Ischemic core and hypoperfusion volumes predict infarct size in SWIFT PRIME.

OBJECTIVE: Within the context of a prospective randomized trial (SWIFT PRIME), we assessed whether early imaging of stroke patients, primarily with computed tomography (CT) perfusion, can estimate the size of the irreversibly injured ischemic core and the volume of critically hypoperfused tissue. We also evaluated the accuracy of ischemic core and hypoperfusion volumes for predicting infarct volume in patients with the target mismatch profile. METHODS: Baseline ischemic core and hypoperfusion volumes were assessed prior to randomized treatment with intravenous (IV) tissue plasminogen activator (tPA) alone versus IV tPA + endovascular therapy (Solitaire stent-retriever) using RAPID automated postprocessing software. Reperfusion was assessed with angiographic Thrombolysis in Cerebral Infarction scores at the end of the procedure (endovascular group) and Tmax > 6-second volumes at 27 hours (both groups). Infarct volume was assessed at 27 hours on noncontrast CT or magnetic resonance imaging (MRI). RESULTS: A total of 151 patients with baseline imaging with CT perfusion (79%) or multimodal MRI (21%) were included. The median baseline ischemic core volume was 6 ml (interquartile range= 0-16). Ischemic core volumes correlated with 27-hour infarct volumes in patients who achieved reperfusion (r = 0.58, p < 0.0001). In patients who did not reperfuse (<10% reperfusion), baseline Tmax > 6-second lesion volumes correlated with 27-hour infarct volume (r = 0.78, p = 0.005). In target mismatch patients, the union of baseline core and early follow-up Tmax > 6-second volume (ie, predicted infarct volume) correlated with the 27-hour infarct volume (r = 0.73, p < 0.0001); the median absolute difference between the observed and predicted volume was 13 ml. INTERPRETATION: Ischemic core and hypoperfusion volumes, obtained primarily from CT perfusion scans, predict 27-hour infarct volume in acute stroke patients who were treated with reperfusion therapies.

Implementation of the ultra low field intraoperative MRI PoleStar N20 during resection control of pituitary adenomas.

OBJECTIVE: To describe our experience with the application of an intraoperative ultra low field magnetic resonance imaging system (ioMRI) PoleStar N20, Medtronic Surgical Navigation Technologies, Louisville, USA during resection control of pituitary adenomas. METHODS: Forty-four patients were operated on a pituitary adenoma (1 microadenoma, 43 macroadenomas; mean size 26.0 ± 9.7 mm). The ioMRI system was used for navigation and resection control after transseptal, transsphenoidal microsurgical tumour removal using standard instruments and standard microscope. If any accessible tumour remnant was suspected surgery was continued for navigation guided re-exploration and if necessary continued resection. RESULTS: The applications of the scanner integrated navigation system, with a 3-planar reconstruction of the coronal scan, enabled the surgeon to safely approach and remove the tumour. The quality of preoperative tumour visualization with the ultra low field ioMRI in patients with macroadenomas is very good and has a good congruency with the preoperative 1.5 T MRI. For microadenomas the preoperative visualization is poor and very difficult to interpret. In seven patients ioMRI resection control showed residual tumours leading to further resection. After final tumour resection the ioMRI scan documented adequate decompression of the optic pathway in all patients. However, the intraoperative image interpretation was equivocal in four patients in whom it was difficult to distinguish between small intrasellar tumour remnants and perioperative changes. CONCLUSIONS: The PoleStar N20 is a safe, helpful and feasible tool for navigation guided pituitary tumour approach. Image interpretation is requires some experience, but decompression of the optic system can be reliable shown in cases with pituitary macroadenomas. This system is of limited value for resection control of pituitary microadenomas.

Early diffusion-weighted MRI lesions after treatment of unruptured intracranial aneurysms: a prospective study.

