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OBJECTIVES: The Tower of London - Freiburg version (TOL-F) was developed in three parallel-test versions (A, B, and C) that only differ in their physical appearance by interchanged ball colors, but not in their cognitive demands. We addressed the question whether the test-retest reliability of an identical problem set differs from the parallel test-retest reliability of a structurally identical problem set with a marginally different physical appearance. METHODS: Reliabilities were assessed in two samples of young adults over a 1-week interval: In the parallel test-retest sample (n = 93; 49 female), half of the participants accomplished version A at the first session and version B at the second session, while the other half started with version B in the first session and continued with A in the second session. In the identical test-retest sample (n = 86; 48 female), half of the participants performed on version A in both the first and the second session, while the other half went through the same procedure with version B. RESULTS: For overall planning accuracy, intraclass correlation coefficients for absolute agreement were r = .501 for the parallel test-retest and r = .605 for the identical test-retest sample, with Pearson correlations of r = .559 and r = .708 respectively. Greatest lower bound estimates of reliability were adequate to high in the two samples (ranging between .765 and .854) confirming previous studies. CONCLUSIONS: Although the TOL-F revealed only moderate intraclass correlations for absolute agreement, it showed some of the highest psychometric indices compared to repeated assessments with other TOL tests.
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Reproducibilidad de los Resultados , Adulto Joven , Humanos , Femenino , Pruebas Neuropsicológicas , PsicometríaRESUMEN
Procedural knowledge space theory (PKST) was recently proposed by Stefanutti (British Journal of Mathematical and Statistical Psychology, 72(2) 185-218, 2019) for the assessment of human problem-solving skills. In PKST, the problem space formally represents how a family of problems can be solved and the knowledge space represents the skills required for solving those problems. The Markov solution process model (MSPM) by Stefanutti et al. (Journal of Mathematical Psychology, 103, 102552, 2021) provides a probabilistic framework for modeling the solution process of a task, via PKST. In this article, three adaptive procedures for the assessment of problem-solving skills are proposed that are based on the MSPM. Beside execution correctness, they also consider the sequence of moves observed in the solution of a problem with the aim of increasing efficiency and accuracy of assessments. The three procedures differ from one another in the assumption underlying the solution process, named pre-planning, interim-planning, and mixed-planning. In two simulation studies, the three adaptive procedures have been compared to one another and to the continuous Markov procedure (CMP) by Doignon and Falmagne (1988a). The last one accounts for dichotomous correct/wrong answers only. Results show that all the MSP-based adaptive procedures outperform the CMP in both accuracy and efficiency. These results have been obtained in the framework of the Tower of London test but the procedures can also be applied to all psychological and neuropsychological tests that have a problem space. Thus, the adaptive procedures presented in this paper pave the way to the adaptive assessment in the area of neuropsychological tests.
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Algoritmos , Solución de Problemas , Humanos , Matemática , Simulación por Computador , Cadenas de Markov , Pruebas NeuropsicológicasRESUMEN
Travel planning (TP) is a kind of planning devoted to spatial orientation that is distinguishable from general planning (GP). It is crucial to reach a destination, since it allows to select the best route according to the environmental features (e.g., the one with little traffic or the safest). TP is also needed to avoid obstacles along the way and to put in place effective strategies to support navigation. TP involves several cognitive processes, such as visuo-spatial and topographic memory as well as other executive functions (i.e., general planning, cognitive flexibility, problem solving, and divergent thinking) and it is affected by internal factors (such as gender, cognitive strategies, age). Here, we focused on the effects of visuo-spatial (VSWM) and topographic (TWM) working memory on TP, using the Minefield Task (MFT), a new tool aimed at testing TP. We tested VSWM, TWM, GP, and TP in 44 college students. First, we checked for gender differences in all the tasks proposed and then assessed the relation among VSWM, TWM, GP, and TP. Results showed that even though gender difference could be found on TWM, GP, and TP, significative correlations emerged among TP, VSWM, and GP as well as a tendency to significance for VSWM and GP in the regression analyses. Though more evidence is needed, these results suggest that when a brand-new route is computed, GP and VSWM can be the most relevant processes, whereas topographic memory was less involved, probably because the MFT does not require to recall a route from memory. The implications of these results in clinical settings are discussed.
