Laboratory markers of adaptation to Arctic conditions: scientific search and prospects of implementation.

The complex of climatic and geographical conditions of the Arctic determines the high intensity of the polysystem adaptive response of the organism, the duration of which is additionally influenced by individual genetic characteristics, social conditions, psychological and work loads. Taking into account the relevance of timely prevention and early diagnosis of stress-induced somatic pathology in EMERCOM employees working in unfavorable climatic and geographical zones, the authors evaluated the informative value of determining the level of steroid hormones and insulin as laboratory markers of adaptation to Arctic conditions. The expediency of developing objective criteria for the interpretation of the insulin/cortisol index and studying the informativeness of the 17ONprogesterone level as the earliest marker of adaptation to unfavorable climatic and geographical conditions of the Arctic is substantiated.

[The laboratory diagnosis of autoimmune thyroid diseases in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. / Laboratornaia diagnostika autoimmunnykh zabolevanii shchitovidnoi zhelezy u likvidatorov posledstvii avarii na Chernobyl'skoi AES.

Serum antibodies to thyroid tissue antigens were tested by enzyme immunoassay and the thyroid hormonal status was analyzed in 80 liquidators of the Chernobyl accident consequences. Antibodies to thyroglobulin in concentration of 160.7 +/- 10.5 IU/ml were detected in 11 (13.7%) subjects 11-12 years after the accident. Antibodies to thyroperoxidase were detected in this cohort: the reaction was positive in 2.5% cases and weakly positive in 5%. Groups of liquidators with changed thyroid functional activity in the T3-T4-TTH system were identified. Immunochemical screening for thyroid hormones and antibodies is an affective method for the diagnosis of autoimmune thyroid diseases in liquidators.