Detalhe da pesquisa
1.
On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase.
Nucleic Acids Res
; 51(13): 6622-6633, 2023 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-37246710
2.
DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation.
J Biol Chem
; 298(10): 102462, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36067881
3.
Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase.
Nucleic Acids Res
; 49(14): 8294-8308, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34289056
4.
Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.
Nucleic Acids Res
; 48(20): 11495-11509, 2020 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105482
5.
Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.
Nucleic Acids Res
; 47(21): 11355-11367, 2019 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31620784
6.
Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects.
Int J Mol Sci
; 21(2)2020 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31941101
7.
The R736H cancer mutation in DNMT3A modulates the properties of the FF-subunit interface.
Biochimie
; 208: 66-74, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-36528185
8.
Genome-wide deposition of 6-methyladenine in human DNA reduces the viability of HEK293 cells and directly influences gene expression.
Commun Biol
; 6(1): 138, 2023 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36732350
9.
Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences.
J Mol Biol
; 434(7): 167482, 2022 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35131259
10.
Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3.
Commun Biol
; 5(1): 192, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35236925
11.
Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.
Commun Biol
; 5(1): 92, 2022 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35075236
12.
Deep Enzymology Studies on DNA Methyltransferases Reveal Novel Connections between Flanking Sequences and Enzyme Activity.
J Mol Biol
; 433(19): 167186, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34375615
13.
DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation.
Nat Commun
; 11(1): 3723, 2020 07 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32709850
14.
Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.
Nat Commun
; 11(1): 3355, 2020 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32620778