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Memoria a Corto Plazo , Recuerdo Mental , Viaje , Función Ejecutiva , Humanos , Percepción EspacialRESUMEN
Tower of London (ToL) is a neuropsychological method for assessing planning ability. In this study, we attempted to introduce a shorter version of ToL. Two studies were carried out. In Study 1, patients with mild cognitive impairment due to Parkinson's Disease (n = 36) and a control group (n = 225) were included in order to select a suitable short version of ToL for Study 2. In Study 2, patients with schizophrenia (n = 30) and a control group (n = 31) were included in order to assess psychometric properties of the shortened version of ToL. Based on psychometric evaluations in Study 1, we offered three possible shortened versions. In Study 2, all three shortened versions proved to have good discriminative validity in our schizophrenia sample, but interestingly not in the healthy sample. We concluded that the use of shortened ToL is possible in specific psychiatric/neurological patient groups, although we do not recommend doing so in healthy individuals.
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Disfunción Cognitiva , Función Ejecutiva , Disfunción Cognitiva/diagnóstico , Disfunción Cognitiva/etiología , Humanos , Pruebas Neuropsicológicas , Solución de Problemas , PsicometríaRESUMEN
Perceived loneliness has implications in both cognitive and affective domains. High loneliness is considered to be a major risk factor for major depressive disorder. Loneliness is also associated with impaired executive control functioning (ECF) including multiple cognitive subdomains, such as working memory, planning, response inhibition, and attention control. However, little knowledge exists as to whether perceived loneliness is associated with impaired functioning of specific ECF components. The relationship between perceived loneliness and the latent dimensions capturing multiple measures across different ECF paradigms has not been established. In this study, we first investigated the latent dimensions of ECF processes across a comprehensive range of paradigms using exploratory factor analysis. We then examined the association of perceived loneliness and the resulted ECF components in older adults while simultaneously controlling for other demographic and affective measures. Four components emerged from the factor analysis: social cognition and processing speed, planning and working memory, selective, divided attention and inhibition control, and sustained attention and motor inhibition. We observed that the second ECF component, planning and working memory, was a significant predictor of perceived loneliness even after controlling for depressive characteristics measured by the Geriatric Depression Scale. Our findings have potential clinical significance in the older population, by showing that planning and working memory functions may predict perceived loneliness, which is also associated with higher risk for major depression. Thus, older individuals who have lower planning and working memory functions may be specifically targeted for possible early prevention of chronic loneliness and depression.
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Disfunción Cognitiva , Trastorno Depresivo Mayor , Anciano , Cognición , Función Ejecutiva , Humanos , SoledadRESUMEN
OBJECTIVES: The Tower of London (TOL) test has probably become the most often used task to assess planning ability in clinical and experimental settings. Since its implementation, efforts were made to provide a task version with adequate psychometric properties, but extensive normative data are not publicly available until now. The computerized TOL-Freiburg Version (TOL-F) was developed based on theory-grounded task analyses, and its psychometric adequacy has been repeatedly demonstrated in several studies but often with small and selective samples. METHOD: In the present study, we now report reliability estimates and normative data for the TOL-F stratified for age, sex, and education from a large population-representative sample collected in the Gutenberg Health Study in Mainz, Germany (n=7703; 40-80 years). RESULTS: The present data confirm previously reported adequate indices of reliability (>.70) of the TOL-F. We also provide normative data for the TOL-F stratified for age (5-year intervals), sex, and education (low vs. high education). CONCLUSIONS: Together, its adequate reliability and the representative age-, sex-, and education-fair normative data render the computerized TOL-F a suitable diagnostic instrument to assess planning ability. (JINS, 2019, 25, 520-529).