OBJECTIVE Diffusion-weighted MRI was used to assess periprocedural lesion load after repair of unruptured intracranial aneurysms (UIA) by microsurgical clipping (MC) and endovascular coiling (EC). METHODS Patients with UIA were assigned to undergo MC or EC according to interdisciplinary consensus and underwent diffusion-weighted imaging (DWI) 1 day before and 1 day after aneurysm treatment. Newly detected lesions by DWI after treatment were the primary end point of this prospective study. Lesions detected by DWI were categorized as follows: A) 1-3 DWI spots < 10 mm, B) > 3 DWI spots < 10 mm, C) single DWI lesion > 10 mm, or D) DWI lesion related to surgical access. RESULTS Between 2010 and 2014, 99 cases were included. Sixty-two UIA were treated by MC and 37 by EC. There were no significant differences between groups in age, sex, aneurysm size, occurrence of multiple aneurysms in 1 patient, or presence of lesions detected by DWI before treatment. Aneurysms treated by EC were significantly more often located in the posterior circulation (p < 0.001). Diffusion-weighted MRI detected new lesions in 27 (43.5%) and 20 (54.1%) patients after MC and EC, respectively (not significant). The pattern of lesions detected by DWI varied significantly between groups (p < 0.001). Microembolic lesions (A and B) found on DWI were detected more frequently after EC (A, 14 cases; B, 5 cases) than after MC (A, 5 cases), whereas C and D were rare after EC (C, 1 case) and occurred more often after MC (C, 12 cases and D, 10 cases). No procedure-related unfavorable outcomes were detected. CONCLUSIONS According to the specific techniques, lesion patterns differ between MC and EC, whereas the frequency of new lesions found on DWI is similar after occlusion of UIA. In general, the lesion load was low in both groups, and lesions were clinically silent. Clinical trial registration no.: NCT01490463 ( clinicaltrials.gov ).

Effects of balloon angioplasty on perfusion- and diffusion-weighted magnetic resonance imaging results and outcome in patients with cerebral vasospasm.

OBJECT: The aim of this study was to analyze the effects and outcome of transluminal balloon angioplasty (TBA) on brain tissue perfusion by using combined perfusion- and diffusion-weighted (PW/DW) magnetic resonance (MR) imaging in patients with cerebral vasospasm after subarachnoid hemorrhage. METHODS: Ten consecutive patients with cerebral vasospasm treated using TBA were included in this prospective study. Hemodynamically relevant vasospasm was diagnosed using a standardized PW/DW MR imaging protocol. Digital subtraction angiography was used to confirm vasospasm, and TBA was performed to dilate vasospastic arteries. The PW/DW imaging protocol was repeated after TBA. The evaluation of the passage of contrast medium after standardized application using the bolus tracking method allowed for the calculation of the time to peak (TTP) before and after TBA. Tissue at risk was defined based on perfusion delays in individual vessel territories compared with those in reference territories. In cases with proximal focal vasospasm, TBA could dilate spastic arteries. Follow-up PW/DW MR imaging showed the disappearance of, or a decrease in, the mismatch. A TBA-induced reduction in the perfusion delay of 6.2 +/- 1 seconds (mean +/- standard error of the mean) to 1.5 +/- 0.45 seconds resulted in the complete prevention of infarction; a reduction in the delay of 6.2 +/- 2.7 to 4.1 +/- 1.9 seconds resulted in the preservation of those brain tissue parts having only small infarcts in the vessel territories. Without TBA, however, the perfusion delay remained or even increased (11.1 +/- 3.7 seconds), and the complete infarction of a territory occurred. CONCLUSIONS: Angioplasty of vasospastic arteries leads to hemodynamic effects that can be quantified using PW/DW MR imaging. In cases of a severe PW/DW imaging mismatch successful TBA improved tissue perfusion and prevented cerebral infarction. The clinical significance of PW/DW MR imaging and the concept of tissue at risk is shown by cerebral infarction in vessels not accessible by TBA.

Relation between relative cerebral blood flow, relative cerebral blood volume, and mean transit time in patients with acute ischemic stroke determined by perfusion-weighted MRI.

