RESUMEN
This study aimed to investigate the antioxidant and protective effect of E. persicus leaf hydroalcoholic extract (EPE) in preventing gastric ulcers induced by ethanol in rats. Wistar rats weighing 180-220 g were randomly divided into five groups. These groups included negative control (normal) group, positive control (ethanolic) group, comparative control (ranitidine recipient) group, group recipient the dose of 250 mg/kg plant extract, and group recipient the dose of 500 mg/kg plant extract. One hour after gavage of the drug and extract, the gastric ulcer was induced by feeding 1 ml of 96% ethanol to each animal except the rats of the negative control group. After one hour, the rats were killed, and their stomachs were separated. Then, the gastric Ulcer index (UI), pH, oxidative stress parameters, and histopathological changes in the stomach of all groups were measured. Pre-treatment of ethanol-induced rats with the EPE reduced (P < 0.05) the ulcer index and gastric juice pH, compared to ethanolic group rats. Furthermore, pre-treatment with EPE at a dose-dependent manner, alleviated the gastric oxidative stress injury in rats through increase the activity of CAT, tissue NO· and GSH levels. EPE also was able to decrease the levels of ROS, MDA, PCO and serum NO·. According to the results, it can be concluded that pre-treatment with EPE prevents the formation of gastric ulcers caused by ethanol, which can be attributed to the antioxidant activity of plant polyphenols compounds.
Asunto(s)
Antiulcerosos/farmacología , Antioxidantes/farmacología , Asphodelaceae/química , Extractos Vegetales/farmacología , Animales , Antiulcerosos/administración & dosificación , Antiulcerosos/aislamiento & purificación , Antioxidantes/administración & dosificación , Antioxidantes/aislamiento & purificación , Relación Dosis-Respuesta a Droga , Etanol/toxicidad , Masculino , Estrés Oxidativo/efectos de los fármacos , Extractos Vegetales/administración & dosificación , Hojas de la Planta , Polifenoles/aislamiento & purificación , Polifenoles/farmacología , Ranitidina/farmacología , Ratas , Ratas Wistar , Úlcera Gástrica/prevención & controlRESUMEN
Eremurus persicus (Jaub. & Spach) Boiss. commonly known as "Serish" is a valuable ornamental plant with culinary uses and also utilized in traditional medicine for treating Gastrointestinal diseases. This comprehensive study was performed to investigate the pharmacological and biological effects of E. persicus and the compounds identified and isolated from it in order to encourage researchers to study it further. Despite the few number of studies on the ethnopharmacology of the plant E. persicus, however studies conducted on either crude extracts, solvent fractions or isolated pure compounds from E. persicus a varied range of biological effects comprising antibacterial, anti-fungal, anti-diabetic and etc. have reported. Phytochemical analysis of different parts of E. persicus unveiled 52 phytochemicals. However, the toxicity of this plant and its ethnopharmacological claims should be thoroughly investigated.