An Analysis of the Latent Class and Influencing Factors of Death Anxiety Among Han Chinese and Tibetan College Students.

In this study, 349 Han and 217 Tibetan college students were investigated via the Templer Death Anxiety Scale in order to assess the potential class and influencing factors of death anxiety among them. In addition, Mplus software was used to analyse the latent categories of their death anxiety, and an R3STEP approach was adopted to perform a multinomial logistic regression of its influencing factors. Whilst the results of the former indicated that there are two latent classes, respectively, defined as 'high death anxiety type' (Han 65.20%; Tibetan 30.30%) and 'low death anxiety type' (Han 34.80%; Tibetan 69.70%), the latter demonstrated that compared with the 'low death anxiety type', the occurrence ratio of the 'high death anxiety type' was 47.00 and 34.04 percentage points higher with each increase in age. Furthermore, the stress and anxiety of Han and Tibetan college students were found to constitute factors that affect death anxiety. More specifically, the death anxiety of Tibetan college students was determined to be deeply influenced by a belief in the afterlife.

Novel insight into the genetic signatures of altitude adaptation related body composition in Tibetans.

Background: The Tibetan population residing in high-altitude (HA) regions has adapted to extreme hypoxic environments. However, there is limited understanding of the genetic basis of body compositions in Tibetan population adapted to HA. Methods: We performed a genome-wide association study (GWAS) to identify genetic variants associated with HA and HA-related body composition traits. A total of 755,731 single nucleotide polymorphisms (SNPs) were genotyped using the precision medicine diversity array from 996 Tibetan college students. T-tests and Pearson correlation analysis were used to estimate the association between body compositions and altitude. The mixed linear regression identified the SNPs significantly associated with HA and HA-related body compositions. LASSO regression was used to screen for important SNPs in HA and body compositions. Results: Significant differences were observed in lean body mass (LBW), muscle mass (MM), total body water (TBW), standard weight (SBW), basal metabolic rate (BMR), total protein (TP), and total inorganic salt (Is) in different altitudes stratification. We identified three SNPs in EPAS1 (rs1562453, rs7589621 and rs7583392) that were significantly associated with HA (p < 5 × 10-7). GWAS analysis of 7 HA-related body composition traits, we identified 14 SNPs for LBM, 11 SNPs for TBW, 15 SNPs for MM, 16 SNPs for SBW, 9 SNPs for BMR, 12 SNPs for TP, and 26 SNPs for Is (p < 5.0 × 10-5). Conclusion: These findings provide insight into the genetic basis of body composition in Tibetan college students adapted to HA, and lay the foundation for further investigation into the molecular mechanisms underlying HA adaptation.