Assessment of Panorama Photogrammetry as a Tool for Long-Range Deformation Monitoring.

This study investigates panorama photogrammetry (PPh) as a potential method to collect massive 3D information for long-range deformation monitoring. Particularly, this study focuses on areas with measuring restrictions, i.e., inaccessible objects and distances above 0.6 km. Under these particular conditions, geodetic techniques based on Electromagnetic Distance Meters (EDMs) or Total Stations (TSs) can provide coordinates with a precision better than 1 cm, but only for a limited number of discrete points. For mass capture, Terrestrial Laser Scanning (TLS) is normally the preferred solution, but long-range instruments are expensive, and drawbacks such as weak return signals and non-automatic target recognition appear. As an alternative, PPh is investigated in the well-controlled area of La Muela in Cortes de Pallas, where images are automatically captured from geodetic pillars using a GigaPan device, processed, and then rigorously compared to TLS point clouds. The results obtained after integrating both techniques into a high-accuracy geodetic reference frame show that PPh and TLS provide similar precision to within approximately 4 cm in the range of 0.6-1.0 km. Therefore, considering cost-effectiveness and ease of use, the proposed method can be considered a low-cost alternative to TLS for long-range deformation monitoring.

Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome.

BACKGROUND: Nibrin, as part of the NBN/MRE11/RAD50 complex, is mutated in Nijmegen breakage syndrome (NBS), which leads to impaired DNA damage response and lymphoid malignancy. RESULTS: Telomere length (TL) was markedly reduced in homozygous patients (and comparably so in all chromosomes) by ~40% (qPCR) and was slightly reduced in NBS heterozygotes older than 30 years (~25% in qPCR), in accordance with the respective cancer rates. Humanized cancer-free NBS mice had normal TL. Telomere elongation was inducible by telomerase and/or alternative telomere lengthening but was associated with abnormal expression of telomeric genes involved in aging and/or cell growth. Lymphoblastoid cells from NBS patients with long survival times (>12 years) displayed the shortest telomeres and low caspase 7 activity. CONCLUSIONS: NBS is a secondary telomeropathy. The two-edged sword of telomere attrition enhances the cancer-prone situation in NBS but can also lead to a relatively stable cellular phenotype in tumor survivors. Results suggest a modular model for progeroid syndromes with abnormal expression of telomeric genes as a molecular basis. METHODS: We studied TL and function in 38 homozygous individuals, 27 heterozygotes, one homozygous fetus, six NBS lymphoblastoid cell lines, and humanized NBS mice, all with the same founder NBN mutation: c.657_661del5.

Rhabdomyolysis and exercise-associated hyponatremia in ultra-bikers and ultra-runners.

BACKGROUND: Exercise-associated hyponatremia (EAH), rhabdomyolysis and renal failure appear to be a unique problem in ultra-endurance racers. METHODS: We investigated the combined occurrence of EAH and rhabdomyolysis in seven different ultra-endurance races and disciplines (i.e. multi-stage mountain biking, 24-h mountain biking, 24-h ultra-running and 100-km ultra-running). RESULTS: Two (15.4%) ultra-runners (man and woman) from hyponatremic ultra-athletes (n = 13) and four (4%) ultra-runners (four men) from the normonatremic group (n = 100) showed rhabdomyolysis following elevated blood creatine kinase (CK) levels > 10,000 U/L without the development of renal failure and the necessity of a medical treatment. Post-race creatine kinase, plasma and urine creatinine significantly increased, while plasma [Na(+)] and creatine clearance decreased in hyponatremic and normonatremic athletes, respectively. The percentage increase of CK was higher in the hyponatremic compared to the normonatremic group (P < 0.05). Post-race CK levels were higher in ultra-runners compared to mountain bikers (P < 0.01), in faster normonatremic (P < 0.05) and older and more experienced hyponatremic ultra-athletes (P < 0.05). In all finishers, pre-race plasma [K(+)] was related to post-race CK (P < 0.05). CONCLUSIONS: Hyponatremic ultra-athletes tended to develop exercise-induced rhabdomyolysis more frequently than normonatremic ultra-athletes. Ultra-runners tended to develop rhabdomyolysis more frequently than mountain bikers. We found no association between post-race plasma [Na(+)] and CK concentration in both hypo- and normonatremic ultra-athletes.