RESUMO
Yew leaves poisoning is a rare life-threatening intoxication, whose diagnosis can be difficult. Initial symptoms are nausea, vomiting, abdominal pain, dizziness, tachycardia, muscle weakness, confusion, beginning within 1 hr from ingestion and followed by bradycardia, ventricular arrhythmias, ventricular fibrillation, severe hypotension, and death. Taxine-derived alkaloids are responsible for the toxicity of the yew leaves, blocking sodium and calcium channels, and causing conduction abnormalities. Because of lack of a specific antidote and limited efficacy of common antiarrhythmic drugs, prompt diagnosis, detoxification measures, and immediate hemodynamic support (also with transvenous cardiac stimulation) are essential.
Assuntos
Arritmias Cardíacas/induzido quimicamente , Cephalotaxus/intoxicação , Eletrocardiografia/métodos , Parada Cardíaca/induzido quimicamente , Extratos Vegetais/intoxicação , Folhas de Planta/intoxicação , Agonistas alfa-Adrenérgicos/uso terapêutico , Adulto , Idoso , Amiodarona/uso terapêutico , Antiarrítmicos/uso terapêutico , Arritmias Cardíacas/terapia , Reanimação Cardiopulmonar , Carvão Vegetal/uso terapêutico , Feminino , Lavagem Gástrica , Parada Cardíaca/terapia , Humanos , Sulfato de Magnésio/uso terapêutico , Masculino , Pessoa de Meia-Idade , Norepinefrina/uso terapêutico , Marca-Passo Artificial , Bicarbonato de Sódio/uso terapêutico , Resultado do TratamentoRESUMO
In the context of SARS-CoV-2 pandemic, rapid and easy-to-perform diagnostic methods are essential to limit the spread of the virus and for the clinical management of COVID-19 patients. Although real-time polymerase chain reaction remains the "gold standard" to diagnose acute infections, this technique is expensive, requires trained personnel, well-equipped laboratory and is time-consuming. A prospective evaluation of the Abbott ID NOW COVID-19 point-of-care testing that uses isothermal nucleic acid amplification for the qualitative detection of SARS-CoV-2 RdRp gene was run in the Emergency Department during the third wave of COVID-19 pandemic. ID-NOW significantly simplified SARS-CoV-2 identification and COVID-19 patient triaging, being highly valuable in rapidly locating febrile patients in or out of COVID-19 areas, and can be considered as a first-line diagnostic test in the Emergency Room setting.