Detalhe da pesquisa
1.
SAMPL7 protein-ligand challenge: A community-wide evaluation of computational methods against fragment screening and pose-prediction.
J Comput Aided Mol Des
; 36(4): 291-311, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35426591
2.
Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
J Am Chem Soc
; 141(22): 8951-8968, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31060360
3.
Synthesis of the Core Framework of the Cornexistins by Intramolecular Nozaki-Hiyama-Kishi Coupling.
Molecules
; 24(14)2019 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31336669
4.
Realisation of small molecule libraries based on frameworks distantly related to natural products.
Org Biomol Chem
; 16(17): 3160-3167, 2018 05 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29645063
5.
Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.
Chemistry
; 23(60): 15227-15232, 2017 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28983993
6.
Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.
Bioorg Med Chem
; 23(11): 2629-35, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25600406
7.
Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists.
Angew Chem Int Ed Engl
; 54(46): 13538-44, 2015 Nov 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26358926
8.
Synthesis of spirocyclic 1,2-diamines by dearomatising intramolecular diamination of phenols.
Chem Commun (Camb)
; 59(5): 607-610, 2023 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36533578
9.
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science
; 382(6671): eabo7201, 2023 11 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37943932
10.
Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds.
ChemMedChem
; 17(7): e202100641, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35191598
11.
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source.
J Vis Exp
; (171)2021 05 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34125095
12.
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
Sci Adv
; 7(16)2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33853786
13.
Rapid optimisation of fragments and hits to lead compounds from screening of crude reaction mixtures.
Commun Chem
; 3(1): 122, 2020 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36703375
14.
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Chem Sci
; 11(39): 10792-10801, 2020 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34094333
15.
Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
bioRxiv
; 2020 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-33269349
16.
Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease.
Nat Commun
; 11(1): 5047, 2020 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33028810
17.
Translation of innovative chemistry into screening libraries: an exemplar partnership from the European Lead Factory.
Drug Discov Today
; 23(9): 1578-1583, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29753124
18.
Organocatalytic synthesis of highly substituted furfuryl alcohols and amines.
Angew Chem Int Ed Engl
; 51(48): 12128-31, 2012 Nov 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23097350