The relation between relative cerebral blood flow (relCBF), relative cerebral blood volume (relCBV), and mean transit time (MTT) changes was examined in 20 patients with acute cerebral ischemia (<6 h) using perfusion-weighted magnetic resonance imaging. Regions of interest (ROI) were selected on MTT maps covering the entire MTT abnormal cortical area. These ROIs were transferred to the relCBF and relCBV maps to analyze the relation between relCBF, relCBV, and MTT on a voxel-by-voxel basis. On the unaffected side, a tight coupling of relCBF and relCBV was found with little variation of MTT. In hypoperfused cortex, relCBV was increased at all investigated relCBF categories, and there was greater relCBV variability than on the unaffected side. Only a severe decrease of relCBF, to less than 0.3, in comparison with the unaffected side was associated with a reduction of relCBV less than 1.0. In contrast to the unaffected side, a power law function (relCBV = 2.283 x relCBF0.549) resulted in a better fit than using a linear function for the correlation of relCBF and relCBV. MTT ratios increased steadily with decreasing CBF values. In conclusion, there is a clear relation between different perfusion-weighted magnetic resonance imaging parameters in acute ischemia, reflecting both the degree of hemodynamic failure as well as compensatory mechanisms including vasodilation.

Evaluation of angiographic and technical aspects of carotid stenting with diffusion-weighted magnetic resonance imaging.

The detection of clinically silent ischemic lesions on postprocedural diffusion-weighted magnetic resonance images has become a preferred method for the description of embolic risks. The purpose of this single-center study was to evaluate whether diffusion-weighted imaging (DWI) could determine material related or technical risk factors of filter-protected carotid stenting. Eighty-four patients with symptomatic severe (> or = 60%) carotid artery stenoses received filter-protected carotid stenting. Standard DWI (b = 1000) was performed within 48 h before and after carotid stenting. The occurrence and load of new postinterventional DWI lesions were assessed. Multivariate analysis was performed to determine risk factors associated with DWI lesions, with emphasis on technical factors such as use of different access devices (guiding catheter method vs. long carotid sheath method), type of stent (open-cell nitinol stent vs. closed-cell Wallstent), and protective device (filters with 80-microm vs. 110-120-microm pore size). Markers for generalized atherosclerosis and for degree and site of stenosis were assessed to allow comparison of adequate risk profiles. Access, protective device, and stent type were not significantly associated with new embolic DWI lesions when we compared patients with equivalent risk profiles (long carotid sheath method 48% [11 of 23] vs. guiding catheter method 44% [27 of 61], Wallstent 47% [15 of 32] vs. nitinol stent 44% [23 of 52], and small pore size filter 61% [11 of 18] vs. large pore size filter 41% [27 of 66]). Single-center DWI studies with a moderate number of cases are inadequate for proper assessment of the embolic risk of technical- or material-related risk factors in carotid stenting. Larger multicenter studies with more cases are needed.

Recurrent symptomatic high-grade intracranial stenoses: safety and efficacy of undersized stents--initial experience.

PURPOSE: To prospectively evaluate the safety and efficacy of undersized stents used in patients with high-grade intracranial stenosis and recurrent ischemic symptoms who are undergoing medical treatment. MATERIALS AND METHODS: In 18 patients (13 men, five women; age range, 51-82 years), 20 high-grade (>70%) intracranial stenoses were selected for stent placement. All patients had transient ischemic symptoms or minor strokes while undergoing combined antithrombotic therapy with acetylsalicylic acid plus clopidogrel or anticoagulation therapy with warfarin or heparin plus acetylsalicylic acid. Technical success was defined as reaching the target lesion and deploying a stent, with a residual stenosis of less than 50%. The diameter of the stent was 0.5-mm smaller than the measured diameter of the normal adjacent vessel to avoid dissection and vessel rupture. Primary endpoints for safety evaluation were the combined incidence of death or major or minor stroke at 30 days; for efficacy evaluation, the primary endpoint was the incidence of any stroke in the treated vascular territory within the first 6 months. Statistical evaluation of the reduction of stenosis was performed. RESULTS: In 18 of 20 stenoses, a stent was placed and the degree of stenosis was reduced from a median of 82% (range, 72%-97%) to a median of 16% (5%-40%; P <.001). The technical success rate was 90%. One patient had a parenchymal hemorrhage in a preexisting infarct on the 2nd day. Thus, the 30-day combined stroke and death rate was 6%. No immediate complication, thromboembolism, dissection compromising blood flow, or vessel rupture occurred during these procedures. Within the first 6 months after intervention, no patient had new ischemic symptoms in the treated vascular territory. CONCLUSION: In selected patients with recurrent ischemic events due to high-grade intracranial stenosis, undersized stent placement holds promise as an effective and safe procedure.