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1.

The landscape of alterations affecting epigenetic regulators in T-cell acute lymphoblastic leukemia: Roles in leukemogenesis and therapeutic opportunities.

Walia, Yashna; de Bock, Charles E; Huang, Yizhou.

Int J Cancer ; 154(9): 1522-1536, 2024 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-38155420

2.

Targeting hyperactive platelet-derived growth factor receptor-ß signaling in T-cell acute lymphoblastic leukemia and lymphoma.

De Coninck, Stien; De Smedt, Renate; Lintermans, Beatrice; Reunes, Lindy; Kosasih, Hansen J; Reekmans, Alexandra; Brown, Lauren M; Van Roy, Nadine; Palhais, Bruno; Roels, Juliette; Van der Linden, Malaika; Van Dorpe, Jo; Ntziachristos, Panagiotis; Van Delft, Frederik W; Mansour, Marc R; Pieters, Tim; Lammens, Tim; De Moerloose, Barbara; De Bock, Charles E; Goossens, Steven; Van Vlierberghe, Pieter.

Haematologica ; 2023 Nov 09.

Artículo en Inglés | MEDLINE | ID: mdl-37941480

3.

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia.

Broux, Michael; Prieto, Cristina; Demeyer, Sofie; Vanden Bempt, Marlies; Alberti-Servera, Llucia; Lodewijckx, Inge; Vandepoel, Roel; Mentens, Nicole; Gielen, Olga; Jacobs, Kris; Geerdens, Ellen; Vicente, Carmen; de Bock, Charles E; Cools, Jan.

Blood ; 134(16): 1323-1336, 2019 10 17.

Artículo en Inglés | MEDLINE | ID: mdl-31492675

4.

Evaluating nuclear translocation of surface receptors: recommendations arising from analysis of CD44.

Thorne, Rick F; Wang, Yan; Zhang, Yan; Jing, Xueli; Zhang, Xu Dong; de Bock, Charles E; Oliveira, Camila S.

Histochem Cell Biol ; 153(2): 77-87, 2020 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-31834485

5.

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL.

Degryse, Sandrine; Bornschein, Simon; de Bock, Charles E; Leroy, Emilie; Vanden Bempt, Marlies; Demeyer, Sofie; Jacobs, Kris; Geerdens, Ellen; Gielen, Olga; Soulier, Jean; Harrison, Christine J; Constantinescu, Stefan N; Cools, Jan.

Blood ; 131(4): 421-425, 2018 01 25.

Artículo en Inglés | MEDLINE | ID: mdl-29187379

6.

Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice.

Baens, Mathijs; Stirparo, Rocco; Lampi, Youlia; Verbeke, Delphine; Vandepoel, Roel; Cools, Jan; Marynen, Peter; de Bock, Charles E; Bornschein, Simon.

Eur J Immunol ; 48(10): 1728-1738, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-30025160

7.

FAT1 cadherin controls neuritogenesis during NTera2 cell differentiation.

Ahmed, Abdulrzag F; de Bock, Charles E; Sontag, Estelle; Hondermarck, Hubert; Lincz, Lisa F; Thorne, Rick F.

Biochem Biophys Res Commun ; 514(3): 625-631, 2019 06 30.

Artículo en Inglés | MEDLINE | ID: mdl-31076104

8.

BETter insight into PRC2-mutated T-ALL.

de Bock, Charles E; Cools, Jan.

Blood ; 138(19): 1787-1788, 2021 11 11.

Artículo en Inglés | MEDLINE | ID: mdl-34762130

9.

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors.

Dagklis, Antonis; Demeyer, Sofie; De Bie, Jolien; Radaelli, Enrico; Pauwels, Daphnie; Degryse, Sandrine; Gielen, Olga; Vicente, Carmen; Vandepoel, Roel; Geerdens, Ellen; Uyttebroeck, Anne; Boeckx, Nancy; de Bock, Charles E; Cools, Jan.

Blood ; 128(23): 2642-2654, 2016 12 08.

Artículo en Inglés | MEDLINE | ID: mdl-27694322

10.

Cell biology: A mitochondrial brake on vascular repair.

de Bock, Charles E; Thorne, Rick F.

Nature ; 539(7630): 503-505, 2016 11 24.

Artículo en Inglés | MEDLINE | ID: mdl-27828945

11.

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model.

Degryse, Sandrine; de Bock, Charles E; Cox, Luk; Demeyer, Sofie; Gielen, Olga; Mentens, Nicole; Jacobs, Kris; Geerdens, Ellen; Gianfelici, Valentina; Hulselmans, Gert; Fiers, Mark; Aerts, Stein; Meijerink, Jules P; Tousseyn, Thomas; Cools, Jan.

Blood ; 124(20): 3092-100, 2014 Nov 13.

Artículo en Inglés | MEDLINE | ID: mdl-25193870

12.

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia.