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Función Ejecutiva/fisiología , Desarrollo Humano/fisiología , Pruebas Neuropsicológicas/estadística & datos numéricos , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Cohortes , Femenino , Alemania , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Reproducibilidad de los ResultadosRESUMEN
Childhood is a critical period for the development of cognitive planning. There is a lack of knowledge on its neural mechanisms in children. This study aimed to examine cerebello-cortical and cortico-cortical functional connectivity in association with planning skills in 6-year-olds (nâ¯=â¯76). We identified the cerebello-cortical and cortico-cortical functional networks related to cognitive planning using activation likelihood estimation (ALE) meta-analysis on existing functional imaging studies on spatial planning, and data-driven independent component analysis (ICA) of children's resting-state functional MRI (rs-fMRI). We investigated associations of cerebello-cortical and cortico-cortical functional connectivity with planning ability in 6-year-olds, as assessed using the Stockings of Cambridge task. Long-range functional connectivity of two cerebellar networks (lobules VI and lateral VIIa) with the prefrontal and premotor cortex were greater in children with poorer planning ability. In contrast, cortico-cortical association networks were not associated with the performance of planning in children. These results highlighted the key contribution of the lateral cerebello-frontal functional connectivity, but not cortico-cortical association functional connectivity, for planning ability in 6-year-olds. Our results suggested that brain adaptation to the acquisition of planning ability during childhood is partially achieved through the engagement of the cerebello-cortical functional connectivity.
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Cerebelo/fisiología , Corteza Cerebral/fisiología , Desarrollo Infantil/fisiología , Conectoma/métodos , Función Ejecutiva/fisiología , Red Nerviosa/fisiología , Desempeño Psicomotor/fisiología , Cerebelo/diagnóstico por imagen , Corteza Cerebral/diagnóstico por imagen , Niño , Humanos , Imagen por Resonancia MagnéticaRESUMEN
Recent evidence suggests that the cerebellum contributes not only to the planning and execution of movement but also to the high-order cognitive planning. Childhood is a critical period for development of the cerebellum and cognitive planning. This study aimed (a) to examine the development of cerebellar morphology and microstructure and (b) to examine the cerebellar mediation roles in the relationship between age and cognitive planning in 6- to 10-year-old children (n = 126). We used an anatomical parcellation to quantify cerebellar regional gray matter (GM) and white matter (WM) volumes, and WM microstructure, including fractional anisotropy (FA) and mean diffusivity (MD). We assessed planning ability using the Stockings of Cambridge (SOC) task in all children. We revealed (a) a measure-specific anterior-to-posterior gradient of the cerebellar development in childhood, that is, smaller GM volumes and greater WM FA of the anterior segment of the cerebellum but larger GM volumes and lower WM FA in the posterior segment of the cerebellum in older children; (b) an age-related improvement of the SOC performance at the most demanding level of five-move problems; and (c) a mediation role of the lateral cerebellar WM volumes in age-related improvement in the SOC performance in childhood. These results highlight the differential development of the cerebellum during childhood and provide evidence that brain adaptation to the acquisition of planning ability during childhood could partially be achieved through the engagement of the lateral cerebellum.
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Cerebelo , Desarrollo Infantil/fisiología , Función Ejecutiva/fisiología , Sustancia Gris , Sustancia Blanca , Cerebelo/anatomía & histología , Cerebelo/diagnóstico por imagen , Cerebelo/crecimiento & desarrollo , Niño , Imagen de Difusión Tensora , Femenino , Sustancia Gris/anatomía & histología , Sustancia Gris/diagnóstico por imagen , Sustancia Gris/crecimiento & desarrollo , Humanos , Masculino , Sustancia Blanca/anatomía & histología , Sustancia Blanca/diagnóstico por imagen , Sustancia Blanca/crecimiento & desarrolloRESUMEN
BACKGROUND: Major depression and anxiety disorders are known to negatively influence cognitive performance. Moreover, there is evidence for greater cognitive decline in older adults with generalized anxiety disorder. Except for clinical studies, complex executive planning functions and subclinical levels of anxiety have not been examined in a population-based sample with a broad age range. METHODS: Planning performance was assessed using the Tower of London task in a population-based sample of 4240 participants aged 40-80 years from the Gutenberg Health Study (GHS) and related to self-reported anxiety and depression by means of multiple linear regression analysis. RESULTS: Higher anxiety ratings were associated with lower planning performance (ß = -0.20; p < 0.0001) independent of age (ß = 0.03; p = 0.47). When directly comparing the predictive value of depression and anxiety on cognition, only anxiety attained significance (ß = -0.19; p = 0.0047), whereas depression did not (ß = -0.01; p = 0.71). CONCLUSIONS: Subclinical levels of anxiety but not of depression showed negative associations with cognitive functioning independent of age. Our results demonstrate that associations observed in clinical groups might differ from those in population-based samples, also with regard to the trajectory across the life span. Further studies are needed to uncover causal interrelations of anxiety and cognition, which have been proposed in the literature, in order to develop interventions aimed at reducing this negative affective state and to improve executive functioning.
