Tissue Doppler ultrasound of arm muscles to assess myotonia in myotonic dystrophies: An exploratory study.

INTRODUCTION/AIMS: Myotonia is a key symptom of myotonic dystrophies (DM), and its quantification is challenging. This exploratory study evaluated the utility of tissue Doppler ultrasound (TDU) to assess myotonia in DM. METHODS: Twelve DM patients (seven type-1 DM [DM1] and five type-2 DM [DM2]) and 20 age-matched healthy subjects were included in this cross-sectional study. After measuring cross-sectional areas of the flexor digitorum superficialis (FDS) and extensor digitorum communis (EDC) muscles in a resting state, muscle contraction/relaxation time, time to peak tissue velocity, peak tissue velocity and velocity gradients of these muscles were measured via TDU while performing forced fist unclenching after fist closure. Additionally, grip strength, Medical Research Council Sum score and patient-reported myotonia severity scores were assessed. RESULTS: DM1 and DM2 patients had a lower grip strength than healthy subjects (p = .0001/p = .002). Patient-reported myotonia did not differ between DM1 and DM2 patients. DM1 patients revealed FDS and EDC atrophy compared to DM2 patients and healthy subjects (p = .003/p = .004). TDU revealed prolonged muscle contraction and relaxation times in both DM subtypes, with prolonged time to reach FDS peak relaxation velocity and altered peak FDS relaxation velocity only in DM1 patients (p = .03/p = .003). Peak FDS relaxation velocity correlated inversely with C(C)TG repeat numbers in DM patients. Sensitivity of TDU parameters to detect myotonic dystrophy varied between 50% and 75%, with a specificity of 95%. DISCUSSION: Our exploratory study suggests that TDU could serve as a novel tool to quantify myotonia in DM patients, but larger follow-up studies are warranted to validate its diagnostic accuracy.

Velocity Vector Estimation of Two-Dimensional Flow Field Based on STIV.

As an important part of hydrometry, river discharge monitoring plays an irreplaceable role in the planning and management of water resources and is an essential element and necessary means of river management. Due to its benefits of simplicity, efficiency and safety, Space-Time Image Velocimetry (STIV) has attracted attention from all around the world. The most crucial component of the STIV is the detection of the Main Orientation of Texture (MOT), and the precision of detection directly affects the results of calculations. However, due to the complicated river flow characteristics and the harsh testing environment in the field, a large amount of noise and interfering textures show up in the space-time images, which affects the detection results of the MOT. In response to the shortage of noise and interference texture, a new non-contact image analysis method is developed. Firstly, Multi-scale Retinex (MSR) is proposed to pre-process the images for contrast enhancement; secondly, a fourth-order Gaussian derivative steerable filter is employed to enhance the structure of the texture; next, based on the probability density distribution function and the orientations of the enhanced images, the noise suppression function and the orientation-filtering function are designed to filter out the noise to highlight the texture. Finally, the Fourier Maximum Angle Analysis (FMAA) is used to filter out the noise further and obtain the clear orientations to achieve the measurement of velocity and discharge. The experimental results show that, compared with the widely used image velocimetry measurements, the accuracy of our method in the average velocity and flow discharge is significantly improved, and the real-time performance is excellent.

A Velocity Measurement Method Based on Charge Induction.

In this paper, based on the principle of charge induction, a new velocity measurement method is proposed. A moving target generates a low-frequency electric field, which can be induced with an electrode and detection frontend. Velocity measurements are achieved by placing two electrodes at a fixed distance to detect the characteristic times. Firstly, the electric field generated by the moving target is modeled, and the theoretical output of the detection frontend is obtained via a simulation of the target passing by a single electrode. Then, according to the theoretical output, the velocity measurement simulation results of double electrodes are given for various driving conditions, such as a single vehicle driving in a single lane, a single vehicle changing lanes, two vehicles driving close together, and a multiple-vehicle situation. Finally, the above driving conditions are experimentally verified in sunny weather, windy and rainy weather, and a night environment.

An Integrated Interferometric Fiber Optic Sensor Using a 638 nm Semiconductor Laser for Air-Water Surface Velocity Measurements.