Peirs, Sofie; Matthijssens, Filip; Goossens, Steven; Van de Walle, Inge; Ruggero, Katia; de Bock, Charles E; Degryse, Sandrine; Canté-Barrett, Kirsten; Briot, Delphine; Clappier, Emmanuelle; Lammens, Tim; De Moerloose, Barbara; Benoit, Yves; Poppe, Bruce; Meijerink, Jules P; Cools, Jan; Soulier, Jean; Rabbitts, Terence H; Taghon, Tom; Speleman, Frank; Van Vlierberghe, Pieter.

Blood ; 124(25): 3738-47, 2014 Dec 11.

Artículo en Inglés | MEDLINE | ID: mdl-25301704

13.

FAT1 cadherin acts upstream of Hippo signalling through TAZ to regulate neuronal differentiation.

Ahmed, Abdulrzag F; de Bock, Charles E; Lincz, Lisa F; Pundavela, Jay; Zouikr, Ihssane; Sontag, Estelle; Hondermarck, Hubert; Thorne, Rick F.

Cell Mol Life Sci ; 72(23): 4653-69, 2015 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-26104008

14.

Furin processing dictates ectodomain shedding of human FAT1 cadherin.

Sadeqzadeh, Elham; de Bock, Charles E; Wojtalewicz, Natalie; Holt, Janet E; Smith, Nathan D; Dun, Matthew D; Schwarte-Waldhoff, Irmgard; Thorne, Rick F.

Exp Cell Res ; 323(1): 41-55, 2014 Apr 15.

Artículo en Inglés | MEDLINE | ID: mdl-24560745

15.

Sleeping giants: emerging roles for the fat cadherins in health and disease.

Sadeqzadeh, Elham; de Bock, Charles E; Thorne, Rick F.

Med Res Rev ; 34(1): 190-221, 2014 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-23720094

16.

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development.

de Bock, Charles E; Down, Michelle; Baidya, Kinsha; Sweron, Bram; Boyd, Andrew W; Fiers, Mark; Burns, Gordon F; Molloy, Timothy J; Lock, Richard B; Soulier, Jean; Taghon, Tom; Van Vlierberghe, Pieter; Cools, Jan; Holst, Jeff; Thorne, Rick F.

Haematologica ; 104(5): e204-e207, 2019 05.

Artículo en Inglés | MEDLINE | ID: mdl-30514801

17.

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma.

Oliveira, Camila S; de Bock, Charles E; Molloy, Timothy J; Sadeqzadeh, Elham; Geng, Xin Yan; Hersey, Peter; Zhang, Xu Dong; Thorne, Rick F.

BMC Cancer ; 14: 630, 2014 Aug 29.

Artículo en Inglés | MEDLINE | ID: mdl-25168062

18.

The tumour suppressor Fat1 is dispensable for normal murine hematopoiesis.

Zhang, Qing; Li, Meng Ke; Hu, Xin Yuan; Wu, Yu Xin; Wang, Ying Ying; Zhao, Pan Pan; Cheng, Lin Na; Yu, Rong Hua; Zhang, Xu Dong; Chen, Song; Zhu, Zun Min; de Bock, Charles E; Thorne, Rick F.

J Leukoc Biol ; 2024 Jun 04.

Artículo en Inglés | MEDLINE | ID: mdl-38833591

19.

In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts.

Randall, Joanna; Evans, Kathryn; Watts, Ben; Kosasih, Hansen J; Smith, Christopher M; Earley, Eric J; Erickson, Stephen W; Jocoy, Emily L; Bult, Carol J; Teicher, Beverly A; de Bock, Charles E; Smith, Malcolm A; Lock, Richard B.

Exp Hematol ; 132: 104176, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38320689

20.

PI3K/mTOR is a therapeutically targetable genetic dependency in diffuse intrinsic pontine glioma.

Duchatel, Ryan J; Jackson, Evangeline R; Parackal, Sarah G; Kiltschewskij, Dylan; Findlay, Izac J; Mannan, Abdul; Staudt, Dilana E; Thomas, Bryce C; Germon, Zacary P; Laternser, Sandra; Kearney, Padraic S; Jamaluddin, M Fairuz B; Douglas, Alicia M; Beitaki, Tyrone; McEwen, Holly P; Persson, Mika L; Hocke, Emily A; Jain, Vaibhav; Aksu, Michael; Manning, Elizabeth E; Murray, Heather C; Verrills, Nicole M; Sun, Claire Xin; Daniel, Paul; Vilain, Ricardo E; Skerrett-Byrne, David A; Nixon, Brett; Hua, Susan; de Bock, Charles E; Colino-Sanguino, Yolanda; Valdes-Mora, Fatima; Tsoli, Maria; Ziegler, David S; Cairns, Murray J; Raabe, Eric H; Vitanza, Nicholas A; Hulleman, Esther; Phoenix, Timothy N; Koschmann, Carl; Alvaro, Frank; Dayas, Christopher V; Tinkle, Christopher L; Wheeler, Helen; Whittle, James R; Eisenstat, David D; Firestein, Ron; Mueller, Sabine; Valvi, Santosh; Hansford, Jordan R; Ashley, David M.

J Clin Invest ; 134(6)2024 Feb 06.

Artículo en Inglés | MEDLINE | ID: mdl-38319732

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