[The effect of propanidid in patients with an increased tendency to cerebral convulsions (author's transl)]. / Zur Wirkung von Propanidid bei Patienten mit erhöhter zerebraler Krampfbereitschaft

In view of the observation of tonic-clonic convulsions after the use of Propanidid in certan patients, a study was undertaken of the effects of this drug (7 mg/kg) on the EEG of 2 volunteers with a known history of epilepsy. Both subjects developed tonic-clonic convulsions and showed typical alterations of the EEG pattern even before the onset of hyperventilation. These EEG alterations were producible also during complete relaxation. The convulsions were easily stopped by the administration of short-acting barbiturates. Similar observations reported in the literature are briefly discussed. The conclusion is drawn that Propanidid should not be given to patients with a known history of epilepsy or any other convulsive disease.

Anaphylactic and anaphylactoid reactions to intravenous anesthetic agents.

A brief review of anaphylactic and anaphylactoid reactions to some i.v. anaesthetic agents is presented. Etiology, mechanisms, preventive aspects and treatment are discussed.

[The isolation syndrome]. / Sindrom izoliatsii.

In a previously healthy woman aged 36 years with 16% of the skin surface burned, an injection of sombrevin elicited basilar artery thrombosis which manifested in isolation syndrome (IS) with temporary left sight paresis and vertical ocular divergence. Pathological investigation revealed the infarct involving right brain pedicle and pontine paramedian regions.

[Dangerous complications of sombrevin anesthesia]. / Opasnye oslozhneniia sombrevinovogo narkoza.

The experience of using sombrevin anesthesia in 3644 cases and its 3 severe complications which resulted in the development of terminal states up to the clinical death (reanimation was successful) is analyzed. This anesthesia is shown to be necessary under conditions providing a possibility of immediate fulfillment of the complex of highly skilled reanimation measures, with early solution of problems of succession between the polyclinic link and the reanimation hospital. Special attention is called to strict observation of the principle of the preliminary (the day before operation) examination by an anesthesiologist of the patients who are to be subjected to planned short operative interventions, for the individual choice of the method of anesthesia and prevention of severe complications after narcosis.

[Clinico-physiologic characteristics of intravenous sombrevin anesthesia in treating inflammatory diseases of the maxillofacial area]. / Kliniko-fiziologicheskie osobennosti vnutrivennoi anestezii sombrevinom pri lechenii vospalitel'nykh zabolevanii cheliustno-litsevoi oblasti.

The authors analyze the clinical applications of intravenous propanidid anesthesia in outpatient oral surgery for maxillofacial inflammations. The quality of this type of anesthesia, its adequacy, side effects, and terms of restoration of the psychophysiologic function and speech are discussed.

[Resuscitation in acute allergic reactions to drugs]. / Reanimatsiia pri ostrykh allergicheskikh reaktsiiakh na lekarstvennye sredstva.

Under analysis were 40 cases of allergic reactions of the immediate type arising in 38 patients following the application of various pharmacological agents. Urticaria and Quincke's edema were observed in 21 cases and anaphylactic shock--in 19 cases. Rare cases of anaphylactic shock following injections of sombrevin, polyglucin and clinical observations of the recurring character of the course of allergic reactions are described.