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Ansiedad/complicaciones , Ansiedad/psicología , Disfunción Cognitiva/fisiopatología , Pruebas Neuropsicológicas , Anciano , Cognición , Disfunción Cognitiva/etiología , Estudios Transversales , Depresión/psicología , Función Ejecutiva , Femenino , Alemania , Humanos , Modelos Lineales , Masculino , Persona de Mediana Edad , Solución de Problemas , Estudios Prospectivos , Desempeño PsicomotorRESUMEN
The ability to mentally design and evaluate series of future actions has often been studied in terms of planning abilities, commonly using well-structured laboratory tasks like the Tower of London (ToL). Despite a wealth of studies, findings on the specific localization of planning processes within prefrontal cortex (PFC) and on the hemispheric lateralization are equivocal. Here, we address this issue by integrating evidence from two different sources of data: First, we provide a systematic overview of the existing lesion data on planning in the ToL (10 studies, 211 patients) which does not indicate any evidence for a general lateralization of planning processes in (pre)frontal cortex. Second, we report a quantitative meta-analysis with activation likelihood estimation based on 31 functional neuroimaging datasets on the ToL. Separate meta-analyses of the activation patterns reported for Overall Planning (537 participants) and for Planning Complexity (182 participants) congruently show bilateral contributions of mid-dorsolateral PFC, frontal eye fields, supplementary motor area, precuneus, caudate, anterior insula, and inferior parietal cortex in addition to a left-lateralized involvement of rostrolateral PFC. In contrast to previous attributions of planning-related brain activity to the entire dorsolateral prefrontal cortex (dlPFC) and either its left or right homolog derived from single studies on the ToL, the present meta-analyses stress the pivotal role specifically of the mid-dorsolateral part of PFC (mid-dlPFC), presumably corresponding to Brodmann Areas 46 and 9/46, and strongly argue for a bilateral rather than lateralized involvement of the dlPFC in planning in the ToL. Hum Brain Mapp 38:396-413, 2017. © 2016 Wiley Periodicals, Inc.
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Encéfalo/diagnóstico por imagen , Encéfalo/fisiología , Funciones de Verosimilitud , Neuroimagen , Pruebas Neuropsicológicas , Solución de Problemas/fisiología , Mapeo Encefálico , Lateralidad Funcional , Humanos , Procesamiento de Imagen Asistido por Computador , PubMed/estadística & datos numéricosRESUMEN
BACKGROUND: Despite a large body of research on planning performance in adult schizophrenia patients, results of individual studies are equivocal, suggesting either no, moderate or severe planning deficits. This meta-analysis therefore aimed to quantify planning deficits in schizophrenia and to examine potential sources of the heterogeneity seen in the literature. METHOD: The meta-analysis comprised outcomes of planning accuracy of 1377 schizophrenia patients and 1477 healthy controls from 31 different studies which assessed planning performance using tower tasks such as the Tower of London, the Tower of Hanoi and the Stockings of Cambridge. A meta-regression analysis was applied to assess the influence of potential moderator variables (i.e. sociodemographic and clinical variables as well as task difficulty). RESULTS: The findings indeed demonstrated a planning deficit in schizophrenia patients (mean effect size: ; 95% confidence interval 0.56-0.78) that was moderated by task difficulty in terms of the minimum number of moves required for a solution. The results did not reveal any significant relationship between the extent of planning deficits and sociodemographic or clinical variables. CONCLUSIONS: The current results provide first meta-analytic evidence for the commonly assumed impairments of planning performance in schizophrenia. Deficits are more likely to become manifest in problem items with higher demands on planning ahead, which may at least partly explain the heterogeneity of previous findings. As only a small fraction of studies reported coherent information on sample characteristics, future meta-analyses would benefit from more systematic reports on those variables.