An integrated interferometric fiber optic velocimetry sensor has been proposed and demonstrated at the central wavelength of 638 nm. The sensor is based on the principle of two laser-beams' interference. The light signal scattered from the particles or vapor is demodulated to measure the water surface velocity and water vapor velocity. Three velocity measurement experiments are carried out to measure the velocity, and the experimental data shows that the velocity increases linearly in the range of 4 mm·s-1 to 100 mm·s-1, with a slope of linear fitting curve of 0.99777 and the R-Square of 1.00000. The velocity calculated from frequency shift fits well with the reference velocity. The maximum average relative error in the three velocity measurements is less than 2.5%. In addition, the maximum speed of 4.398 m·s-1 is confirmed in the rotating disk calibration experiment, which expands the sensor's velocity measurement range. To solve the problem that it is difficult to directly measure the velocity of small-scale water surface flow velocity, especially from the aspect of the low velocity of air-water surface, the interferometric fiber optic sensor can be applied to the measurement of water surface velocity and wind velocity on the water surface.

Development of Measurement Method for Temperature and Velocity Field with Optical Fiber Sensor.

We have developed a new method for measuring temperature and velocity at a high spatial resolution (minimum 2.56 mm pitch along an optical fiber). The developed method uses the same principle as a hot wire anemometer, where the velocity perpendicular to an optical fiber is estimated as a function of the cooling curve of a gold-coated layer on the optical fiber Joule-heated intermittently. The developed optical fiber sensor demonstrated the ability to acquire a transient velocity profile in airflow experiments with high repeatability and accuracy. This paper describes optical fiber-based velocity measurement in the velocity range of approximately 0-7 m/s with an error of approximately 10% compared to a hot wire anemometer and a new method for simultaneous temperature and velocity measurements. Applicability to velocity distribution measurements and seconds transient velocity changes are also described.

A New Contactless Cross-Correlation Velocity Measurement System for Gas-Liquid Two-Phase Flow.

Based on the principle of Contactless Conductivity Detection (CCD), a new contactless cross-correlation velocity measurement system with a three-electrode construction is developed in this work and applied to the contactless velocity measurement of gas-liquid two-phase flow in small channels. To achieve a compact design and to reduce the influence of the slug/bubble deformation and the relative position change on the velocity measurement, an electrode of the upstream sensor is reused as an electrode of the downstream sensor. Meanwhile, a switching unit is introduced to ensure the independence and consistency of the upstream sensor and the downstream sensor. To further improve the synchronization of the upstream sensor and the downstream sensor, fast switching and time compensation are also introduced. Finally, with the obtained upstream and downstream conductance signals, the velocity measurement is achieved by the principle of cross-correlation velocity measurement. To test the measurement performance of the developed system, experiments are carried out on a prototype with a small channel of 2.5 mm. The experimental results show that the compact design (three-electrode construction) is successful, and its measurement performance is satisfactory. The velocity range for the bubble flow is 0.312-0.816 m/s, and the maximum relative error of the flow rate measurement is 4.54%. The velocity range for the slug flow is 0.161 m/s-1.250 m/s, and the maximum relative error of the flow rate measurement is 3.70%.

Acoustic Velocity Measurement for Enhancing Laser UltraSound Imaging Based on Time Domain Synthetic Aperture Focusing Technique.

A method to enhance laser ultrasound (LUS) image reconstruction with the time-domain synthetic aperture focusing technique (T-SAFT) is presented, in which the acoustic velocity is extracted in situ with curve fitting. The operational principle is provided with the help of a numerical simulation, and the confirmation is provided experimentally. In these experiments, an all-optic LUS system was developed by using lasers for both excitation and detection of ultrasound. The acoustic velocity of a specimen was extracted in situ by fitting a hyperbolic curve to its B-scan image. The needle-like objects embedded within a polydimethylsiloxane (PDMS) block and a chicken breast have been successfully reconstructed using the extracted in situ acoustic velocity. Experimental results suggest that knowing the acoustic velocity in the T-SAFT process is important not only in finding the depth location of the target object but also for producing a high resolution image. This study is expected to pave the wave to the development and usage of all-optic LUS for bio-medical imaging.

Data Processing Approaches to Measure Velocity of Electromagnetic Gun on Laser Screen in Complex Environment.

The exit velocity of the armature is an important indicator in measuring the launching performance of the electromagnetic gun. The non-contact photoelectric detection technology with the use of a laser screen was applied to the measurement of the armature velocity of the electromagnetic gun. By means of taking the signals that pass through the laser screen obtained by the velocity measurement system as the research object, we solved problems such as the harsh test environment of the launch armature velocity of the electromagnetic gun, the interferences on the armature signal passing through the laser screen unavoidably caused by various factors such as vibration, electromagnetic interference, shock wave, flare, smoke and fragments, and even the non-recognition of the signal passing through the laser screen in severe cases. A data-processing algorithm that combines the Ensemble Empirical Mode Decomposition (EEMD) with Correlation Algorithm (CA) was proposed, with the aim of processing the signals passing through the laser screen, while using the maximum slope point as the time passing through the laser screen so as to calculate the velocity of the armature passing the laser screen. This method can effectively reduce the influence of interference on the test results, and the test results from two sets of velocity measuring systems show that the velocity obtained by the proposed approach is highly consistent.

