Identification of drug-side effect association via restricted Boltzmann machines with penalized term.

In the entire life cycle of drug development, the side effect is one of the major failure factors. Severe side effects of drugs that go undetected until the post-marketing stage leads to around two million patient morbidities every year in the United States. Therefore, there is an urgent need for a method to predict side effects of approved drugs and new drugs. Following this need, we present a new predictor for finding side effects of drugs. Firstly, multiple similarity matrices are constructed based on the association profile feature and drug chemical structure information. Secondly, these similarity matrices are integrated by Centered Kernel Alignment-based Multiple Kernel Learning algorithm. Then, Weighted K nearest known neighbors is utilized to complement the adjacency matrix. Next, we construct Restricted Boltzmann machines (RBM) in drug space and side effect space, respectively, and apply a penalized maximum likelihood approach to train model. At last, the average decision rule was adopted to integrate predictions from RBMs. Comparison results and case studies demonstrate, with four benchmark datasets, that our method can give a more accurate and reliable prediction result.

Online learning resource recommendation method based on multi-similarity metric optimization under the COVID-19 epidemic.

With the continuous COVID-19 pneumonia epidemic, online learning has become a normal choice for many learners. However, the problems of information overload and knowledge maze have been aggravated in the process of online learning. A learning resource recommendation method based on multi similarity measure optimization is proposed in this paper. We optimize the user score similarity by introducing information entropy, and use particle swarm optimization algorithm to determine the comprehensive similarity weight, and determine the nearest neighbor user with both score similarity and interest similarity through secondary screening in this method. The ultimate goal is to improve the accuracy of recommendation results, and help learners learn more effectively. We conduct experiments on public data sets. The experimental results show that the algorithm in this paper can significantly improve the recommendation accuracy on the basis of maintaining a stable recommendation coverage.

iCDA-CMG: identifying circRNA-disease associations by federating multi-similarity fusion and collective matrix completion.

Circular RNAs (circRNAs) are a special class of non-coding RNAs with covalently closed-loop structures. Studies prove that circRNAs perform critical roles in various biological processes, and the aberrant expression of circRNAs is closely related to tumorigenesis. Therefore, identifying potential circRNA-disease associations is beneficial to understand the pathogenesis of complex diseases at the circRNA level and helps biomedical researchers and practitioners to discover diagnostic biomarkers accurately. However, it is tremendously laborious and time-consuming to discover disease-related circRNAs with conventional biological experiments. In this study, we develop an integrative framework, called iCDA-CMG, to predict potential associations between circRNAs and diseases. By incorporating multi-source prior knowledge, including known circRNA-disease associations, disease similarities and circRNA similarities, we adopt a collective matrix completion-based graph learning model to prioritize the most promising disease-related circRNAs for guiding laborious clinical trials. The results show that iCDA-CMG outperforms other state-of-the-art models in terms of cross-validation and independent prediction. Moreover, the case studies for several representative cancers suggest the effectiveness of iCDA-CMG in screening circRNA candidates for human diseases, which will contribute to elucidating the pathogenesis mechanisms and unveiling new opportunities for disease diagnosis and targeted therapy.

RWSF-BLP: a novel lncRNA-disease association prediction model using random walk-based multi-similarity fusion and bidirectional label propagation.

An increasing number of studies and experiments have demonstrated that long noncoding RNAs (lncRNAs) have a massive impact on various biological processes. Predicting potential associations between lncRNAs and diseases not only can improve our understanding of the molecular mechanisms of human diseases but also can facilitate the identification of biomarkers for disease diagnosis, treatment, and prevention. However, identifying such associations through experiments is costly and demanding, thereby prompting researchers to develop computational methods to complement these experiments. In this paper, we constructed a novel model called RWSF-BLP (a novel lncRNA-disease association prediction model using Random Walk-based multi-Similarity Fusion and Bidirectional Label Propagation), which applies an efficient random walk-based multi-similarity fusion (RWSF) method to fuse different similarity matrices and utilizes bidirectional label propagation to predict potential lncRNA-disease associations. Leave-one-out cross-validation (LOOCV) and 5-fold cross-validation (5-fold-CV) were implemented in the evaluation RWSF-BLP performance. Results showed that, RWSF-BLP has reliable AUCs of 0.9086 and 0.9115 ± 0.0044 under the framework of LOOCV and 5-fold-CV and outperformed other four canonical methods. Case studies on lung cancer and leukemia demonstrated that potential lncRNA-disease associations can be predicted through our method. Therefore, our method can accurately infer potential lncRNA-disease associations and may be a good choice in future biomedical research.