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Disfunción Cognitiva/fisiopatología , Función Ejecutiva/fisiología , Desempeño Psicomotor/fisiología , Esquizofrenia/fisiopatología , Disfunción Cognitiva/etiología , Humanos , Esquizofrenia/complicacionesRESUMEN
Deficit in planning and problem-solving, affecting a wide range of neuropsychological patients, has been widely investigated using the Tower of London (ToL) test, as developed by Shallice (Philos Trans R Soc Lond Ser B Biol Sci 298:199-209, 1). The ToL taps on several executive functions (EF), such as planning, time for planning or rule breaks, which may be usefully indexed by different ToL measurements. However, in its original version, the different aspects involved in ToL are not evaluated in a specific way.Here, we report the standardization of the ToL, on 896 individuals aged 15-86 years, taking in account individual factors (i.e. gender, age, years of education) which may affect performances on ToL. We computed several indexes on the ToL including score, planning and execution times, perseverations, rule breaks and self-monitoring. We found that these indexes were affected by individual factors such as gender, age and education. Present results not only provide extensive normative data according to gender, as well as different age and education ranges, but also represent a very useful instrument for a more fine-grained diagnosis of EF deficits in a wide range of neuropsychological patients, including traumatic brain injury and brain-damaged patients, as well as Alzheimer's disease and Parkinson's disease patients.
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Cognición/fisiología , Función Ejecutiva/fisiología , Pruebas Neuropsicológicas/normas , Solución de Problemas/fisiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Enfermedad de Alzheimer/fisiopatología , Lesiones Encefálicas/fisiopatología , Femenino , Humanos , Italia , Masculino , Persona de Mediana Edad , Adulto JovenRESUMEN
Sub-domains of executive functions, including problems with planning, accuracy, impulsivity, and inhibition, are core features of Huntington's disease. It is known that the decline of cognitive function in Huntington's disease is related to the anatomical progression of pathology in the basal ganglia. However, it remains to be determined whether the severity of executive dysfunction depends on the stage of the disease. To examine the severity of sub-domains of executive dysfunction in early- and late-stage Huntington's disease, we studied performance in the Tower of London task of two groups of Huntington's disease patients (Group 1: early, n = 23, and Group 2: late stage, n = 29), as well as a third group of age, education, and IQ matched healthy controls (n = 34). During the task, we measured the total number of problems solved, total planning time, and total number of breaks taken. One aspect of executive function indexed by the number of solved problems seems to progress in the course of the disease. Late-stage Huntington's disease patients scored significantly worse than early-stage patients and controls, and early-stage patients scored significantly worse than controls on this measure of accuracy. In contrast, late- and early-stage HD patients did not differ in terms of planning time and number of breaks. Early- and late-stage HD pathology has a different impact on executive sub-domains. While accuracy differs between early- and late-stage HD patients, other domains like planning time and number of breaks do not. Striatal degeneration, which is a characteristic feature of the disease, might not affect all aspects of executive function in HD.
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Disfunción Cognitiva/fisiopatología , Función Ejecutiva/fisiología , Enfermedad de Huntington/fisiopatología , Conducta Impulsiva/fisiología , Inhibición Psicológica , Solución de Problemas/fisiología , Adulto , Anciano , Disfunción Cognitiva/etiología , Femenino , Humanos , Enfermedad de Huntington/complicaciones , Masculino , Persona de Mediana Edad , Índice de Severidad de la EnfermedadRESUMEN
Successfully generating plans, while seemingly straightforward, can be riddled with external and internal interferences. One important possible source of interference is ostracism, which has been consistently shown to induce negative psychological effects in various executive functions. Therefore, understanding the impact of unforeseen ostracism on planning is vital to a broad spectrum of the population, from university students, whose self-esteem partly derives from social acceptance, to healthcare professionals, whose performance oftentimes relies on peer feedback. An individual's ability to navigate through intended actions is an evaluation of their prospective memory (PM), which is traditionally divided into three consecutive phases: (1) planning, (2) recall, and (3) performance. This study primarily focused on the impacts of ostracism via Cyberball simulation on the first two phases of PM in the Tower of London (TOL), an assessment of executive functioning designed specifically to test planning ability during problem solving. Using Bayesian analysis, the study found substantial evidence of there being no difference in planning success between social exclusion and inclusion conditions. However, an individual's sex had significant effects on their planning success at baseline (i.e., inclusion condition). Surprisingly, there was no difference in performance between male participants and female participants when excluded, suggesting that ostracism may play an equalizing role. In addition, male participants both listed more moves at planning and recalled more moves, which led to no difference between sexes in terms of recall percentage. This study underscores a need to consider various factors such as sex and differing perceptions of ostracism when analyzing and addressing problem solving performance.