A New Adaptive GCC Method and Its Application to Slug Flow Velocity Measurement in Small Channels.

In this work, an adaptive generalized cross-correlation (AGCC) method is proposed that focuses on the problem of the conventional cross-correlation method not effectively realizing the time delay estimation of signals with strong periodicity. With the proposed method, the periodicity of signals is judged and the center frequencies of the strongly periodical components are determined through the spectral analysis of the input signals. Band-stop filters that are used to suppress the strongly periodical components are designed and the mutual power spectral density of the input signals that is processed by the band-stop filters is calculated. Then, the cross-correlation function that is processed is the inverse Fourier transform of the mutual power spectral density. Finally, the time delay is estimated by seeking the peak position of the processed cross-correlation function. Simulation experiments and practical velocity measurement experiments were carried out to verify the effectiveness of the proposed AGCC method. The experimental results showed that the new AGCC method could effectively realize the time delay estimation of signals with strong periodicity. In the simulation experiments, the new method could realize the effective time delay estimation of signals with strong periodicity when the energy ratio of the strongly periodical component to the aperiodic component was under 150. Meanwhile, the cross-correlation method and other generalized cross-correlation methods fail in time delay estimation when the energy ratio is higher than 30. In the practical experiments, the velocity measurement of slug flow with strong periodicity was implemented in small channels with inner diameters of 2.0 mm, 2.5 mm and 3.0 mm. With the proposed method, the relative errors of the velocity measurement were less than 4.50%.

Research on an LEO Constellation Multi-Aircraft Collaborative Navigation Algorithm Based on a Dual-Way Asynchronous Precision Communication-Time Service Measurement System (DWAPC-TSM).

In order to solve the collaborative navigation problems in challenging environments such as insufficient visible satellites, obstacle reflections and multipath errors, and in order to improve the accuracy, usability, and stability of collaborative navigation and positioning, we propose a dual-way asynchronous precision communication-timing-measurement system (DWAPC-TSM) LEO constellation multi-aircraft cooperative navigation and positioning algorithm which gives the principle, algorithm structure, and error analysis of the DWAPC-TSM system. In addition, we also analyze the effect of vehicle separation range on satellite observability. The DWAPC-TSM system can achieve high-precision ranging and time synchronization accuracy. With the help of this system, by adding relative ranging and speed measurement observations in an unscented Kalman filter (UKF), the multi-aircraft coordinated navigation and positioning of aircraft is finally realized. The simulation results show that, even without the aid of an altimeter, the multi-aircraft cooperative navigation and positioning algorithm based on the DWAPC-TSM system can achieve good navigation and positioning results, and with the aid of the altimeter, the cooperative navigation and positioning accuracy can be effectively improved. For the formation flight configurations of horizontal collinear and vertical collinear, the algorithm is universal, and in the case of vertical collinear, the navigation performance of the formation members tends to be consistent. Under different relative measurement accuracy, the algorithm can maintain good robustness; compared with some existing classical algorithms, it can significantly improve the navigation and positioning accuracy. A reference scheme for exploring the feasibility of a new cooperative navigation and positioning mode for LEO communication satellites is presented.

Two Wire Sensor for Measuring the Velocity of Non-Isothermal Flows.

Changes in the temperature of the medium significantly affect the static characteristics of hot-wire anemometry measuring wires, which causes errors in the results of flow velocity measurements. High temperatures of the medium make it necessary to additionally heat the sensor to even higher temperatures, which may lead to its damage due to wire burnout. The article proposes a solution to the problem of measuring the flow velocity in conditions of non-stationary temperatures with the use of the method of cross-correlation of signals from two-wire resistance thermometers. The main assumptions of the method and its experimental verification were presented.

Automatic Measurement of the Carotid Blood Flow for Wearable Sensors: A Pilot Study.

