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Int J Gynaecol Obstet ; 148(1): 96-101, 2020 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-31560127

RESUMEN

OBJECTIVE: To probe the influence of metabolic syndrome (MS) on the long-term survival of patients with non-endometrioid adenocarcinoma. METHODS: Between January 2003 and December 2012, 139 Chinese patients with non-endometrial adenocarcinoma were analyzed in a retrospective study. Patients who had received any treatment before surgery were excluded. Survival times were compared between patients with and without MS. RESULTS: Overall, 41 (29.5%) patients had MS; the highest incidence of MS was observed in those with uterine serous carcinoma (19/45, 42.2%). For uterine serous carcinoma or adenosquamous carcinoma, MS was an independent predictive factor of morbidity (P=0.023 and 0.016, respectively). For the overall population, those with MS had a significantly lower survival rate than those without MS (P=0.008), and the median overall survival (mOS) was 15 months versus 55 months (P<0.001, hazard ratio [HR] 0.45, 95% confidence interval [CI] 0.29-0.69). Similarly, a lower survival rate (P=0.020) and shorter mOS (19 months vs 55 months, P=0.007, HR 0.41, 95% CI 0.20-0.83) were also found in the uterine serous carcinoma population with MS. Multivariate Cox regression analyses showed that disease stage (P=0.023) and MS (P=0.008) were independent prognostic factors for uterine serous carcinoma. CONCLUSION: The present study suggests that MS is a prognostic factor for non-endometrioid adenocarcinoma, especially uterine serous carcinoma.


Asunto(s)
Carcinoma Adenoescamoso/mortalidad , Cistadenocarcinoma Seroso/mortalidad , Síndrome Metabólico/complicaciones , Neoplasias Uterinas/mortalidad , Adulto , Anciano , Carcinoma Adenoescamoso/complicaciones , Carcinoma Adenoescamoso/patología , Estudios de Casos y Controles , Cistadenocarcinoma Seroso/complicaciones , Cistadenocarcinoma Seroso/patología , Femenino , Humanos , Persona de Mediana Edad , Modelos de Riesgos Proporcionales , Estudios Retrospectivos , Tasa de Supervivencia , Neoplasias Uterinas/complicaciones , Neoplasias Uterinas/patología
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