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The Tower of London, Drexel Version, Second Edition (TOL-DX) is purported to measure multiple aspects of executive functions, although it also possesses inherent non-executive demands. Such complexity makes it useful in detecting impairment but difficult in interpreting the neurocognitive cause of impairment, particularly in children. This study investigated the developmental, neurocognitive, and symptom correlates of the TOL-DX in children and adolescents with neuropsychiatric disorders. Two-hundred and thirty-three children and adolescents (7-21 years old) completed the TOL-DX during a neuropsychological evaluation as part of clinical care within a children's psychiatric hospital. Pearson correlation, regression models, and receiver operating characteristic curve (ROC) analyses examined the association among variables. Visuospatial and executive functions (EF) were most consistently related to total moves, execution time, and violations. TOL-DX variables were associated with attention in younger participants and EF in older participants. No TOL-DX scores were related to parent-reported symptoms. The TOL-DX possesses inherent visuospatial and attention/executive demands in children and adolescents which are difficult to differentiate, differ by age group, and not associated to clinical symptoms. Taken together, the TOL-DX is complex to interpret, but psychometrically sound and sensitive to neurocognitive impairment in children and adolescents with transdiagnostic neuropsychiatric disorders.
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OBJECTIVE: This study compares executive functioning in deaf children with cochlear implants and those with normal hearing. Individuals who lacked auditory stimulation during their early years might experience cognitive challenges that extend beyond just speech and language abilities. METHODS: The executive functioning abilities of a group of 32 children who were born deaf and received cochlear implants before the age of 7 were contrasted with those of 30 children with normal hearing. Both sets of children underwent assessments using the Tower of London, BRIEF, and Stroop tests. RESULTS: The average score on the Tower of London task reveals that children who received cochlear implants (4.03 ± 2.53) achieved lower scores than typically hearing children (8.37 ± 2.79). This group also exhibited higher errors in the Stroop test and slightly longer response times Additionally, in terms of emotional control assessed by the BRIEF, a higher score was recorded. Notably, significant differences between the two groups were identified for organizing materials (t(62) = -4.204, p = 0.00). The tests measuring phonemic fluency, categorical fluency, and working memory also revealed significant differences. CONCLUSIONS: The significant differences in data between both groups suggest the influence of cochlear implantation on cognitive functions. This emphasizes the importance of a holistic approach to supporting the overall development of these children.
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Implantación Coclear , Implantes Cocleares , Sordera , Función Ejecutiva , Humanos , Niño , Implantes Cocleares/psicología , Masculino , Femenino , Sordera/cirugía , Sordera/psicología , Irán , Estudios de Casos y Controles , Cognición , Test de Stroop , Memoria a Corto PlazoRESUMEN
Increasing studies have observed the benefit of acute exercise on core executive functions (EFs). However, the effects of high-order EFs (i.e., metacognition) are poorly investigated. Additionally, the beneficial effect varies depending on exercise-related variables (e.g., intensity, duration). Exercise volume, represented by exercise intensity and duration, is one approach to examine the relationship between acute exercise and metacognition. Therefore, this study aims to investigate the effects of acute exercise, involving three volume-matched evaluations, on metacognition in late middle-aged adults. It recruited 40 community-dwelling late middle-aged adults (22 females; Mage=61.05±4.17years). Its counterbalanced and repeated-measure experimental design included a control reading session and three exercise sessions: (1) acute moderate-intensity exercise for 30min, (2) higher-intensity exercise for 16min, and (3) lower-intensity exercise for 40min. After each session, all participants were asked to perform the Tower of London (TOL) task to assess their metacognition related to planning and problem-solving. This study showed that regardless of exercise intensity and duration variation, acute exercise led to higher move-related (i.e., total correct and move scores) and time-related (i.e., total executive and problem-solving times) scores but did not affect total initial time and violation-related scores compared to reading treatment. These findings suggest enhanced performance in metacognition after acute exercise regardless of its intensity and duration variation.
