosis. RESULTS: Plasma miRNA-195 was downregulated in NSCLC patients compared with healthy controls (P < 0.001). Decreased plasma miRNA-195 expression was significantly associated with lymph node metastasis and advanced clinical stage. ROC curve analysis showed that plasma miRNA-195 was a useful marker for NSCLC diagnosis. Multivariate Cox regression analysis confirmed low plasma miRNA-195 expression as an independent unfavorable prognostic factor for NSCLC patients. CONCLUSIONS: These findings indicate that plasma miRNA-195 might serve as a promising biomarker for the early detection and prognosis evaluation of NSCLC.

Differential Diagnosis of Preinvasive Lesions in Small Pulmonary Nodules by Dual Source Computed Tomography Imaging.

This study was aimed to explore the differential diagnosis value of preinvasive lesions/minimally invasive adenocarcinoma and invasive adenocarcinoma manifesting as small pulmonary nodules under dual source computed tomography (DSCT) imaging. The patients with nodular manifestations of adenocarcinoma in situ (AIS)/microinfiltrating adenocarcinoma (MIA) were selected as group X, including 14 cases. A total of 31 cases with nodular infiltrating adenocarcinoma were selected as group Y. The enhanced dual-energy image obtained by DSCT dual-energy scan was transferred to the software to obtain the energy image and iodine distribution map. SPSS 18.0 was used for statistical analysis. P < 0.05 was considered statistically significant. All measurements were labeled as mean x͞±S standard deviation. In the CT findings of microinfiltrating adenocarcinoma and infiltrating adenocarcinoma, lobulation sign, burr sign, vacuole sign, and pleural depression sign can help the diagnosis of infiltrating adenocarcinoma. The results showed that lobulation sign, burr sign, vacuole sign, and pleural depression sign could be used as the distinguishing feature of preinvasive lesion/microinvasive adenocarcinoma and invasive adenocarcinoma. Receiver-operating characteristic (ROC) curve analysis showed that the critical value, sensitivity, and specificity of lesion diameter ≥1.4 cm and CT value ≥14.14HU for diagnosis of invasive lung adenocarcinoma were 1.32 and 14.14, 88.4% and 94.4%, and 67.3% and 75.8%, respectively. There were substantial differences in CT values between the two groups under low energy level (42-99 kev) (P < 0.05). DSCT dual-energy imaging can quantitatively identify preinvasive pulmonary nodules with multiple parameters.