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2.
Acta Orthop ; 82(5): 596-601, 2011 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-22112191

RESUMEN

BACKGROUND AND PURPOSE: Soft tissue necrobiosis and T-lymphocyte infiltration within the periprosthetic soft tissue have been linked to a suggested hypersensitivity reaction of the delayed-type following the metal-on-metal arthroplasty. While we observed both synovial necrobiosis and lymphocyte infiltrates in synovial tissues with failed metal-on-polyethylene prostheses, we hypothesized that both findings are unspecific for metal-on-metal bearing coupes. Thus, we wished to quantify the extent of necrobiosis and the amount of T-lymphocyte infiltration in aseptically loosened metal-on-polyethylene prostheses. MATERIALS AND METHODS: We analyzed 28 consecutive synovial biopsy specimens obtained at revision surgery of aseptically loosened metal-on-polyethylene prostheses (19 hips and 9 knees) and quantified both the extent of necrobiosis vertically and the density of CD3+, CD4+, and CD8+ lymphocytes within the joint capsular tissue. We excluded patients with inflammatory skeletal disease or with a history of metal hypersensitivity. RESULTS: We found necrobiosis in 23 of 28 cases and it was most often connected with the superficial portions of the synovium. Necrobiosis of deeper tissues was seen in 8 specimens and it was strongly associated with superficial necrobiosis. While CD3+ lymphocytes were detected in each biopsy, 4 cases with more than 300 CD3+ lymphocytes were identified in the group of 26 cases that presented with more than 100 CD3+ lymphocytes within one high-power field. 16 cases with more than 100 CD3+ lymphocytes also showed concomitant superficial necrobiosis of the synovium. In the inflammatory infiltration of periprosthetic synovium, CD8+ lymphocytes predominated over CD4+ cells. INTERPRETATION: Synovial necrobiosis and infiltration of T-lymphocytes are common findings in tissues around aseptically loosened metal-on-polyethylene arthroplasty in patients without a clinically suspected metal hypersensitivity reaction. Thus, neither necrobiosis nor infiltration of T-lymphocytes should be considered to be specific for failed metal-on-metal bearings or metal hypersensitivity reaction.


Asunto(s)
Artroplastia de Reemplazo de Cadera , Artroplastia de Reemplazo de Rodilla , Trastornos Necrobióticos , Linfocitos T , Anciano , Artroplastia de Reemplazo de Cadera/efectos adversos , Artroplastia de Reemplazo de Cadera/métodos , Artroplastia de Reemplazo de Rodilla/efectos adversos , Artroplastia de Reemplazo de Rodilla/métodos , Materiales Biocompatibles/efectos adversos , Prótesis de Cadera/efectos adversos , Humanos , Hipersensibilidad/etiología , Prótesis de la Rodilla/efectos adversos , Recuento de Linfocitos , Metales/efectos adversos , Persona de Mediana Edad , Trastornos Necrobióticos/inducido químicamente , Trastornos Necrobióticos/inmunología , Trastornos Necrobióticos/patología , Polietilenos/efectos adversos , Diseño de Prótesis , Falla de Prótesis , Reoperación , Membrana Sinovial/patología , Linfocitos T/inmunología , Linfocitos T/patología
3.
Am J Surg Pathol ; 21(5): 563-5, 1997 May.
Artículo en Inglés | MEDLINE | ID: mdl-9158681

RESUMEN

Biomaterial used in surgery is relatively inert and non-toxic; however, adverse reactions may follow implantation of such foreign material. We describe the first two cases of bone and joint destruction by necrobiotic palisading suture granulomas. The hypersensitivity reaction occurred years after shoulder repair using silk sutures. One patient received chemotherapy for a mistaken diagnosis of tuberculous arthritis. Although very rare, foreign material should be included in the differential diagnosis of necrotizing granulomas. A history of surgery and microscopic examination with polarized light should allow recognition of this entity.


Asunto(s)
Hipersensibilidad a las Drogas/etiología , Granuloma/inducido químicamente , Proteínas de Insectos/efectos adversos , Trastornos Necrobióticos/inducido químicamente , Articulación del Hombro/patología , Hombro/patología , Suturas/efectos adversos , Adulto , Hipersensibilidad a las Drogas/patología , Granuloma/patología , Humanos , Masculino , Trastornos Necrobióticos/patología , Complicaciones Posoperatorias , Hombro/cirugía , Seda
5.
Dermatology ; 198(4): 394-5, 1999.
Artículo en Inglés | MEDLINE | ID: mdl-10449941

RESUMEN

The authors describe an adverse localized cutaneous reaction caused by the injection of disodium clodronate, histologically presenting as a necrobiotic palisading granuloma. This lesion is considered as an immunological type of granuloma that can be caused by various chemical or physical stimuli. Disodium clodronate should be included among the medicaments that can trigger this infrequent type of tissue reaction.


Asunto(s)
Analgésicos Opioides/efectos adversos , Ácido Clodrónico/efectos adversos , Granuloma/inducido químicamente , Trastornos Necrobióticos/inducido químicamente , Anciano , Femenino , Granuloma/patología , Humanos , Inyecciones Intramusculares , Trastornos Necrobióticos/patología
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