The assessment of the velocity of blood flowing in the carotid, in modern clinical practice, represents an important exam performed both in emergency situations and as part of scheduled screenings. It is typically performed by an expert sonographer who operates a complex and costly clinical echograph. Unfortunately, in developing countries, in rural areas, and even in crowded modern cities, the access to this exam can be limited by the lack of suitable personnel and ultrasound equipment. The recent availability of low-cost, handheld devices has contributed to solving part of the problem, but a wide access to the exam is still hampered by the lack of expert sonographers. In this work, an automated procedure is presented with the hope that, in the near future, it can be integrated into a low-cost, handheld instrument that is also suitable for self-measurement, for example, as can be done today with the finger oximeter. The operator should only place the probe on the neck, transversally with respect to the common tract of the carotid. The system, in real-time, automatically locates the vessel lumen, places the sample volume, and performs an angle-corrected velocity measurement of the common carotid artery peak velocity. In this study, the method was implemented for testing on the ULA-OP 256 scanner. Experiments on flow phantoms and volunteers show a performance in sample volume placement similar to that achieved by expert operators, and an accuracy and repeatability of 3.2% and 4.5%, respectively.

A Novel Defect Estimation Approach in Wind Turbine Blades Based on Phase Velocity Variation of Ultrasonic Guided Waves.

The reliability of the wind turbine blade (WTB) evaluation using a new criterion is presented in the work. Variation of the ultrasonic guided waves (UGW) phase velocity is proposed to be used as a new criterion for defect detection. Based on an intermediate value between the maximum and minimum values, the calculation of the phase velocity threshold is used for defect detection, location and sizing. The operation of the proposed technique is verified using simulation and experimental studies. The artificially milled defect having a diameter of 81 mm on the segment of WTB is used for verification of the proposed technique. After the application of the proposed evaluation technique for analysis of the simulated B-scan image, the coordinates of defect edges have been estimated with relative errors of 3.7% and 3%, respectively. The size of the defect was estimated with a relative error of 2.7%. In the case of an experimentally measured B-scan image, the coordinates of defect edges have been estimated with relative errors of 12.5% and 3.9%, respectively. The size of the defect was estimated with a relative error of 10%. The comparative results obtained by modelling and experiment show the suitability of the proposed new criterion to be used for the defect detection tasks solving.

Dual-Frequency Doppler LiDAR Based on External Optical Feedback Effect in a Laser.

A novel Dual-frequency Doppler LiDAR (DFDL) is presented where the dual-frequency light source is generated by using external optical feedback (EOF) effect in a laser diode (LD). By operating a LD at period-one (P1) state and choosing suitable LD related parameters, a dual-frequency light source can be achieved. Such a dual-frequency source has advantages of the minimum part-count scheme, low cost in implementation, and ease in optical alignment. Theory and system design are presented for the proposed DFDL for velocity measurement with high measurement resolution. The proposed design has a potential contribution to the Light Detection And Ranging (LiDAR) in practical engineering applications.

Photoelectric Sensor for Fast and Low-Priced Determination of Bi- and Triphasic Segmented Slug Flow Parameters.

Applying multiphase systems in microreactors leads to an intensification of heat and mass transport. Critical aspects of the well-studied segmented slug-flow, such as bubble generation and pump control, can be automated, provided a robust sensor for the reliable determination of velocity, phase lengths, and phase ratio(s) is available. In this work, a fast and low-priced sensor is presented, based on two optical transmission sensors detecting flow characteristics noninvasively together with a microcontroller. The resulting signal is mainly due to refraction of the bubble-specific geometries as shown by a simulation of light paths. The high performance of the processing procedure, utilizing the derivative of the signal, is demonstrated for a bi- and triphasic slug flow. The error of <5% is entirely reasonable for the purpose envisaged. The sensor presented is very fast, robust, and inexpensive, thus enhancing the attractiveness of parallelized capillary reactors for industrial applications.

Development of a Shock and Detonation Velocity Measurement System Using Chirped Fiber Bragg Gratings.

Dynamic measurements of shock and detonation velocities are performed using long chirped fiber Bragg gratings (CFBGs). Such thin probes, with a diameter of typically 125 µm or even 80 µm can be directly inserted into high-explosive (HE) samples or simply glued laterally. During the detonation, the width of the optical spectrum is continuously reduced by the propagation of the wave-front, which physically shortens the CFBG. The light power reflected back shows a ramp-down type signal, from which the wave-front position is obtained as a function of time, thus yielding a detonation velocity profile. A calibration procedure was developed, with the support of optical simulations, to cancel out the optical spectrum distortions from the different optical components and to determine the wavelength-position transfer function of the CFBG. The fitted slopes of the X-T diagram give steady detonation velocity values which are in very good agreement with the classical measurements obtained from discrete electrical shorting pins (ESP). The main parameters influencing the uncertainties on the steady detonation velocity value measured by CFBG are discussed. To conclude, different HE experimental configurations tested at CEA (Commissariat à l'Energie Atomique et aux Energies Alternatives) are presented: bare cylindrical sticks, wedges for shock-to-detonation transitions (SDT), spheres, a cast-cured stick around a CFBG, and a detonation wave-front profile configuration.

