RESUMO
The purpose of this study was to investigate the relationship between mortality salience, death anxiety, and two moderating variables: self-esteem and religiosity. A total of 174 undergraduate students from the Mindanao State University-Main Campus in the Philippines were selected via convenience sampling. Specifically, the study was carried out to determine if both self-esteem and religiosity moderate the relationship between mortality salience and death anxiety. The results revealed that mortality salience was positively correlated with death anxiety among undergraduate students. Moreover, self-esteem significantly moderated the relationship between mortality salience and death anxiety, with low self-esteem enhancing this relationship. However, religiosity was found to be a non-significant moderator of the link between mortality salience and death anxiety. Overall, the findings of this study have implications for understanding these relationships and offer recommendations for further research.
RESUMO
BACKGROUND: Pineal region tumours remain challenging neurosurgical pathologies. METHODS: Detailed anatomical knowledge of the posterior incisural space and its variations is critical. An opaque arachnoidal membrane seals the internal cerebral and basal veins, leading to thalamic, basal ganglia, mesencephalic/pontine infarctions if injured. Medium-size tumours can be removed en-bloc with all traction/manipulation applied on the tumour side, virtually without contact of ependymal surfaces of the pulvinars or third ventricle. Sacrifice of the cerebello-mesencephalic fissure vein may be required. CONCLUSIONS: The sitting position offers superior anatomical orientation and remains safe with experienced teams. Meticulous microsurgical techniques and detailed anatomical knowledge are likely to secure safe outcomes.
Assuntos
Veias Cerebrais , Glândula Pineal , Terceiro Ventrículo , Humanos , Glândula Pineal/cirurgia , Postura Sentada , TálamoRESUMO
In the fission yeast Schizosaccharomyces pombe (S.pombe), heterochromatin domains are established and maintained by protein complexes that contain numerous RNA binding domains among their components. The fission yeast HP1 protein Swi6 is one such component and contains an unstructured RNA-binding hinge, which is important for the integrity and silencing of heterochromatin. In this study, we have used an RNA aptamer that likely binds to the Swi6 hinge with high affinity, as a tool to perturb the natural interactions mediated by this domain. When the hinge is blocked by the aptamer RNA, Swi6 appears to become less restricted to the pericentromeres and is enriched at specific euchromatic loci. This suggests a role for the Swi6 hinge, along with the chromoshadow domain (previously shown) in controlling the spread of heterochromatin in S.pombe. The study also highlights the potential of using a synthetic aptamer RNA as a tool to perturb nucleic acid - protein interaction in vivo with the objective of understanding the functional relevance of such an interaction.