Epidemiology and management of oral cavity squamous cell carcinoma in Ireland.

INTRODUCTION: The epidemiology and management of oral cavity cancer have changed considerably in recent decades. This study examines epidemiological and management trends in oral cavity squamous cell carcinoma (OCSCC). METHODS: A retrospective cohort study of data from the National Cancer Registry of Ireland between 1994 and 2014. RESULTS: A total of 2725 patients were identified. The most common subsites were the tongue (34 %, n = 1025), lip (19 %, n = 575), floor of mouth (FOM) (18 %, n = 550), and retromolar trigone (RMT) (6 %, n = 189). The incidence of OCSCC remained largely unchanged (3.14 cases/100000/year) during the study period. 5-year disease-specific survival (DSS) was 58.6 % overall, varying between subsites (lip 85 %, RMT 62.9 %, tongue 54.7 %, and FOM 47.3 %). DSS improved over the study period (p = 0.03), in particular for tongue primaries (p = 0.007). Primary surgery significantly improved DSS versus radiotherapy (HR 0.28, p < 0.0001). Survival of T4 disease managed surgically was superior to that of T1 disease managed with radiotherapy. In node positive patients, chemotherapy improved overall survival (HR 0.8 p = 0.038) but not DSS (HR 0.87 p = 0.215). CONCLUSION: Primary surgery remains the standard of care in the management of OCSCC. Prognosis has improved in line with an increase in the use of primary surgery in the same time frame, though the incidence remains unchanged.

Análisis descriptivo del cáncer oral en el municipio de pasto

Introducción: El propósito del presente estudio fue realizar un análisis descriptivo del cáncer oral en el Municipio de Pasto, el cual no había sido caracterizado, analizado y divulgado antes cuando la incidencia de cáncer oral a nivel mundial y nacional incrementa, igualmente la exposición a factores de riesgo. Método: Un estudio retrospectivo descriptivo basado en los 99 casos de cáncer oral reportados en el Registro Poblacional de Cáncer del Municipio de Pasto desde el año 1998 al 2002. La información seleccionada se dividió en dos grupos de variables, la primera correspondiente a los aspectos sociodemográficos y una segunda correspondiente a los aspectos diagnósticos. Resultados: Los 99 casos de cáncer oral tienen una tasa cruda (TC) de 7.82 casos por 100.000 habitantes y una tasa ajustada por edad (TAE) de 8.51 (IC 95%: 7.13-9.9). La incidencia específica o por género fue de 43 nuevos casos en hombres con una TC de 6.54 por 100.000 habitantes y una TAE de 8.02; en mujeres se presentaron 52 nuevos casos con una TC de 9.03 por 100.000 habitantes y una TAE de 8.99. Conclusión: el presente estudio mostró una incidencia del cáncer oral en hombres y mujeres bastante similar, mientras que las otras variables mostraron ser coherentes con los resultados de otros estudios a nivel mundial.

Introduction: The purpose of this study was to carry out a descriptive analysis of oral cancer in the municipality of Pasto. Such study has not been characterized, analyzed and spread before despite the fact that oral cancer incidence level increases worldwide and nationwide as well as the exposure to risk factors. Method: A retrospective study was done. It was based in 99 cases of reported oral cancer in the Cancer Population Registration in the Municipality of Pasto from 1998 to 2002. The selected information was divided in two variable groups. The first one belongs to the socio-demographic aspects and the second belongs to the diagnosis aspects. Results: The 99 cases of oral cancer have a crude rate (CR) of 7.82 cases per 100.000 inhabitants and an age-adjusted rate (AAR) of 8.51(CI 95%: 7.13-9.9). The specific incidence or by genre was of 43 new cases in men with a CR of 6.54 per 100.000 inhabitants and an AAR of 8.02; while 52 new cases with a CR of 9.03 per 100.000 inhabitants and an AAR of 8.99 were presented in women. Conclusion: The present study showed a similar oral cancer incidence in men and women, while other variables showed the coherence with results of worldwide level studies.