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Metacognición , Adulto , Persona de Mediana Edad , Femenino , Humanos , Ejercicio Físico , Función EjecutivaRESUMEN
(1) Background: Traumatic brain injury (TBI) often results in cognitive impairments, including in visuospatial planning and executive function. Methylphenidate (MPh) demonstrates potential improvements in several cognitive domains in patients with TBI. The Tower of London (TOL) is a visuospatial planning task used to assess executive function. (2) Methods: Volunteers with a history of TBI (n = 16) participated in a randomised, double-blinded, placebo-controlled, fMRI study to investigate the neurobiological correlates of visuospatial planning and executive function, on and off MPh. (3) Results: Healthy controls (HCs) (n = 18) and patients on placebo (TBI-placebo) differed significantly in reaction time (p < 0.0005) and accuracy (p < 0.0001) when considering all task loads, but especially for high cognitive loads for reaction time (p < 0.001) and accuracy (p < 0.005). Across all task loads, TBI-MPh were more accurate than TBI-placebo (p < 0.05) but remained less accurate than HCs (p < 0.005). TBI-placebo substantially improved in accuracy with MPh administration (TBI-MPh) to a level statistically comparable to HCs at low (p = 0.443) and high (p = 0.175) cognitive loads. Further, individual patients that performed slower on placebo at low cognitive loads were faster with MPh (p < 0.05), while individual patients that performed less accurately on placebo were more accurate with MPh at both high and low cognitive loads (p < 0.005). TBI-placebo showed reduced activity in the bilateral inferior frontal gyri (IFG) and insulae versus HCs. MPh normalised these regional differences. MPh enhanced within-network connectivity (between parietal, striatal, insula, and cerebellar regions) and enhanced beyond-network connectivity (between parietal, thalamic, and cerebellar regions). Finally, individual changes in cerebellar-thalamic (p < 0.005) and cerebellar-parietal (p < 0.05) connectivity with MPh related to individual changes in accuracy with MPh. (4) Conclusions: This work highlights behavioural and neurofunctional differences between HCs and patients with chronic TBI, and that adverse differences may benefit from MPh treatment.
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Mate Marote is an open-access cognitive training software aimed at children between 4 and 8 years old. It consists of a set of computerized games specifically tailored to train and evaluate Executive Functions (EF), a class of processes critical for purposeful, goal-directed behavior, including working memory, planning, flexibility, and inhibitory control. Since 2008, several studies were performed with this software at children's own schools in interventions supervised in-person by cognitive scientists. After 2015, we incorporated naturalistic, yet controlled, interventions with children's own teachers' help. The platform includes a battery of standardized tests, disguised as games, to assess children's EF. The main question that emerges is whether the results, obtained with these traditional tasks but conducted without the presence of researchers, are comparable to those widely reported in the literature, that were obtained in more supervised settings. In this study, we were able to replicate the expected difficulty and age effects in at least one of the analyzed dependent variables of each employed test. We also report important discrepancies between the expected and the observed response time patterns, specifically for time-constrained tasks. We hereby discuss the benefits and setbacks of a new possible strategy for this type of assessment in naturalistic settings. We conclude that this battery of established EF tasks adapted for its remote usage is appropriate to measure the expected mental processes in naturalistic settings, enriching opportunities to upscale cognitive training interventions at schools. These types of tools can constitute a concerted strategy to bring together educational neuroscience research and real-life practice.
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The Tower of London (ToL) is a neuropsychological test used to assess several executive functions such as strategical reasoning, mental planning, and problem-solving. Like other cognitive tests, performance on the ToL can vary according to age, level of education, sex, and cultural background of individuals. The present study aimed to establish normative data for the Drexel version of the ToL among French-Quebec people aged 50 years and over. The normative sample consisted of 174 healthy individuals aged 50-88 years, all from the province of Quebec, Canada. Analyses were performed to estimate the associations between age, sex, and education level on one hand, and ToL performance, on the other hand. Results indicated that Total Execution Time was associated with age, whereas the Total Type II Errors and Total Rule Violation score (Type I + II Errors) were associated with both age and education level. All other scores were not significantly associated with the demographic characteristics of the participants. Since the distributions of the data were all skewed, the normative data are presented in the form of percentile ranks. To conclude, the present norms will ease the detection of executive impairments in French-Quebec middle-aged and older adults.