Do enzyme inducers modify haloperidol decanoate rate of release?

1. Plasma levels were monitored for about 18 months during therapy with haloperidol decanoate. When steady-state was reached, patients treated without enzyme inducers showed in their plasma concentrations a stable plateau and a very low fluctuation. Furthermore, doses were correlated to plasma levels (r = 0.9). 2. Contrary, patients treated with both haloperidol decanoate and enzyme inducers seemed to present in their plasma concentration a very large fluctuation with C min (plasma concentrations measured just before the injection) significantly lower than those of the other group. Moreover their C min values were excluded from the linear regression curve calculated between plasma levels and doses in patients without enzyme inducers. 3. Our data suggest a shortening of the absorption half-time of haloperidol. In this case, it seems necessary to diminish the interval between injections than to give higher dosage in order to maintain plasma concentrations.

[Plasma and intra-erythrocytic concentrations of copper and zinc in uremic patients treated by periodic hemodialysis]. / Concentrations de cuivre et de zinc plasmatiques et intra-érythrocytaires chez les sujets urémiques traités par hémodialyse périodique.

In this report, the authors have studied the plasma and red blood cell concentrations of both zinc and copper in 90 uremic patients treated by intermittent hemodialysis. They found that plasmatic and erythrocytic levels of zinc together with the copper red blood cell concentrations determined before and after the hemodialysis are not significantly different from these recorded on normal subjects. However, the plasmatic copper concentrations are markedly increased, although no relevant correlation between the determined values and those measured in the dialysis bath can be drawn. Plasmatic copper levels fluctuations have been followed on 5 patients during an hemodialysis period ranging from 4 to 36 months, and did not reveal any relevant increase of copper levels. The etiology of the plasmatic copper concentration still be remain to be determined.