Research on Target Deviation Measurement of Projectile Based on Shadow Imaging Method in Laser Screen Velocity Measuring System.

In the laser screen velocity measuring (LSVM) system, there is a deviation in the consistency of the optoelectronic response between the start light screen and the stop light screen. When the projectile passes through the light screen, the projectile's over-target position, at which the timing pulse of the LSVM system is triggered, deviates from the actual position of the light screen (i.e., the target deviation). Therefore, it brings errors to the measurement of the projectile's velocity, which has become a bottleneck, affecting the construction of a higher precision optoelectronic velocity measuring system. To solve this problem, this paper proposes a method based on high-speed shadow imaging to measure the projectile's target deviation, ΔS, when the LSVM system triggers the timing pulse. The infrared pulse laser is collimated by the combination of the aspherical lens to form a parallel laser source that is used as the light source of the system. When the projectile passes through the light screen, the projectile's over-target signal is processed by the specially designed trigger circuit. It uses the rising and falling edges of this signal to trigger the camera and pulsed laser source, respectively, to ensure that the projectile's over-target image is adequately exposed. By capturing the images of the light screen of the LSVM system and the over-target projectile separately, this method of image edge detection was used to calculate the target deviation, and this value was used to correct the target distance of the LSVM to improve the accuracy of the measurement of the projectile's velocity.

Salinity Independent Flow Measurement of Vertical Upward Gas-Liquid Flows in a Small Pipe Using Conductance Method.

Flow measurement in gas-liquid two-phase flow is always a challenging work, because of the non-uniform phase distribution, severe slippage effect between phases, and different flow structures. Furthermore, the variation of salinity changes the water conductivity, which brings more difficulties to multiphase flow measurement. In this study, a methodology for flow measurement using the conductance method in gas-liquid two-phase flow with salinity change is proposed. The methodology includes the suitable conductivity detection method, the strategy of using combined sensors, and the measurement models of flow parameters. A suitable conductivity detection method that can guarantee that the sensor output is linearly proportional to the conductivity is proposed. This conductivity detection method can ensure that the sensors have a high and constant resolution in the conductivity variation caused by water holdup under the conditions of water conductivity change. Afterward, a combined sensor system consisting of a water holdup sensor, velocity sensor, and water conductivity sensor is designed and experimentally evaluated in gas-water two-phase flow in a 20 mm inner diameter pipe. Considering the non-uniform phase distribution, severe slippage effect between phases, different flow structures, and the variation of salinity, a new water holdup measurement model and flow velocity measurement models are established to achieve salinity independent water holdup measurement and flow velocity measurement for the first time.

A Flow Velocity Measurement Method Based on a PVDF Piezoelectric Sensor.

To measure the flow velocity of a fluid without affecting its motion state, a method was proposed based on a polyvinylidene fluoride (PVDF) piezoelectric film sensor. A self-made PVDF piezoelectric sensor placed parallel with the flow direction was used to measure the flow velocity. First, the piezoelectric characteristics of PVDF were obtained theoretically. Next, the relationship between flow velocity and sound pressure was verified numerically. Finally, the relationship between flow velocity and the electrical output of the PVDF piezoelectric film was obtained experimentally. In conclusion, the proposed method was shown to be reliable and effective.

A Novel Autonomous Celestial Integrated Navigation for Deep Space Exploration Based on Angle and Stellar Spectra Shift Velocity Measurement.

Traditional autonomous celestial navigation usually uses astronomical angle as measurement, which is a function of spacecraft's position and can't resolve the spacecraft's velocity directly. To solve this problem, velocity measurement by stellar spectra shift is proposed in this paper. The autonomous celestial integrated navigation method is derived by combining velocity measurement with angle measurement, which can ensure the long-term high accuracy, real-time and continuous navigation performance for deep space exploration (DSE) missions. The observability of the integrated navigation system is analyzed. Moreover, the design of doppler navigator and hardware in-the-loop simulation system are described. Finally, a simulation example is employed to demonstration the feasibility and effectiveness of the proposed navigation algorithm.